[1]翟博,李晓燕,刘晟,等.膈顶部原发性肝癌的射频消融[J].介入放射学杂志,2009,(05):357.
　ZHAI Bo,LI Xiao-yan,LIU Sheng,et al.Radiofrequency ablation for the treatment of primary hepatocellular carcinoma located at hepatic dome[J].journal interventional radiology,2009,(05):357.
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膈顶部原发性肝癌的射频消融()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2009年05期
页码:
357
栏目:
非血管介入
出版日期:
2009-05-15

文章信息/Info

Title:
Radiofrequency ablation for the treatment of primary hepatocellular carcinoma located at hepatic dome
作者:
翟博; 李晓燕; 刘晟; 等
２００４３８上海第二军医大学附属东方肝胆外科医院超声介入科
Author(s):
ZHAI Bo; LI Xiao-yan; LIU Sheng; CHEN Yi; WU Meng-chao．
Department of Ultrasonic Intervention，Eastern Hepatobiliary Surgery Hospital，Second Military Medical University，Shanghai２００４３８，China
关键词:
原发性肝癌; 射频消融; 膈顶部
分类号:
R７３０.５；R７３５.７
文献标志码:
A
摘要:
目的探讨膈顶部原发性肝癌射频消融（RFA）的治疗转归。方法２００６年２月至２００８年３月，共有２５１例原发性肝癌患者接受了超声引导下的经皮RFA，其中４２例５６个肿瘤位于膈顶部，定义为A组。另有２０９例３６８个肿瘤位于非膈顶部，定义为B组。结果初次RFA后，A、B两组的完全消融率、局部复发率及并发症发生率分别为８５．７％比８６．６％；９．５％比１１．５％和７．１％比４．７％，差异均无统计学意义（P＞０．０５）。将B组按肿瘤具体部位进一步分为肝实质内、包膜下、空腔脏器旁以及肝门部肿瘤，再与A组比较，显示上述５个不同部位肿瘤完全消融率两组间差异有统计学意义（P＜０．０５）。膈顶部和非膈顶部直径＜３cm，３～５cm和＞５cm肿瘤的完全消融率分别为９０．２％，７６．９％，５０％和９６．６％，７８．１％，６９．２％，两组同等直径范围肿瘤的完全消融率差异无统计学意义（P＞０．０５）。A、B两组１年无复发生存率分别为６２．３％和５９．２％，总生存率分别为９０．０％和９２．０％。２年无复发生存率分别为５６．６％和５２．４％，总生存率分别为８２．７％和８４．２％。A、B两组１、２年无复发生存率和总体生存率之间差异无统计学意义（P＞０．０５）。结论尽管膈顶部肿瘤位置的特殊性影响着RFA后疾病转归，但与其他部位肿瘤相比，膈顶部肿瘤在治疗效果、治疗风险、局部复发以及生存预后方面均不逊色，膈顶部肿瘤并非RFA的禁忌证。

参考文献/References:

［１］Bowles BJ，Machi J，Limm WML，et al．Safety and efficacy of radiofrequency thermal ablation in advanced liver tumors［J］．Arch Surg，２００１，１３６：８６４-８６９．
［２］Bleicher RJ，Allegra D，Nora DT，et al．Radiofrequency ablation in４４７complex unresectable liver tumors：le

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备注/Memo

备注/Memo:
收稿日期：２００９-０２-２５
更新日期/Last Update: 2009-05-15