[1]胡曙东,谌业荣,刘 玉,等.能谱CT早期评价125I粒子植入治疗胰腺癌效果实验研究[J].介入放射学杂志,2015,(12):1086-1089.
 HU Shu-dong,CHEN Ye-rong,LIU Yu,et al.Application of spectral CT imaging in making early evaluation of the effect of 125I particle interstitial brachytherapy for pancreatic carcinoma: an experimental study[J].journal interventional radiology,2015,(12):1086-1089.
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能谱CT早期评价125I粒子植入治疗胰腺癌效果实验研究 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年12期
页码:
1086-1089
栏目:
实验研究
出版日期:
2015-12-25

文章信息/Info

Title:
Application of spectral CT imaging in making early evaluation of the effect of 125I particle interstitial brachytherapy for pancreatic carcinoma: an experimental study
作者:
胡曙东 谌业荣 刘 玉 宋 琦 林晓珠 王忠敏 陈克敏
Author(s):
HU Shu-dong CHEN Ye-rong LIU Yu SONG Qi LIN Xiao-zhu WANG Zhong-min CHEN Ke-min
Department of Radiology, Affiliated Renmin Hospital of Jiangsu University, Zhenjiang, Jiangsu Province 212002, China
关键词:
【关键词】 125I粒子 短距离放疗 计算机体层摄影 能谱成像 胰腺癌 微血管密度
文献标志码:
A
摘要:
【摘要】 目的 探讨能谱CT成像早期评价125I粒子组织间植入治疗胰腺癌效果的应用价值。方法 人原位胰腺癌BxPC-3细胞株接种于16只BABL/c裸鼠四肢偏背侧皮下,成瘤1~1.5 cm;分别植入125I粒子(实验组,n=8)和空载粒子(对照组,n=8),2周后行能谱CT平扫及多期相(10 s、25 s、60 s)增强扫描,获取多期相系列图像。测量瘤体对比噪声比(CNR)和碘浓度(IC),得出瘤体标准化碘浓度(nIC)。瘤体免疫组化染色后,分析瘤体组织内微血管密度(MVD),nIC与MVD相关性。结果 实验组各期相(10 s、25 s、60 s)瘤体nIC值均低于对照组,差异有统计学意义(P<0.05);实验组MVD计数低于对照组,差异有显著统计学意义(t=5.957,P<0.01);各期相nIC与MVD均存在正线性相关(分别为r=0.63,P<0.000 1;r=0.51,P=0.002;r=0.48,P=0.001 7)。结论 能谱CT是监测125I粒子组织间植入治疗胰腺癌效果的有效方法。

参考文献/References:

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备注/Memo

备注/Memo:
(收稿日期:2015-05-26)
(本文编辑:边 佶)
更新日期/Last Update: 2015-12-24