[1]应希慧,纪建松,涂建飞,等.表皮生长因子受体酪氨酸激酶抑制剂联合放射性粒子植入治疗肺癌的疗效分析[J].介入放射学杂志,2015,(03):226-230.
 YING Xi hui,JI Jian song,TU Jian fei,et al.EGFR TKIS combined with radioactive 125I seed implantation for the treatment of advanced non small cell lung cancer: analysis of clinical effect[J].journal interventional radiology,2015,(03):226-230.
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表皮生长因子受体酪氨酸激酶抑制剂联合放射性粒子植入治疗肺癌的疗效分析 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年03期
页码:
226-230
栏目:
非血管介入
出版日期:
2015-03-25

文章信息/Info

Title:
EGFR TKIS combined with radioactive 125I seed implantation for the treatment of advanced non small cell lung cancer: analysis of clinical effect
作者:
应希慧 纪建松 涂建飞 赵中伟 宋晶晶 张登科 吴敏华
Author(s):
YING Xi hui JI Jian song TU Jian fei ZHAO Zhong wei SONG Jing jing ZHANG Deng ke WU Min hua.
Department of Interventional Radiology, Lishui Municipal Central Hospital, Lishui, Zhejiang Province 323000, China
关键词:
【关键词】 非小细胞肺癌 表皮生长因子受体酪氨酸激酶抑制剂 125I放射性粒子
文献标志码:
A
摘要:
【摘要】 目的 探讨表皮生长因子受体酪氨酸激酶抑制剂(EGFR TKIS)联合125I放射性粒子植入治疗晚期非小细胞肺癌(NSCLC)的近期疗效和安全性。方法 48例ⅢB~Ⅳ期不可手术切除的、EGFR突变阳性的晚期NSCLC患者,分成A、B两组,A组26例,行EGFR TKIS联合125I放射性粒子植入治疗;B组22例单纯行EGFR TKIS治疗,直至进展,对比分析两组患者的疗效、不良反应发生率及生存率。结果 A、B两组患者局部控制率分别为92.3%和68.2%,差异有统计学意义(P = 0.033);治疗有效率分别76.9%和54.5%,差异无统计学意义(P = 0.101)。研究组与对照组无进展生存时间(PFS)分别为14.1和 9.7个月;1年生存率分别为80.8%和63.6%,中位生存时间分别为26.9和 17.1个月,差异均有统计学意义(P < 0.05)。125I放射性粒子植入的主要并发症为气胸。结论 EGFR TKIS联合125I放射性粒子植入治疗EGFR突变的晚期NSCLC是一种安全、有效的疗法,短期疗效优于单纯EGFR TKIS药物治疗,是现阶段治疗EGFR突变的晚期NSCLC患者的新选择。

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备注/Memo

备注/Memo:
(收稿日期:2014-10-28)
(本文编辑:俞瑞纲 )
更新日期/Last Update: 2015-03-29