[1]娄 成,钱建新,顾小强,等.125I粒子植入治疗盆腔及后腹膜肿瘤23例分析[J].介入放射学杂志,2016,(07):631-634.
 LOU Cheng,QIAN Jian-xin,GU Xiao-qiang,et al.125I seed implantation for the treatment of pelvic and retroperitoneal malignant tumors: clinical analysis of 23 patients [J].journal interventional radiology,2016,(07):631-634.
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125I粒子植入治疗盆腔及后腹膜肿瘤23例分析 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2016年07期
页码:
631-634
栏目:
临床研究
出版日期:
2016-07-25

文章信息/Info

Title:
125I seed implantation for the treatment of pelvic and retroperitoneal malignant tumors: clinical analysis of 23 patients

作者:
 娄 成 钱建新 顾小强 武 清
Author(s):
LOU Cheng QIAN Jian-xin GU Xiao-qiang WU Qin
Department of Oncology, Affiliated Changzheng Hospital, Second Military Medical School, Shanghai 200070, China
关键词:
【关键词】 125I粒子 后腹盆及腔膜恶性肿瘤 CT引导下 临床疗效
文献标志码:
A
摘要:
【摘要】 目的 评价CT引导下放射性125I粒子植入治疗盆腔及后腹膜恶性肿瘤的临床疗效。方法 23例盆腔及后腹膜恶性肿瘤患者,在CT引导下行放射性125I粒子植入。粒子植入前1周行腹部或盆腔螺旋CT扫描,将图像传送到计算机三维肿瘤治疗计划系统;勾画靶区轮廓(同时勾画肿瘤周围危险器官,如膀胱、肠管、大血管等);靶区及相关轮廓三维重建;确定肿瘤靶区放射剂量、粒子数量和粒子空间排列。术后随访均设定4个月,以观察局部治疗效果、有无消化道或泌尿系等不良反应、疼痛变化情况、局部肿瘤缓解情况。结果 本组23例中有16例患者术前有骶尾部或腰背部疼痛,术后5~14 d疼痛缓解,缓解率为69.6%,局部疼痛缓解近期疗效较显著。肿瘤局部控制2个月时有效率(CR+PR)为47.8%(11/23);4个月时有效率为43.5%(10/23)。患者术后随访未见腹痛、肠瘘、出血、尿痛等不良反应,也未见放射性肠炎、骨髓抑制等并发症。结论 初步研究表明CT引导下经皮穿刺植入125 I粒子近距离内照射治疗盆腔及后腹膜肿瘤安全、局部疗效明显等优势。对于无法手术、术后复发及单纯化、放疗效果差的盆腔及后腹膜恶性肿瘤是一种有效的补救治疗措施,并有效改善患者生存质量、提高肿瘤局部控制率。

参考文献/References:

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备注/Memo

备注/Memo:
(收稿日期:2016-04-03)


(本文编辑:俞瑞纲)
更新日期/Last Update: 2016-07-18