[1]罗 君,邵国良,姚红响,等.单纯胆道支架与支架联合125I粒子条植入治疗恶性梗阻性黄疸：一项回顾性对照研究[J].介入放射学杂志,2021,30(12):1256-1260.
　LUO Jun,SHAO Guoliang,YAO Hongxiang,et al.Simple biliary stenting versus biliary stenting combined with 125I seed strands implantation for the treatment of malignant obstructive jaundice： a retrospective controlled study[J].journal interventional radiology,2021,30(12):1256-1260.
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单纯胆道支架与支架联合125I粒子条植入治疗恶性梗阻性黄疸：一项回顾性对照研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
30
期数:
2021年12
页码:
1256-1260
栏目:
非血管介入
出版日期:
2021-12-25

文章信息/Info

Title:
Simple biliary stenting versus biliary stenting combined with 125I seed strands implantation for the treatment of malignant obstructive jaundice： a retrospective controlled study
作者:
罗 君;  邵国良;  姚红响;  郑家平;  曹 非;  钱超一
Author(s):
LUO Jun;  SHAO Guoliang;  YAO Hongxiang;  ZHENG Jiaping;  CAO Fei;  QIAN Chaoyi.
Department of Intervention， Affiliated Cancer Hospital of the University of Chinese Academy of Sciences（Zhejiang Provincial Cancer Hospital）； Institute of Cancer and Basic Medicine， Chinese Academy of Sciences； Hangzhou， Zhejiang Province 310022， China
关键词:
【关键词】 125I粒子; 近距离放射治疗;  恶性肿瘤;  梗阻性黄疸;  胆道支架
文献标志码:
A
摘要:
【摘要】 目的 评价胆道支架联合125I粒子条植入在恶性梗阻性黄疸（MOJ）患者中的安全性与疗效。方法 回顾性分析2015年3月至2020年9月收治的62例MOJ患者，其中27例接受胆道支架联合125I粒子条植入（观察组），35例仅接受单纯胆道支架植入（对照组）。分析两组患者的支架通畅率、不良反应发生率和生存期。结果 所有患者手术的技术均获成功，临床有效率观察组为96.3%，对照组为97.1%（P=0.228）。观察组术后Child-Pugh评分下降（1.63±1.11）分，显著优于对照组的（0.8±1.49）分（P=0.019）。观察组的中位支架通畅时间和中位总生存期（mOS）分别为41.3周和44.6周，显著优于对照组的28周和31周（P＜0.05）。术后并发症方面，两组差异无统计学意义。结论 支架联合碘125粒子条植入对MOJ的治疗安全、有效，值得进一步应用和研究。

参考文献/References:

［1］ Barkay O， Mosler P， Schmitt CM， et al. Effect of endoscopic stenting of malignant bile duct obstruction on quality of life［J］. J Clin Gastroenterol， 2013， 47： 526- 531.
［2］ Kurniawan J， Hasan I， Gani RA， et al. Mortality- related factors in patients with malignant obstructive jaundice［J］. Acta Med Indones， 2016， 48： 282- 288.
［3］ Pang Q， Zhou L， Hu XS， et al. Biliary stenting alone versus biliary stenting combined with 125I particles intracavitary irradiation for the treatment of advanced cholangiocarcinoma［J］. Sci Rep， 2019， 9： 11348.
［4］ Jiao D， Zhou X， Li Z， et al. A newly designed biliary brachytherapy drainage catheter for patients with malignant biliary obstruction： a pilot study［J］. J Cancer Res Ther， 2020， 16： 286- 291.
［5］ Wang Y， Lu J， Guo JH， et al. A novel tracheobronchial stent loaded with 125I seeds in patients with malignant airway obstruction compared to a conventional stent： a prospective randomized controlled study［J］. EBioMedicine， 2018， 33： 269- 275.
［6］ Chi Z， Chen L， Huang J， et al. A novel combination of percutaneous stenting with iodine- 125 seed implantation and chemotherapy for the treatment of pancreatic head cancer with obstructive jaundice［J］. Brachytherapy， 2021， 20： 218- 225.
［7］ 张 玥，王 涛，岳振东，等． TIPS联合125I粒子植入治疗肝癌门脉主干癌栓及合并症的效果［J］． 介入放射学杂志， 2020， 29：89- 95．
［8］ Chen Y， Wang XL， Yan ZP， et al. Damage to pig bile duct caused by intraluminal brachytherapy using a 125I ribbon［J］. Acta Radiol， 2013， 54： 272- 277.
［9］ Pan T， Li MA， Mu LW， et al. Stent placement with iodine- 125 seeds strand effectively extends the duration of stent patency and survival in patients with unresectable malignant obstructive jaundice［J］. Scand J Gastroenterol， 2020， 55： 123- 128.
［10］ Cao J， Wang Z， Cai H， et al. Effect of PTCD- based biliary stent placement combined with 125I particle intracavitary irradiation in treating pancreatic head cancer［J］. J BUON， 2020， 25： 1056- 1062.
［11］ Chen W， Fang XM， Wang X， et al. Preliminary clinical application of integrated 125I seeds stents in the therapy of malignant lower biliary tract obstruction［J］. J Xray Sci Technol， 2018， 26： 865- 875.
［12］ Zhang JX， Wang B， Liu S， et al. Predictors of recurrent biliary obstruction following percutaneous uncovered metal stent insertion in patients with distal malignant biliary obstruction： an analysis using a competing risk model［J］. Cardiovasc Intervent Radiol， 2019， 42： 276- 282.
［13］ 徐红豆，周卫忠，刘 圣，等． 经皮胆道支架联合125I粒子条腔内植入治疗恶性梗阻性黄疸的疗效分析［J］． 介入放射学杂志， 2020， 29：83- 88．
［14］ Ma J， Luo J， Gu J， et al. Malignant obstructive jaundice treated with intraluminal placement of Iodine- 125 seed strands and metal stents： an analysis of long- term outcomes and prognostic features［J］. Brachytherapy， 2018， 17： 689- 695.
［15］ Li S， He X， Dang L， et al. Efficacy of 125I versus non- 125I combined with transcatheter arterial chemoembolization for the treatment of unresectable hepatocellular carcinoma with obstructive jaundice［J］. Dig Dis Sci， 2018， 63： 321- 328.
［16］ Zhu HD， Guo JH， Huang M， et al. Irradiation stents vs. conven-tional metal stents for unresectable malignant biliary obstruction： a multicenter trial［J］. J Hepatol， 2018， 68： 970- 977.

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备注/Memo

备注/Memo:
（收稿日期：2021- 02- 26）
（本文编辑：俞瑞纲）
更新日期/Last Update: 2021-12-21