[1]宋晶晶,纪建松,赵中伟,等. 支气管动脉化疗栓塞联合125I粒子植入治疗老年性非小细胞肺癌疗效分析[J].介入放射学杂志,2014,(02):159-163.
 SONG Jing? jing,JI Jian? song,ZHAO Zhong? wei,et al. Bronchial artery chemoembolization combined with 125I seeds implantation for the treatment of non?蛳 small cell lung cancer in senile patients: comparison with GP chemotherapy scheme[J].journal interventional radiology,2014,(02):159-163.
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 支气管动脉化疗栓塞联合125I粒子植入治疗老年性非小细胞肺癌疗效分析 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2014年02期
页码:
159-163
栏目:
临床研究
出版日期:
2014-02-28

文章信息/Info

Title:
 Bronchial artery chemoembolization combined with 125I seeds implantation for the treatment of non?蛳 small cell lung cancer in senile patients: comparison with GP chemotherapy scheme
作者:
宋晶晶 纪建松 赵中伟 范晓希 张登科
Author(s):
 SONG Jing?蛳 jing JI Jian?蛳 song ZHAO Zhong?蛳 wei FAN Xiao?蛳 xi ZHANG Deng?蛳 ke.
 Department of Interventional Radiology, Lishui Municipal Central Hospital, Lishui, Zhejiang Province 323000, China
关键词:
 【关键词】 非小细胞肺癌 支气管动脉化疗栓塞 125I放射性粒子 化疗
文献标志码:
A
摘要:
 【摘要】 目的 探讨支气管动脉化疗栓塞联合125I放射性粒子植入治疗老年性非小细胞肺癌(NSCLC)的安全性、有效性,并与吉西他滨联合顺铂(GP)方案化疗的近期疗效进行对比分析。方法 82例Ⅲa ~ Ⅲb期不可手术切除的老年性NSCLC患者随机分成两组,研究组38例,行支气管动脉化疗栓塞联合125I放射性粒子植入治疗3 ~ 6个疗程;对照组44例行GP方案4 ~ 6个疗程全身静脉化疗,对比分析两组患者的疗效、不良反应发生率及生存率。结果 研究组和对照组患者的治疗有效率分别为71.1%和43.2%(P < 0.05),差异有统计学意义。局部控制率分别为84.2%和64.1%,差异无统计学意义(P > 0.05)。研究组与对照组1年生存率分别为71.1%和52.1%,中位生存时间分别为399 d和336 d,差异均有统计学意义(P均 < 0.05)。研究组的不良反应率明显比对照组低,差异有统计学意义(P < 0.05),其中125I放射性粒子植入的主要并发症为气胸。结论 支气管动脉化疗栓塞联合125I放射性粒子植入治疗不可手术切除的Ⅲ期老年性NSCLC是一种安全、有效的治疗方法,毒副作用低,短期疗效优于GP方案化疗,是现阶段治疗老年晚期NSCLC患者的新选择。

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 (收稿日期:2013?鄄09?鄄18)
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