[1]卢川,谢谦宇,刘林祥.血管结扎结合弹力酶诱导法兔动脉瘤模型的制作[J].介入放射学杂志,2010,(09):722.
　LU Chuan,XIE Qianyu,LIU Linxiang.The preparation of aneurysm model in rabbits by vessel ligation and elastase－induced technique[J].journal interventional radiology,2010,(09):722.
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血管结扎结合弹力酶诱导法兔动脉瘤模型的制作()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2010年09期
页码:
722
栏目:
实验研究
出版日期:
2010-09-15

文章信息/Info

Title:
The preparation of aneurysm model in rabbits by vessel ligation and elastase－induced technique
作者:
卢川; 谢谦宇; 刘林祥
２７１０１６泰安山东省泰山医学院放射学院（卢川、刘林祥）；湖南省长沙市第三人民医院介入科（谢谦宇）
Author(s):
LU Chuan; XIE Qian－yu; LIU Lin－xiang．
School of Radiology，Taishan Medical College，Taian２７１０１６，China Corresponding author：LU Chuan，E－mail：michaellu８９＠sina．com．cn
关键词:
动脉瘤; 动物模型; 结扎; 弹力酶; 兔
分类号:
R５４３.５
文献标志码:
A
摘要:
目的用血管结扎结合弹力酶诱导法制作形态学更类似于人颅内动脉瘤的兔动脉瘤动物模型。方法分别将１０只新西兰大白兔用血管结扎结合弹力酶诱导法和６只新西兰大白兔用外科缝合法制作出两种兔动脉瘤模型。１周和１个月后分别经股动脉行动脉瘤模型DSA检查，观察动脉瘤的通畅率、形态变化和病理改变。结果两种方法制作出的动脉瘤充盈良好；１周后造影显示：１０个用血管结扎法制作的动脉瘤模型全部通畅；６个用外科缝合法制作动脉瘤模型仅见２个动脉瘤显影，４个动脉瘤均闭塞。１个月后造影检查显示：１０个用血管结扎法制作动脉瘤仍保持通畅；２个用外科缝合法制作通畅的动脉瘤均闭塞。造模后和其后１个月血管结扎法制作的动脉瘤宽径和长径分别是（３．７０±０．１６）mm、（６．５３±０．６５）mm和（５．０６±０．３１）mm、（９．０±０．５２）mm（P＜０．０５）。病理结果显示：动脉瘤模型动脉壁内弹力层和中弹力层基本缺失。结论用血管结扎法制作出的动脉瘤模型通畅率高、具有自发生长的特征，其形态学和人类颅内动脉瘤类似。

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期：２０１０－０２－１１
更新日期/Last Update: 2010-09-15