[1]丁海霞,王富军,马红芳,等.脐带血干细胞移植对兔糖尿病后肢血管病变介入术后支架内再狭窄的影响[J].介入放射学杂志,2016,(08):695-698.
　DING Hai-xia,WANG Fu-jun,MA Hong-fang,et al.The effect of umbilical cord blood stem cell transplantation on the in-stent restenosis after intervention therapy for diabetic vascular diseases in experimental rabbits [J].journal interventional radiology,2016,(08):695-698.
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脐带血干细胞移植对兔糖尿病后肢血管病变介入术后支架内再狭窄的影响 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2016年08期
页码:
695-698
栏目:
实验研究
出版日期:
2016-08-25

文章信息/Info

Title:
The effect of umbilical cord blood stem cell transplantation on the in-stent restenosis after intervention therapy for diabetic vascular diseases in experimental rabbits

作者:
丁海霞;  王富军;  马红芳;  杜亚萍;  齐会卿;  丁 娟
Author(s):
DING Hai-xia;  WANG Fu-jun;  MA Hong-fang;  DU Ya-ping;  QI Hui-qing;  DING Juan
Department of Endocrinology, Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei Province 050011, China
关键词:
【关键词】 脐带血干细胞;  支架内再狭窄;  血管内介入治疗;  糖尿病血管病变
文献标志码:
A
摘要:
【摘要】 目的 观察脐带血干细胞移植对糖尿病实验兔后肢血管病变血管内介入术后支架内再狭窄的影响。 方法 制备糖尿病后肢血管病变兔模型22只,随机分成A组( n =8, 介入术联合脐带血干细胞移植)、B组( n =8,单纯介入术)、C组( n =6,未治疗干预)、D组( n =6, 未制模，为正常对照)。采用酶联免疫吸附试验分别测定血清血管内皮钙黏蛋白(VE-cadherin)和血浆脂蛋白相关磷脂酶A2(Lp-PLA2)水平,苏木精-伊红染色测定新生内膜面积及内膜面积与中膜面积比值。 结果 治疗后A组VE-cadherin 和Lp-PLA2水平明显低于B、C组( P 均＜0.01),与D组比较差异无统计学意义( P＞ 0.05)。A组兔股动脉有轻度内膜中断和增生,弹力膜轻度断裂；A组内膜面积、内膜面积与中膜面积比值均显著小于B、C组( P 均＜0.05),与D组比较差异无统计学意义( P＞ 0.05)。 结论 脐带血干细胞移植可有效保护血管内介入术后血管内皮损伤,预防术后支架内再狭窄。

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备注/Memo

备注/Memo:
(收稿日期：2015-10-26)
(本文编辑：边 佶)
更新日期/Last Update: 2016-08-23