[1]胡曙东,谌业荣,刘 玉,等.能谱CT早期评价125I粒子植入治疗胰腺癌效果实验研究[J].介入放射学杂志,2015,(12):1086-1089.
　HU Shu-dong,CHEN Ye-rong,LIU Yu,et al.Application of spectral CT imaging in making early evaluation of the effect of 125I particle interstitial brachytherapy for pancreatic carcinoma： an experimental study[J].journal interventional radiology,2015,(12):1086-1089.
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能谱CT早期评价125I粒子植入治疗胰腺癌效果实验研究 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年12期
页码:
1086-1089
栏目:
实验研究
出版日期:
2015-12-25

文章信息/Info

Title:
Application of spectral CT imaging in making early evaluation of the effect of 125I particle interstitial brachytherapy for pancreatic carcinoma： an experimental study
作者:
胡曙东;  谌业荣;  刘 玉;  宋 琦;  林晓珠;  王忠敏;  陈克敏
Author(s):
HU Shu-dong;  CHEN Ye-rong;  LIU Yu;  SONG Qi;  LIN Xiao-zhu;  WANG Zhong-min;  CHEN Ke-min
Department of Radiology， Affiliated Renmin Hospital of Jiangsu University， Zhenjiang， Jiangsu Province 212002， China
关键词:
【关键词】 125I粒子;  短距离放疗;  计算机体层摄影;  能谱成像;  胰腺癌;  微血管密度
文献标志码:
A
摘要:
【摘要】 目的 探讨能谱CT成像早期评价125I粒子组织间植入治疗胰腺癌效果的应用价值。方法 人原位胰腺癌BxPC-3细胞株接种于16只BABL/c裸鼠四肢偏背侧皮下，成瘤1～1.5 cm；分别植入125I粒子（实验组，n=8）和空载粒子（对照组，n=8），2周后行能谱CT平扫及多期相（10 s、25 s、60 s）增强扫描，获取多期相系列图像。测量瘤体对比噪声比（CNR）和碘浓度（IC），得出瘤体标准化碘浓度（nIC）。瘤体免疫组化染色后，分析瘤体组织内微血管密度（MVD），nIC与MVD相关性。结果 实验组各期相（10 s、25 s、60 s）瘤体nIC值均低于对照组，差异有统计学意义（P＜0.05）；实验组MVD计数低于对照组，差异有显著统计学意义（t=5.957，P＜0.01）；各期相nIC与MVD均存在正线性相关（分别为r=0.63，P＜0.000 1；r=0.51，P=0.002；r=0.48，P=0.001 7）。结论 能谱CT是监测125I粒子组织间植入治疗胰腺癌效果的有效方法。

参考文献/References:

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备注/Memo

备注/Memo:
（收稿日期：２０１5-０5-26）
（本文编辑：边 佶）
更新日期/Last Update: 2015-12-24