[1]朱悦琦,李明华,谢剑,等.Willis覆膜支架治疗犬颈内动脉虹吸段动脉瘤的影像学和组织病理学研究[J].介入放射学杂志,2010,(04):302.
　ZHU Yueqi,LI Minghua,XIE Jian,et al.Treatment of carotid－siphon aneurysms by using Willis stent－graft：an angiographic and histopathologic study in dogs[J].journal interventional radiology,2010,(04):302.
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Willis覆膜支架治疗犬颈内动脉虹吸段动脉瘤的影像学和组织病理学研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2010年04期
页码:
302
栏目:
实验研究
出版日期:
2010-04-15

文章信息/Info

Title:
Treatment of carotid－siphon aneurysms by using Willis stent－graft：an angiographic and histopathologic study in dogs
作者:
朱悦琦; 李明华; 谢剑; 等
２００２３３上海交通大学医学院附属第六人民医院放射科（朱悦琦、李明华、谢剑、谭华桥、王建波）；上海同济大学医学院附属第十人民医院放射科（程英升）
Author(s):
ZHU Yue－qi ; LI Ming－hua; XIE Jian; TAN Hua－qiao; CHENG Ying－sheng; WANG Jian－bo
the Affiliated Sixth People 's Hospital，School of Medicine，Shanghai Jiaotong University，Shanghai２００２３３，China
关键词:
覆膜支架; 颅内动脉瘤; 动物模型; 颈动脉虹吸段
分类号:
R５４３.４
摘要:
目的建立一种犬颈动脉虹吸段（CS）动脉瘤模型，并观察１２个月以测试新型Willis颅内覆膜支架系统的机械性能；评价植入支架在弯曲段血管内的组织学反应。方法通过外科手术方法建立１２只犬２４枚颈动脉直段侧壁囊性动脉瘤（A组），和１２只犬１２枚CS动脉瘤（B组）。每枚动脉瘤行１枚覆膜支架植入治疗。以血管造影方法评价支架植入即刻，１、３、６和１２个月随访动脉瘤闭塞、支架内漏、支架成角、载瘤动脉是否通畅及再狭窄率等情况。支架段血管行光镜和扫描电镜检查，评价动脉瘤腔内血栓形成，内膜增生和内皮化情况。结果B组中，支架植入即刻血管造影显示２枚动脉瘤存在轻度内漏，３枚支架存在轻度成角现象；１２个月时随访，内漏均消失，１支载瘤动脉发生闭塞，３支载瘤动脉有轻度狭窄（＜５０％）。A组中，１支载瘤动脉闭塞，２支载瘤动脉轻度狭窄（＜５０％）。电镜检查所有支架内均有新生内膜形成，动脉瘤腔内均充满血栓。B组动物，１２个月时才完成完全内皮化过程，内皮细胞排列与血流动力学方向具有很强的相关性。结论应用Willis覆膜支架治疗犬CS动脉瘤方法学上可行。与直段血管相比，弯曲段血管内覆膜支架植入后，支架内皮化时间延长。

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备注/Memo

备注/Memo:
收稿日期：２０１０－０１－２６
更新日期/Last Update: 2010-04-15