[1]韩聚强,范公忍,任永强,等. 不同微创介入治疗原发性肝癌对机体T细胞免疫功能的影响[J].介入放射学杂志,2014,(03):218-221.
 HAN Ju? qiang,FAN Gong? ren,REN Yong? qiang,et al. The influence of different micro?蛳 injury interventional treatments on the T lymphocyte immune function in patients with primary hepatocellular carcinoma[J].journal interventional radiology,2014,(03):218-221.
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 不同微创介入治疗原发性肝癌对机体T细胞免疫功能的影响 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2014年03期
页码:
218-221
栏目:
肿瘤介入
出版日期:
2014-03-25

文章信息/Info

Title:
 The influence of different micro?蛳 injury interventional treatments on the T lymphocyte immune function in patients with primary hepatocellular carcinoma
作者:
 韩聚强 范公忍 任永强 郭汉斌 李国安 夏长虹 王 帅 龚丽娟 曹建彪
Author(s):
 HAN Ju?蛳 qiang FAN Gong?蛳 ren REN Yong?蛳 qiang GUO Han?蛳 bin LI Guo?蛳 an XIA Chang?蛳 hong WANG Shuai GONG Li?蛳 juan CAO Jian?蛳 biao.
 Institute of Liver Disease, General Hospital of Beijing Military Region, Beijing 100700, China
关键词:
 【关键词】 肝细胞癌 肝动脉栓塞化疗术 射频消融治疗术 免疫功能
文献标志码:
A
摘要:
 【摘要】 目的 探讨微创介入治疗肝癌对机体T细胞免疫功能的影响。方法 肝动脉栓塞化疗(TACE)治疗肝癌31例,射频消融(RFA)治疗肝癌19例,根据肿瘤直径大小分为小肝癌组(直径 ≤ 5 cm)和大肝癌组(直径 > 5 cm)。分别于术前及术后1、7 d留置外周血,用流式细胞术检测CD3、CD4、CD8及 CD4/CD8比值的变化。结果 小肝癌组,TACE与RFA治疗术后1 d外周血T细胞亚群无明显变化,但术后7 d时,RFA治疗组外周血T细胞亚群 CD3、CD4、CD8及CD4/CD8比值较治疗前相比明显增高,而TACE组外周血T细胞亚群 CD4及CD4/CD8比值较治疗前明显下降。大肝癌组,无论TACE还是RFA治疗,术后1 d外周血T细胞亚群指标较治疗前明显下降(P < 0.05),而7 d后外周血T细胞亚群 CD3、CD4、CD8及CD4/CD8比值较治疗前显著增高,其中RFA组T细胞亚群较TACE组恢复更为显著。结论 不同微创治疗方式治疗肝癌后对机体T细胞免疫系统影响不同,与肿瘤大小密切相关。

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备注/Memo

备注/Memo:
 (收稿日期:2013-8-20)
更新日期/Last Update: