[1]陆 健,刘 琳,陈志瑾,等.进展期非小细胞肺癌125I粒子植入前后CEA、 CYFRA21- 1变化与临床疗效评估[J].介入放射学杂志,2016,(03):234-238.
 LU Jian,LIU Lin,CHEN Zhi- jin,et al.The changes of CEA and CYFRA21- 1 levels after 125I seed implantation in advanced non- small cell lung cancer and their correlation with clinical effectiveness[J].journal interventional radiology,2016,(03):234-238.
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进展期非小细胞肺癌125I粒子植入前后CEA、 CYFRA21- 1变化与临床疗效评估 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2016年03期
页码:
234-238
栏目:
非血管介入
出版日期:
2016-03-25

文章信息/Info

Title:
The changes of CEA and CYFRA21- 1 levels after 125I seed implantation in advanced non- small cell lung cancer and their correlation with clinical effectiveness
作者:
陆 健 刘 琳 陈志瑾 王忠敏 程英升 贡 桔 夏 宁
Author(s):
LU Jian LIU Lin CHEN Zhi- jin WANG Zhong- min CHENG Ying- sheng GONG Ju XIA Ning
Medical College of Soochow University, Suzhou, Jiangsu Province 215123, China
关键词:
【关键词】 非小细胞肺癌 CT引导 125I粒子 肿瘤标志物
文献标志码:
A
摘要:
【摘要】 目的 观察CT引导下125I 放射性粒子组织间植入治疗进展期非小细胞肺癌(NSCLC)的临床疗效及125I粒子植入前后血清癌胚抗原(CEA)和细胞角质素片段抗原(CYFRA21- 1)的动态水平。方法 对28例不能手术切除的进展期NSCLC患者施行CT引导下植入125I 放射性粒子,并用放射免疫方法测定125I 放射性粒子植入治疗前后的患者血清CEA和CYFRA21- 1水平。结果 治疗后随访1~37个月,全组中位生存时间为17个月,1、2和3年生存率分别为72.0%、30.8%、6.2%。中位局部控制时间为15.5个月,1年、2年的年局部控制率分别为58.0%、20.3%。125I 粒子植入后1、3个月,患者血清中CEA和CYFRA21- 1水平与植入前比较有明显下降(P<0.05)。治疗后CEA降低组死亡率53.9%,升高组死亡率86.7%(P=0.055);治疗后CYFRA21- 1降低组死亡率36.4%,升高组死亡率94.1%(P=0.001)。结论 CT引导下植入125I 放射性粒子治疗进展期NSCLC,临床近期疗效确切,是一种安全、有效、并发症少的介入治疗方法;且能有效降低CEA和CYFRA21- 1水平,肿瘤标志物水平的监测有助于预测患者的预后。

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备注/Memo

备注/Memo:

(收稿日期:2015-10-19)
(本文编辑:俞瑞纲)

更新日期/Last Update: 2016-03-22