[1]刘 亚,吕维富,成德雷,等.静脉化疗联合125I放射性粒子植入治疗中晚期非小细胞肺癌的疗效评价 [J].介入放射学杂志,2018,27(10):966-971.
 LIU Ya,LV Weifu,CHENG Delei,et al.Efficacy evaluation of intravenous chemotherapy combined with 125I seed implantation in treating advanced non- small cell lung cancer[J].journal interventional radiology,2018,27(10):966-971.
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静脉化疗联合125I放射性粒子植入治疗中晚期非小细胞肺癌的疗效评价 
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
27
期数:
2018年10期
页码:
966-971
栏目:
临床研究
出版日期:
2018-10-25

文章信息/Info

Title:
Efficacy evaluation of intravenous chemotherapy combined with 125I seed implantation in treating advanced non- small cell lung cancer
作者:
刘 亚 吕维富 成德雷 周春泽 刘开才 方伟伟
Author(s):
LIU Ya LV Weifu CHENG Delei ZHOU Chunze LIU Kaicai FANG Weiwei.
Department of Radiology, Hefei Municipal Third People’s Hospital, Hefei, Anhui Province 230022, China
关键词:
【关键词】 非小细胞肺癌 静脉化疗 125I粒子
文献标志码:
A
摘要:
【摘要】 目的 评价静脉化疗联合125I粒子植入治疗中晚期非小细胞肺癌(NSCLC)的疗效。方法 回顾性分析85例NSCLC患者,根据治疗方法不同分为两组:联合组42例,行静脉化疗联合125I粒子植入治疗;对照组43例,行单纯静脉化疗。比较两组治疗后血清肿瘤标志物、血常规、患者术后生存质量、并发症、局部有效率及远期生存率差异。结果 联合组术后3个月总有效率为71.4%,明显高于对照组39.5%(P<0.05),联合组术后3个月鳞癌有效率为64.7%,腺癌有效率为76.0%;对照组静脉化疗后3个月鳞癌有效率为41.2%,腺癌有效率为38.5%。联合组患者中位生存时间为14.7个月,对照组为7.6个月,联合组1、2年累积生存率分别为59.2%、28.6%,对照组为34.6%、14.0%,联合组生存率明显优于对照组(χ2=5.503,P=0.019)。Ⅲb期联合组患者中位生存期15.9个月,对照组为8.3个月,联合组1、2年累积生存率为68.0%、36.0%,对照组1、2年累积生存率为38.5%、15.4%,Ⅲb期联合组生存率高于对照组(χ2=5.934,P=0.015)。Ⅳ期联合组中位生存期为8.6个月,对照组为6.3个月,联合组1、2年累积生存率为45.8%、17.6%,对照组1、2年累积生存率为22.1%、11.8%,Ⅳ期联合组2年累积生存率与对照组差异无统计学意义(χ2=1.446,P=0.229)。联合组术后1个月CEA下降水平明显高于对照组(P<0.05)。联合组治疗后血常规与术前比较,差异均无统计学意义(P>0.05)。结论 静脉化疗联合125I放射性粒子治疗中晚期NSCLC是安全、有效的介入治疗方法。

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备注/Memo

备注/Memo:
(收稿日期:2018-01-08)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2018-10-15