[1]关键,胡道予,卢凌,等.经动脉灌注５－FU缓释微球治疗兔VX２肝肿瘤[J].介入放射学杂志,2008,(11):799.
　GUAN Jian,HU Daoyu,LU Ling,et al.Experimental study of transarterial infusion with５－FU sustained－release microspheres for rabbit hepatic VX２tumors[J].journal interventional radiology,2008,(11):799.
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经动脉灌注５－FU缓释微球治疗兔VX２肝肿瘤()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2008年11期
页码:
799
栏目:
实验研究
出版日期:
2008-11-15

文章信息/Info

Title:
Experimental study of transarterial infusion with５－FU sustained－release microspheres for rabbit hepatic VX２tumors
作者:
关键; 胡道予; 卢凌; 等
４３００３０武汉华中科技大学同济医学院附属同济医院放射科（关键、胡道予、潘初）；肝脏外科中心（卢凌、徐涛）
Author(s):
GUAN Jian; HU Dao－yu; LU Ling; XU Tao; PAN Chu
Department of Radiology，Affiliated Tongji Hospital，Hua Zhong Science and Technology University，Wuhan４３００３０，China
关键词:
肝肿瘤; VX２肿瘤; 缓释微球; 凋亡; 化疗栓塞
分类号:
R７３－３６
文献标志码:
B
摘要:
目的研究５－FU缓释微球经胃十二指肠动脉灌注对兔VX２肝肿瘤的治疗作用。方法将成功接种肝VX２肿瘤的模型兔随机分成４组，每组１０只，用显微外科手术临时阻断肝总动脉血流，经胃十二指肠动脉插管至肝固有动脉起始部给药行介入治疗，术毕结扎胃十二指肠动脉。A组（生理盐水对照组），注射生理盐水０．５～１ml ；B组（碘佛醇对照组）注射碘佛醇０．５～１ml ；C组为碘油组（疗效对比组），注射超液化碘油０．５～１．０ml ；D组为５－FU缓释微球组，注射５－FU缓释微球１０mg 和碘佛醇１ml 混合溶液。４组实验动物于治疗１周后观察肿瘤生长情况、坏死程度，并采用原位末端标记法（TUNEL）检测肿瘤细胞凋亡指数（AI）。结果治疗１周后５－FU缓释微球组肿瘤生长受到抑制，肿瘤生长率低于生理盐水对照组和碘佛醇对照组（P﹤０．０５），与碘油组差异无统计学意义（P＞０．０５）。４组肿瘤均有不同程度坏死，５－FU缓释微球组和碘油组肿瘤坏死率明显高于另两组（P＜０．０５）。生理盐水对照组、碘佛醇对照组和５－FU缓释微球组肿瘤细胞凋亡指数分别为１．６９±０．１８、１．７５±０．２７和８．０３±０．６３，５－FU缓释微球组与各对照组相比差异有统计学意义（P＜０．０５）。结论５－FU缓释微球经动脉灌注可抑制肝肿瘤生长，诱导肿瘤细胞凋亡，促进肿瘤坏死，是有效的化疗栓塞剂。

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备注/Memo

备注/Memo:
收稿日期：２００８－０６－２４
更新日期/Last Update: 2008-11-15