[1]王伟昱,秦汉林,朱先海,等.不同活度125I粒子植入抑制兔VX2肝癌机制研究[J].介入放射学杂志,2015,(05):426-429.
 WANG Wei yu,QIN Han lin,ZHU Xian hai,et al.The inhibition effect of interstitial brachytherapy with different radioactivity 125I seeds on liver VX2 tumor in experimental rabbits: study of its mechanism[J].journal interventional radiology,2015,(05):426-429.
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不同活度125I粒子植入抑制兔VX2肝癌机制研究 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年05期
页码:
426-429
栏目:
实验研究
出版日期:
2015-05-25

文章信息/Info

Title:
The inhibition effect of interstitial brachytherapy with different radioactivity 125I seeds on liver VX2 tumor in experimental rabbits: study of its mechanism
作者:
王伟昱 秦汉林 朱先海 周 磊 武乐斌
Author(s):
WANG Wei yu QIN Han lin ZHU Xian hai ZHOU Lei WU Lei bin
Department of Interventional Radiology, Anhui Provincial Tumor Hospital, Hefei, Anhui Province 230001, China
关键词:
【关键词】 125I粒子 VX2肝癌模型 抑癌机制凋亡
文献标志码:
A
摘要:
【摘要】 目的 探讨125I粒子组织间植入诱导肝癌细胞凋亡的机制。比较不同活度125I粒子组织间植入诱导肿瘤细胞凋亡、抑制肿瘤细胞增殖的作用强度。方法 将24只兔VX2肝癌模型随机分为3组,分别植入不同初始活度的125I粒子:0 mCi组(对照组,n=8)、0.7 mCi组(n=8)及1.0 mCi组(n=8)。5周后处死实验兔,取出肿瘤病灶,检测125I粒子对肿瘤细胞凋亡、肿瘤生长相关因子表达的影响及caspase 3 活性改变。结果 不同初始活度125I粒子均可使肿瘤细胞凋亡率上升, Bcl 2、VEGF表达下调,Bax表达上调,1.0 mCi 125I粒子组作用均更加明显(P<0.05)。不同初始活度125I粒子可增加肿瘤组织中caspase 3活性,两治疗组间差异无明显统计学意义(P>0.05)。结论 125I粒子植入后不仅通过诱导肿瘤细胞凋亡抑制肿瘤生长、增殖,还影响凋亡相关基因及编码蛋白表达,抑制肿瘤细胞新生血管生成。

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备注/Memo

备注/Memo:
(收稿日期:2014-11-03)
(本文编辑:边 佶)
更新日期/Last Update: 2015-05-19