[1]贾中芝,谢双双,郑丽丽,等.钇-90微球的剂量计算——钇-90微球放射栓塞系列回顾（四）[J].介入放射学杂志,2018,27(01):91-95.
　JIA Zhongzhi,XIE Shuangshuang,ZHENG Lili,et al.Series review of radioembolization with yttrium- 90 microspheres（Part Ⅳ）： dose calculation of yttrium- 90 microspheres[J].journal interventional radiology,2018,27(01):91-95.
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钇-90微球的剂量计算——钇-90微球放射栓塞系列回顾（四）()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
27
期数:
2018年01期
页码:
91-95
栏目:
讲 座
出版日期:
2018-01-25

文章信息/Info

Title:
Series review of radioembolization with yttrium- 90 microspheres（Part Ⅳ）： dose calculation of yttrium- 90 microspheres
作者:
贾中芝;  谢双双;  郑丽丽;  王斯妮;  王维平
Author(s):
JIA Zhongzhi;  XIE Shuangshuang;  ZHENG Lili;  WANG Sini;  WANG Weiping
Department of Interventional Radiology， Affiliated Changzhou Municipal No.2 People’s Hospital， Nanjing Medical University， Changzhou， Jiangsu Province 213003， China
关键词:
【关键词】 钇-90;  剂量;  肺分流百分数;  肿瘤负荷
文献标志码:
A
摘要:
【摘要】 精确的钇-90（90Y）微球剂量对治疗肝脏恶性肿瘤至关重要，这与临床疗效和不良反应密切相关。剂量的计算主要基于不同的90Y载体：玻璃微球（TheraSpheres）或树脂微球（SIR- Spheres）。玻璃微球的剂量是以肝脏预期的辐射剂量和微球能够均匀分布于整个肝脏的假设为基础计算的，而树脂微球的剂量是以微球非均匀分布于整个肝脏的假设为基础计算的，这种非均匀分布的程度取决于正常肝脏被肿瘤组织取代的程度。许多其他因素也可能会潜在影响90Y微球的治疗剂量。本综述将介绍90Y微球剂量的计算方法，以及为了获得最大疗效并尽量避免不良反应发生而需要考虑的各种因素。

参考文献/References:

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［2］ Salem R， Thurston KG. Radioembolization with 90 yttrium microspheres： a state- of- the- art brachytherapy treatment for primary and secondary liver malignancies. Part 1： Technical and methodologic considerations［J］. J Vasc Interv Radiol， 2006， 17： 1251- 1278.
［3］ Salem R， Thurston KG. Radioembolization with 90 yttrium microspheres： a state- of- the- art brachytherapy treatment for primary and secondary liver malignancies. Part 2： Special topics［J］. J Vasc Interv Radiol， 2006， 17： 1425- 1439.
［4］ Salem R， Thurston KG. Radioembolization with yttrium- 90 microspheres： a state- of- the- art brachytherapy treatment for primary and secondary liver malignancies. Part 3： Comprehensive literature review and future direction［J］. J Vasc Interv Radiol， 2006， 17： 1571- 1593.
［5］ Murthy R， Nunez R， Szklaruk J， et al. Yttrium- 90 microsphere therapy for hepatic malignancy： devices， indications， technical considerations， and potential complications［J］. Radiographics， 2005， 25（Suppl 1）： S41- S55.
［6］ Padia SA， Lewandowski RJ， Johnson GE， et al. Radioembolization of hepatic malignancies： background， quality improvement guidelines， and future directions［J］. J Vasc Interv Radiol， 2017， 28： 1- 15.
［7］ Ho S， Lau WY， Leung TW， et al. Clinical evaluation of the partition model for estimating radiation doses from yttrium- 90 microspheres in the treatment of hepatic cancer［J］. Eur J Nucl Med， 1997， 24： 293- 298.

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备注/Memo

备注/Memo:
（收稿日期：２０１7-０7-28）
（本文编辑：俞瑞纲）
更新日期/Last Update: 2018-01-26