[1]郑家平,邵国良,罗 君,等. 索拉非尼治疗中晚期肝细胞癌安全性和预后因素分析[J].介入放射学杂志,2014,(03):222-225.
 ZHENG Jia? ping,SHAO Guo? liang,LUO Jun,et al. Sorafenib for the treatment of intermediate?蛳 advanced hepatocellular carcinomas: its safety and prognostic factors[J].journal interventional radiology,2014,(03):222-225.
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 索拉非尼治疗中晚期肝细胞癌安全性和预后因素分析 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2014年03期
页码:
222-225
栏目:
肿瘤介入
出版日期:
2014-03-25

文章信息/Info

Title:
 Sorafenib for the treatment of intermediate?蛳 advanced hepatocellular carcinomas: its safety and prognostic factors
作者:
 郑家平 邵国良 罗 君 陈玉堂 姚 征 曾 晖 郝伟远

Author(s):
 ZHENG Jia?蛳 ping SHAO Guo?蛳 liang LUO Jun CHEN Yu?蛳 tang YAO Zheng ZENG Hui HAO Wei?蛳 yuan.
 Department of Interventional Radiology, Zhejiang Provincial Cancer Hospital, Hangzhou, Zhejiang Province 310022, China
关键词:
【关键词】 癌肝细胞 索拉非尼 治疗
文献标志码:
A
摘要:
 【摘要】 目的 探讨索拉非尼治疗中晚期肝细胞癌(HCC)的安全性及影响预后的因素。方法 2006年2月—2012年12月,89例中晚期HCC患者接受索拉非尼靶向治疗。采用单因素和多因素分析患者各项临床病理学参数与其预后的关系,并观察索拉非尼相关不良反应。结果 74例患者可作疗效评价,死亡45例,存活27例,失访2例。疾病控制率(DCR)85.14%。中位肿瘤进展时间(mTTP)6.53个月(95%CI:4.79 ~ 8.26个月),中位总生存时间(mOS)9.93个月(95%CI:8.13 ~ 11.74个月)。单因素分析发现,PS评分、Child?蛳 Pugh分级、BCLC分期、肿瘤血管侵犯及不同的治疗模式对预后的影响有统计学意义。进一步多因素分析发现,Child?蛳 Pugh分级和治疗模式是患者预后的独立影响因素(P < 0.05)。服用索拉非尼主要不良反应为手足皮肤反应、消化道不良反应、乏力、骨髓抑制等。结论 肝功能良好的HCC患者采用TACE术后序贯索拉非尼治疗可获得较长的生存时间和疾病稳定状态。口服索拉非尼不良反应大多可以耐受。

参考文献/References:

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备注/Memo

备注/Memo:
 (收稿日期:2013-05-08)
更新日期/Last Update: