[1]隋爱霞,于慧敏,张宏涛,等.治疗计划系统模拟125I粒子周边与中心分布剂量对比研究 [J].介入放射学杂志,2015,(05):422-425.
 SUI Ai xia,YU Hui min,ZHANG Hong tao,et al.Treatment planning system simulation of central and peripheral dose distribution of 125I seeds: a comparison study[J].journal interventional radiology,2015,(05):422-425.
点击复制

治疗计划系统模拟125I粒子周边与中心分布剂量对比研究 ()

PDF下载中关闭

分享到:

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年05期
页码:
422-425
栏目:
实验研究
出版日期:
2015-05-25

文章信息/Info

Title:
Treatment planning system simulation of central and peripheral dose distribution of 125I seeds: a comparison study
作者:
隋爱霞 于慧敏 张宏涛 吴 娟 任菊娜 高 贞 王 娟
Author(s):
SUI Ai xia' target="_blank" rel="external">"serif"; LINE-HEIGHT: 200%">SUI Ai xia YU Hui min ZHANG Hong tao WU Juan REN Ju na GAO Zhen WANG Juan
Department of Oncology, Hebei Provincial People’s Hospital, Shijiazhuang, Hebei Province 050051, China
关键词:
【关键词】  125I 计算机治疗计划系统 剂量 近距离放射治疗
文献标志码:
A
摘要:
【摘要】 目的 探讨同活度、同数量125I粒子周边分布与中心分布的剂量学差异。方法 采用计算机三维放射治疗计划系统(3D TPS)勾画出2、2.5、3、3.5、4、4.5、5 cm等7种边长的正方体,模拟不同大小肿瘤,分别载入0.5 mCi 125I粒子,处方剂量145 Gy,粒子周边分布(周边组),得出剂量体积直方图(DVH)及90%靶体积吸收剂量(D90)、90%处方剂量覆盖的体积占靶体积百分比(V90)、最高剂量点、平均剂量等参数;同样方法将以上各肿瘤中载入粒子作中心分布(中心组),得出上述参数。结果 周边组和中心组D90均数分别为(147.29±0.58)Gy和(106.08±9.40)Gy,差异有统计学意义(t=-4.292,P=0.005);V90均数分别为(95.46±0.44)%和(9.07±4.19)%,差异有统计学意义(t=-3.831,P=0.009);最高剂量均数分别为(1 224.65±12.7)Gy和(1 532.48±48.54)Gy,差异有统计学意义(t=6.823,P=0.000);平均剂量均数分别为(192.14±2.89)Gy和(179.81±5.40)Gy,差异有统计学意义(t=-2.847,P=0.029)。结论 125I粒子不同分布模式直接影响剂量分布,粒子数目和活度相同时周边布源有较好的剂量分布。

参考文献/References:

[1] Lee PC, Parks EK, Moran BJ. An innovative dosimetric model for formulating a semi analytical solution for the activity volume relationship in prostate implants[J]. Med Dosim, 2003, 28: 243 253.
[2] 胡逸民. 肿瘤放射物理学[M]. 北京: 原子能出版社, 1999: 614.
[3] Blasko JC, Grimm PD, Ragde H. Brachytherapy and organ preservation in the management of carcinoma of the prostate[J]. Semin Radiat Oncol, 1993, 3: 240 249.
[4] Blasko JC, Ragde H, Grimm PD. Transperineal ultrasound guided implantation of the prostate: morbidity and complications[J]. Scand J Urol Nephrol Suppl, 1991, 137: 113 118.
[5] Blasko JC, Wallner K, Grimm PD, et al. Prostate specific antigen based disease control following ultrasound guided 125iodine implantation for stage T1/T2 prostatic carcinoma[J]. J Urol, 1995, 154: 1096 1099.
[6] Stock RG, Stone NN, Wesson MF, et al. A modified technique allowing interactive ultrasound guided three dimensional trans perineal prostate implantation[J]. Int J Radiat Oncol Biol Phys, 1995, 32: 219 225.
[7] 唐富龙, 任菊娜, 吴 娟, 等. 125I 放射性粒子单平面布源剂量学研究[J]. 介入放射学杂志, 2014, 23: 619 622.
[8] Stock RG, Stone NN, Cesaretti JA, et al. Biologically effective dose values for prostate brachytherapy: effects on PSA failure and posttreatment biopsy results[J]. Int J Radiat Oncol Biol Phys, 2006, 64: 527 533.
[9] 王 娟, 孙美玲, 张宏涛, 等. 外放疗后复发颈部淋巴结转移癌17例125I粒子植入治疗的初步疗效[J]. 介入放射学杂志, 2014, 23: 784 787.
[10] Ashamalla H, Rafla S, Zaki B, et al. Radioactive Gold grain implants in recurrent and locally advanced head and neck cancers[J]. Brachytherapy, 2002, 1: 161 166.
[11] Gejerman G, Mullokandov E, Saini AJ, et al. The effects of edema on urethral dose following palladium 103 prostate brachy therapy[J]. Med Dosim, 2002, 27: 221 225.
[12] Lin L, Wang J, Jiang Y, et al. Interstitial 125I seed implantation for cervical lymph node recurrence after multimodal treatment of thoracic esophageal squamous cell carcinoma[J]. 2014, [Epub ahead of print].
[13] Gao F, Li C, Gu Y, et al. CT guided 125I brachytherapy for mediastinal metastatic lymph nodes recurrence from esophageal carcinoma: effectiveness and safety in 16 patients[J]. Eur J Radiol, 2013, 82: e70 e75.
[14] 吕 进, 曹秀峰. 碘 125粒子植入治疗肝细胞癌的剂量学[J]. 世界华人消化杂志, 2008, 16: 3295 3298.
[15] Xu KC, Niu LZ, Hu YZ, et al. A pilot study on combination of cryosurgery and 125iodine seed implantation for treatment of locally advanced pancreatic cancer[J]. World J Gastroenterol, 2008, 14: 1603 1611.
[16] Zhang L, Fan WJ, Huang JH, et al. CT guided 125I seeds implantation in treatment of local recurrent rectal cancer after surgery resection: analysis of 21 cases[J]. Zhonghua Yi Xue Za Zhi, 2008, 88: 1335 1338.
[17] 王俊杰, 田素青, 李金娜, 等. 放射性125I粒子平面永久插植布源剂量分布研究[J]. 中国微创外科杂志, 2005, 5: 1061 1062.
[18]王 娟, 张宏涛, 赵文清, 等. 125I粒子平面插植剂量学研究[J]. 中华实验外科杂志, 2010, 27: 201 203.
[19]杨之光, 刘兆玉, 畅智慧. CT引导下125I粒子永久性植入治疗肝内胆管细胞癌的临床疗效观察[J]. 中国临床医学影像杂志, 2010, 21: 440 442.
[20] Wang ZM, Liu Y, Liu FJ, et al. Clinical efficacy of CT guided iodine 125 seed implantation therapy in patients with advanced pancreatic cancer[J]. Eur Radiol, 2010, 20: 1786 1791.

相似文献/References:

[1]李任飞,王月东,闫 龑,等.125I粒子植入治疗非小细胞肺癌近期疗效评估[J].介入放射学杂志,2014,(01):65.
 LI Ren? fei,WANG Yue? dong,YAN Yan,et al. Implantation of 125I seeds for the treatment of non?蛳 small cell lung cancer: evaluation of short?蛳 term effect[J].journal interventional radiology,2014,(05):65.

备注/Memo

备注/Memo:
(收稿日期:2014-10-29)
(本文编辑:边 佶)
更新日期/Last Update: 2015-05-19