[1]贺克武,高斌,李嘉嘉.CT导引下125Ⅰ粒子植入治疗兔VX2肿瘤的实验研究[J].介入放射学杂志,2008,(06):428.
 HE Kewu,GAO Bin,LI Jiajia.Study of CT-guided iodine-125implantation in the treatment of rabbit VX2tumor[J].journal interventional radiology,2008,(06):428.
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CT导引下 125 Ⅰ粒子植入治疗兔VX2肿瘤的实验研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2008年06期
页码:
428
栏目:
实验研究
出版日期:
2008-06-15

文章信息/Info

Title:
Study of CT-guided iodine-125implantation in the treatment of rabbit VX2tumor
作者:
贺克武高斌李嘉嘉
:230061合肥市第一人民医院影像中心(贺克武,高斌);安徽医科大学第一附属医院中心实验室(李嘉嘉)
Author(s):
HE Ke-wuGAO BinLI Jia-jia.
Medical Imaging Center,Hefei Municipal First People 's Hospital,Hefei230061,China
关键词:
肿瘤细胞VX2肿瘤碘放射性核素近距离疗法体层摄影术X线计算机
分类号:
R73.36
文献标志码:
B
摘要:
目的探讨CT导引下 125 I粒子组织间植入兔VX2肿瘤模型对细胞凋亡率的影响。方法在20只兔两侧大腿肌肉内建立VX2肿瘤模型,3周后待肿瘤灶长至直径约2cm备用,每只兔随机选择一侧肿瘤灶作为治疗侧,另一侧作为对照侧,治疗侧在CT导引下经皮穿刺将活度为0.9mCi 的 125 Ⅰ粒子植入肿瘤组织内,对照侧肿瘤灶内植入无活性的空心粒子,于术后即刻、72h、1、2、3周在CT导引下分别穿刺距粒子0.5~1cm、1.0~1.5cm处组织检测细胞凋亡率。结果 125 Ⅰ粒子植入后即刻、72h、1、2、3周距粒子0.5~1.0cm处对照侧和治疗侧细胞凋亡率分别为(5.43±0.67)%和(5.48±0.66)%(P>0.05),(5.45±0.58)%和(11.60±0.87)%(P<0.05),(6.07±0.69)%和(18.8±0.64)%(P<0.05),(5.94±0.43)%和(37.20±0.39)%(P<0.01),(6.30±0.58)%和(36.56±0.67)%(P<0.01)。距 125 Ⅰ粒子1.0~1.5cm处各个时间点对照侧与实验侧细胞凋亡率差别均无统计学意义(P>0.05)。结论 125 Ⅰ粒子组织间植入可诱导肿瘤细胞凋亡,植入后72h细胞凋亡率开始增加,术后2周达高峰并维持在高水平,且随距 125 Ⅰ粒子的距离增加,细胞凋亡率迅速下降。

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2007-12-04
资助项目:合肥市重点科研立项项目(2006004);合肥市人才发展基金资助项目
更新日期/Last Update: 2008-06-15