[1]陈少伯,姜铁民,梁国庆,等.梗死相关动脉粥样斑块的虚拟组织学特点与妊娠相关血浆 蛋白A的相关性研究[J].介入放射学杂志,2011,(01):14.
 CHEN Shao-bo,JIANG Tie-min,LIANG Guo-qing,et al.Characteristics of virtual histology-intravascular unltrasound of infarction-related artery atheromatous plaque and pregnancy-associated plasma protein A level: a correlation study[J].journal interventional radiology,2011,(01):14.
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梗死相关动脉粥样斑块的虚拟组织学特点与妊娠相关血浆 蛋白A的相关性研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2011年01期
页码:
14
栏目:
心脏介入
出版日期:
2011-01-15

文章信息/Info

Title:
Characteristics of virtual histology-intravascular unltrasound of infarction-related artery atheromatous plaque and pregnancy-associated plasma protein A level: a correlation study
作者:
陈少伯 姜铁民 梁国庆 赵季红 李玉明
300162  天津医科大学研究生院;武警医学院附属医院心内科
Author(s):
CHEN Shao-bo JIANG Tie-min LIANG Guo-qing ZHAO Ji-hong LI YU-ming.

Department of Cardiology, Tianjin Medical University, Tianjin 300162, China

关键词:
心肌梗死 血管内超声 虚拟组织学 妊娠相关血浆蛋白A 相关
分类号:
文献标志码:
摘要:
目的   对比分析急性心肌梗死相关动脉粥样斑块和稳定性心绞痛症状相关病变的虚拟组织学特点,研究虚拟组织学特点和妊娠相关血浆蛋白A的关系,探讨急性心肌梗死发病的炎症机制。方法   2008年1月至2009年12月入住武警医学院附属医院的急性ST抬高性心肌梗死并行直接介入治疗患者70例,随机选取同期介入治疗的稳定性心绞痛患者70例为对照。完成冠状动脉造影之后,导入ZEEK抽吸导管至症状相关病变,抽取冠状动脉血,集中用酶联免疫法测定妊娠相关血浆蛋白A水平,然后按标准方法对症状相关动脉行血管内超声检查,保存普通灰阶图像和虚拟组织学超声数据。分析斑块的虚拟组织学特点及与妊娠相关血浆蛋白A的相关性。结果   两组患者年龄,性别,合并高血压、吸烟、糖尿病、高脂血症等临床资料差异无统计学意义(P > 0.05),对照组和急性心肌梗死组虚拟组织学血管内超声特点不同,急性心肌梗死组纤维脂质成份和坏死组织明显增多,钙化成份少。对照组和急性心肌梗死组的坏死组织/钙化组织面积比值分别为(3.62 ± 1.46)和(7.18 ± 2.53),两组间差异有统计学意义(P < 0.01)。急性心肌梗死组妊娠相关血浆蛋白A显著高于对照组(P < 0.01),且斑块的虚拟组织学参数与妊娠相关血浆蛋白A有相关性(P < 0.05或P < 0.01)。结论   急性心肌梗死相关动脉粥样斑块的虚拟组织学特点为坏死成份多,坏死/钙化面积比值大,与妊娠相关血浆蛋白A有很好相关性。

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:20100713
本课题为学院科研基金面上项目
更新日期/Last Update: 2011-01-15