[1]史震山,陈自谦,杨熙章,等.原发性大肝癌患者TACE后S-腺苷蛋氨酸的护肝作用[J].介入放射学杂志,2008,(11):790.
 SHI Zhenshan,CHEN Ziqian,YANG Xizhang,et al.The clinical study on the liver-protection of S-adenosy-methionine in large hepatocellular carcinoma patients after TACE[J].journal interventional radiology,2008,(11):790.
点击复制

原发性大肝癌患者TACE后S-腺苷蛋氨酸的护肝作用()

PDF下载中关闭

分享到:

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2008年11期
页码:
790
栏目:
肿瘤介入
出版日期:
2008-11-15

文章信息/Info

Title:
The clinical study on the liver-protection of S-adenosy-methionine in large hepatocellular carcinoma patients after TACE
作者:
史震山陈自谦杨熙章
350025福州南京军区福州总医院影像中心介入病房(史震山、陈自谦、杨熙章、张鸿文、董其龙、杨永岩、雷娟);福建医科大学附属协和医院药学部(庄茜)
Author(s):
SHI Zhen-shanCHEN Zi-qianYANG Xi-zhangZHANG Hong-wenDONG Qi-longYANG Yong-yanZHUANG Xi LEI Juan
Division of Intervention Therapy,Department of Radiology,Fuzhou General Hospital,Nanjing Military District,Fuzhou350025,China
关键词:
经肝动脉化疗栓塞术腺苷蛋氨酸肝功能肝癌
分类号:
R735.7
文献标志码:
A
摘要:
目的探讨S-腺苷蛋氨酸对原发性大肝癌患者经肝动脉介入化疗栓塞(TACE)后急性肝功能损害的保护作用。方法回顾性分析自2003年5月-2007年10月我院收治的51例肝肿瘤患者进行术后护肝治疗,治疗组在TACE后静脉滴注S-腺苷蛋氨酸1000mg /d;对照组TACE后静脉滴注甘利欣30ml/d(含甘草酸二铵盐150mg )治疗。两组均在TACE术前第1天,术后第2、4、8天抽血查肝功能。结果肝功能各指标在TACE前后均发生明显变化,术后第2天ALT、AST、TBIL及DBIL均较术前不同程度的升高(P<0.05),术后第4天起各指标开始逐渐下降。治疗组总TACE前TBIL、DBIL、ALT和AST与术后第8天比较差异无统计学意义(P>0.05)。对照组ALT、AST及TBIL、DBIL在TACE术后第8天有显著升高(P<0.05)。总蛋白(TP)及白蛋白(A)TACE前与术后第8天比较无显著性差异(P>0.05)。治疗组中15例(60%)患者汉密顿抑郁量表总分出现下降。结论S-腺苷蛋氨酸对肝癌患者TACE治疗后有保护肝功能作用,近期保护急性肝损害疗效满意。S-腺苷蛋氨酸还具有一定的抗抑郁作用,可增加TACE的疗效,提高患者的生活质量。

参考文献/References:

[1]Malagari K,Alexopoulou E,Chatzimichail K,et al.Transcatheter chemoembolization in thetreatment of HCC in patients not eligible for curative treatments:midterm results of doxorubicin-loaded DC bead[J].Abdom Imaging,2007,10:379-381.
[2]Shimamura Y,Gunvèn P,Takenaka Y,et al.Combined peripheral and central chemoembolization of liver tumors.Experience with lipiodoldoxorubicin and gelatin sponge(L-TAE)[J].Cancer,1988,61:238-242.
[3]Huppert PE,Lauchart W,DTACE;SAMe ;Hepatic functionuda SH,et al.Chemoembolization of hepatocellular carcinomas:which factors determine therapeutic response and survival?[J]Rofo,2004,176:375-385.
[4]Satake M,Uchida H,Arai Y,et al.Transcatheter arterial chemoembolization(TACE)with lipiodol to treat hepatocellular carcinoma :survey results from the TACE Study Group of Japan[J].Cardiovasc Intervent Radiol,2008,4:176-182.
[5]Chuang VP,Soo CS,Carrasco CH,et al.Superselective catheterization technique in hepatic angiography[J].Am J Roentgenol,1983,141:803-811.
[6]Lieber CS.S-Adenosylmethionine in the treatment of liver dis ease[M].Bianca Volta,Truccazzano,2001.3
[7]顾昱,尹宜发,李欣等.阿拓莫兰对经肝动脉介入化疗栓塞的原发性肝癌患者肝功能的保护作用[J].临床内科杂志,2005,22:777-778.
[8]Bortolini M,Almasio P,Bray G,et al.Multicentre survey of the prevalence of intrahepatic cholestasis in2520consecutive patients with newly diagnosed chronic liver diseases[J].Drugs Invest,1992,4(supp14):83-89.
[9]Frezza M,Centini G,Cammareri G,et al.S-adenosylmethionine for the treatment of intrahepatic cholestasis of pregnancy:results of a controlled clinical trial[J].Hepatogastroenterology,1990,37(supp l2):122-125.
[10]Spillmann M,Fava M.S-adenosylmethionine(Ademetionine)in psychiatric disorders.Historical perspective and current status[J].CNS Drugs,1996,6:416-428.

备注/Memo

备注/Memo:
收稿日期:2008-06-03
更新日期/Last Update: 2008-11-15