[1]刘 蓉,马士新,赵 钢,等.紫杉醇药物涂层球囊扩张冠状动脉支架内再狭窄病变增加远期管腔面积 [J].介入放射学杂志,2017,(04):367-369.
　LIU Rong,MA Shixing,ZHAO Gang,et al.Long- term lumen area enlarged in coronary in- stent restenosis after the treatment of paclitaxel drug - coated balloon dilatation[J].journal interventional radiology,2017,(04):367-369.
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紫杉醇药物涂层球囊扩张冠状动脉支架内再狭窄病变增加远期管腔面积
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2017年04期
页码:
367-369
栏目:
临床研究
出版日期:
2017-04-25

文章信息/Info

Title:
Long- term lumen area enlarged in coronary in- stent restenosis after the treatment of paclitaxel drug - coated balloon dilatation
作者:
刘 蓉;  马士新;  赵 钢;  杭靖宇;  魏 盟;  陆志刚
Author(s):
LIU Rong;  MA Shixing;  ZHAO Gang;  HANG Jingyu;  WEI Meng;  LU Zhigang
Department of Cardiology， Affiliated Sixth People’s Hospital of Shanghai Jiaotong University， Shanghai 200233， China
关键词:
【关键词】 药物涂层球囊;  支架内再狭窄;  远期管腔面积扩张
文献标志码:
A
摘要:
【摘要】 目的 探讨以单纯紫杉醇药物涂层球囊（DCB）扩张冠状动脉介入治疗术后支架内再狭窄（ISR）病变段，观察远期靶血管管腔面积，从而证实DCB在ISR病变中的作用。方法 选取4例符合DCB适应证ISR患者，按照标准流程在充分预扩张基础上予以紫杉醇DCB扩张病变段，不植入支架。术后即刻及术后9个月采用冠状动脉造影和血管内超声检测患者最小管腔横截面积（MLA）、支架横截面积（SA）和血管内膜增生状况。结果 4例患者单纯紫杉醇DCB治疗后即刻造影显示靶血管扩张段无夹层，无明显残余狭窄。术后9个月造影显示所有患者靶血管扩张段管腔通畅，病变段未见明显再狭窄，TIMI血流3级；血管内超声检测显示MLA均较术后即刻显著增加，SA呈增加趋势，内膜增生呈抑制趋势。结论 单纯DCB扩张ISR病变可增加远期管腔面积，避免二次支架植入，降低再次ISR风险，并通过局部释放紫杉醇作用于管壁，抑制内膜过度增生。

参考文献/References:

［1］ 潘春仰， 邱建平， 陆 林， 等． 冠状动脉介入治疗后支架内再狭窄相关因素［J］． 介入放射学杂志， 2015， 24： 467- 471．
［2］ Cremers B， Toner JL， Schwartz LB， et al. Inhibition of neointimal hyperplasia with a novel zotarolimus coated balloon catheter［J］. Clin Res Cardiol， 2012， 101： 469- 476.
［3］ Cremers B， Kelsch B， Clever YP， et al. Inhibition of neointimal proliferation after bare metal stent implantation with low- pressure drug delivery using a paclitaxel- coated balloon in porcine coronary arteries［J］. Clin Res Cardiol， 2012， 101： 385- 391.
［4］ 付 强， 苗志林， 李占全． 药物洗脱球囊的研究进展［J］． 中国介入心脏病学杂志， 2011， 19： 111- 113．
［5］ Kleber FX， Schulz A， Waliszewski M， et al. Local paclitaxel induces late lumen enlargement in coronary arteries after balloon angioplasty［J］. Clin Res Cardiol， 2015， 104： 217- 225.
［6］ Scheller B， Hehrlein C， Bocksch W， et al. Treatment of coronary in- stent restenosis with a paclitaxel- coated balloon catheter［J］. N Engl J Med， 2006， 355： 2113- 2124.
［7］ Unverdorben M， Vallbracht C， Cremers B， et al. Paclitaxel- coatedballoon catheter versus paclitaxel- coated stent for the treatmentof coronary in- stent restenosis［J］. Circulation， 2009， 119： 2986- 2994.
［8］ Navarese EP， Austin D， Gurbel PA， et al. Drug- coated balloons in treatment of in- stent restenosis： a meta- analysis of randomised controlled trials［J］. Clin Res Cardiol， 2013， 102： 279- 287.
［9］ Kleber FX， Mathey DG， Rittger H， et al. How to use the drug- eluting balloon： recommendations by the German consensus group［J］. EuroIntervention， 2011， 7（Suppl K）： K125- K128.
［10］ Kleber FX， Rittger H， Bonaventura K， et al. Drug- coated balloons for treatment of coronary artery disease： updated recommenda- tions from a consensus group［J］. Clin Res Cardiol， 2013， 102： 785- 797.
［11］ Bonaventura K， Leber AW， Sohns C， et al. Cost- effectiveness of paclitaxel- coated balloon angioplasty and paclitaxel- eluting stent implantation for treatment of coronary in- stent restenosis in patients with stable coronary artery disease［J］. Clin Res Cardiol， 2012， 101： 573- 584.
［12］ Haude M， Erbel R， Issa H， et al. Quantitative analysis of elastic recoil after balloon angioplasty and after intracoronary implantation of balloon- expandable Palmaz- Schatz stents［J］. J Am Coll Cardiol， 1993， 21： 26- 34.
［13］ Holmes DR Jr， Vlietstra RE， Smith HC， et al. Restenosis after percutaneous transluminal coronary angioplasty （PTCA）： a report from the PTCA Registry of the National Heart， Lung， and Blood Institute［J］. Am J Cardiol， 1984， 53： 77C- 81C.
［14］ 《药物涂层球囊临床应用中国专家共识》专家组. 药物涂层球囊临床应用中国专家共识［J］. 中国介入心脏病学杂志， 2016， 24： 61- 67.
［15］ Pires NM， Eefting D， de Vries MR， et al. Sirolimus and paclitaxel provoke different vascular pathological responses after local delivery in a murine model for restenosis on underlying atherosclerotic arteries［J］. Heart， 2007， 93： 922- 927.

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备注/Memo

备注/Memo:
（收稿日期：２０１6-０6-27）
（本文编辑：边 佶）
更新日期/Last Update: 2017-04-11