[1]杨康健,赵思源,赵斌羽,等.兔肝癌改良接种模型的生长特性研究[J].介入放射学杂志,2010,(03):211.
　YANG Kangjian,ZHAO Siyuan,ZHAO Binyu,et al.The growing features of rabbit VX２hepatic carcinoma model prepared with modified inoculation method[J].journal interventional radiology,2010,(03):211.
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兔肝癌改良接种模型的生长特性研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2010年03期
页码:
211
栏目:
实验研究
出版日期:
2010-03-15

文章信息/Info

Title:
The growing features of rabbit VX２hepatic carcinoma model prepared with modified inoculation method
作者:
杨康健; 赵思源; 赵斌羽; 等
７１００３８西安第四军医大学唐都医院介入放射科
Author(s):
YANG Kang－jian; ZHAO Si－yuan; ZHAO Bin－yu; CAO Wei; LI Chao; YANG Qing－feng; WANG Zhi－min; ZHANG Hong－xin．
Tangdu Hospital，Fourth Military Medical University of Chinese PLA，Xi ’an，Shaanxi Province７１００３８，China
关键词:
兔VX２; 肝癌; 移植方式; 生长特性
分类号:
R７３５.７
文献标志码:
B
摘要:
目的通过改良接种方式建立兔肝癌模型，分析并观察该肿瘤的生长特性。方法经肝包膜植入瘤组织块（约１０ ６ ～１０ ８ 个瘤细胞）接种于２０只兔的肝左叶，建立兔肝癌模型。观察：①肿瘤在实验兔中生长７、１０、１４、１７和２１d时的体积（B超测），并计算肿瘤生长率。②大体及光镜下观察瘤组织形态特征。结果瘤体呈指数性生长，在接种１７d后生长迅速。组织病理表明该瘤在肝组织中浸润式生长，肿瘤体积增长快于直径增长，其性状与VX２鳞状细胞癌特征相似。结论瘤块种植是建立兔肝癌模型的首选方式，该模型是肝癌的基础及临床的理想动物模型。

参考文献/References:

［１］严惠芳，傅文君，任文龙．可移植性动物肿瘤株的冻存和复苏［J］．医药工业，１９８６，１７：２８－２９．
［２］Prat F，Centarti M，Sibille A，et al．Extracorporeal high－intensity focused ultrasound for VX２liver tumors in the rabbit［J］．Hepatology，１９９５，２１：８３２－８３６．
［３］Swistel AJ ，Bading JR，Raaf JH．Intraarterial versus intravenous Adriamycin in the rabbit VX２tumor system［J］．Cancer，１９８４，５３：１３９７－１４０４．
［４］Matsumua T，Moriyau F，Kono Y，et al．Contrast－enhancedpower Doppler imaging of the liver－preliminary animal study［J］．Nippon Rinsho，１９９８，５６：９８５－９８９．
［５］Leander T，Harada T，Yuri Y，et al．CT and MR imaging of the liver using liver－specific contrast media．A comparative study in a tumor model［J］．Acta Radiol，１９９６，３７：２４２－２４９．
［６］Kigure T，Harada T，Yuri Y，et al．Ultrasound－guided microwave thermotherapy on a VX２carcinoma implanted in rabbit kidney［J］．Ultrasound Med Biol，１９９５，２１：６４９－６５５．
［７］Okada M，Kudo S，Miyazaki O，et al．Antitumoral efficacy and pharmacokinetic properties of pirarubicin upon hepatic intra－arterial injection in the rabbit VX２tumor model［J］．Br J Cancer，１９９５，７１：５１８－５２４．
［８］曹玮，万毅，张洪新，等．脉冲式温热灌注对肿瘤血管渗透性的影响［J］．介入放射学杂志，２００８，１７：２６６－２６８．
［９］李广琪，陈毓秀，康军，等．兔肝VX２移植癌改良模型的建立［J］．武警医学院学报，２００７，１６：３６９－３７２．
［１０］曹玮，彭建明，王执民，等．６０℃碘油栓塞对兔肝VX２肿瘤血供的影响［J］．实用放射学杂志，２００８，２４：８３７－８３９．
［１１］曹玮，吴发伟，刘毅勇，等．高强度聚焦超声对中晚期肝癌患者机体免疫细胞及其活性的影响［J］．介入放射学杂志，２００９，１８：３０８－３１０．

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备注/Memo

备注/Memo:
收稿日期：２０１０－０２－２５
更新日期/Last Update: 2010-03-15