[1]周卫忠,刘 圣,杨正强,等.氰基丙烯酸酯胶栓塞原发性肝细胞癌合并重度肝动脉门静脉瘘12例疗效分析[J].介入放射学杂志,2013,(08):641-645.
 ZHOU Wei? zhong,LIU Sheng,YANG Zheng? qiang,et al. Transarterial embolization therapy with cyanoacrylate for severe arterioportal shunt associated with hepatocellular carcinoma[J].journal interventional radiology,2013,(08):641-645.
点击复制

氰基丙烯酸酯胶栓塞原发性肝细胞癌合并重度肝动脉门静脉瘘12例疗效分析 ()

PDF下载中关闭

分享到:

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2013年08期
页码:
641-645
栏目:
肿瘤介入
出版日期:
2013-08-30

文章信息/Info

Title:
 Transarterial embolization therapy with cyanoacrylate for severe arterioportal shunt associated with hepatocellular carcinoma
作者:
 周卫忠 刘 圣 杨正强 周春高 夏金国 赵林波 叶 伟 施海彬
Author(s):
 ZHOU Wei?蛳 zhong LIU Sheng YANG Zheng?蛳 qiang ZHOU Chun?蛳 gao XIA Jin?蛳 guo ZHAO Lin?蛳 bo YE Wei SHI Hai?蛳 bin.
 Department of Radiology, First Affiliated Hospital, Nanjing Medical University, Nanjing, China
关键词:
 【关键词】 癌肝细胞 动静脉瘘 栓塞治疗性 氰基丙烯酸酯
文献标志码:
A
摘要:
 【摘要】 目的 评价采用α-氰基丙烯酸正丁酯(N?蛳 butyl 2?蛳 cyanoacrylate,NBCA)胶栓塞治疗肝癌伴重度肝动脉门静脉瘘(arterioportal shunt,APS)的临床疗效。方法 2006年1月至2010年1月,采用NBCA胶栓塞治疗12例原发性肝细胞癌合并有门静脉主干表现为离肝血流的重度APS患者。随访和分析12例重度APS患者的手术前后APS改善情况、肿瘤反应、生存期和手术相关并发症等。结果 接受NBCA胶栓塞的12例患者在术后即刻造影显示APS迅速改善。而在进行随访复查造影的10例中,有8例的APS得到持续改善。按mRECIST标准在首次栓塞术后第4个月肿瘤取得最大疗效;接受随访的病例中部分缓解为2/10,疾病进展为3/10,疾病稳定为5/10。患者的半年、1年和2年的生存率分别为67%,33%,8%;中位生存期为275 d,介入栓塞未出现严重并发症。结论 采用NBCA胶栓塞肝癌合并重度APS患者是一种安全有效的治疗方法。

参考文献/References:

 [1] Llovet JM, Real MI, Monta?觡a X, et al. Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial[J]. Lancet, 2002, 359: 1734 ?蛳 1739.
[2] Lazaridis KN, Kamath PS. Images in hepatology. Arterio?蛳 portal fistula causing recurrent variceal bleeding[J]. J Hepatol, 1998, 29: 142.
[3] Velazquez RF, Rodriguez M, Navascues CA, et al. Prospective analysis of risk factors for hepatocellular carcinoma in patients with liver cirrhosis[J]. Hepatology, 2003, 37: 520 ?蛳 527.
[4] Ngan H, Peh WC. Arteriovenous shunting in hepatocellular carcinoma: its prevalence and clinical significance[J]. Clin Radiol, 1997, 52: 36 ?蛳 40.
[5] Clark RA, Frey RT, Colley DP, et al. Transcatheter emboliza?蛳 tion of hepatic arteriovenous fistulas for control of hemobilia[J]. Gastrointest Radiol, 1981, 6: 353 ?蛳 356.
[6] Furuse J, Iwasaki M, Yoshino M, et al. Hepatocellular carcinoma with portal vein tumor thrombus: embolization of arterioportal shunts[J]. Radiology, 1997, 204: 787 ?蛳 790.
[7] Guedin P, Gaillard S, Boulin A, et al. Therapeutic management of intracranial dural arteriovenous shunts with leptomeningeal venous drainage: report of 53 consecutive patients with emphasis on transarterial embolization with acrylic glue[J]. J Neurosurg, 2010, 112: 603 ?蛳 610.
[8] 李向东, 王伟中. α-氰丙烯酸正丁酯栓塞肝癌动静脉瘘的临床应用[J]. 中国医学影像技术, 2002, 18: 798 ?蛳 800.
[9] 刘 圣, 施海彬, 杨正强, 等. α-氰基丙烯酸正丁酯栓塞治疗肝细胞癌并肝动脉-门静脉瘘的临床价值[J]. 中华放射学杂志, 2009, 43: 279 ?蛳 283.
[10] Oken MM, Creech RH, Tormey DC, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group[J]. Am J Clin Oncol, 1982, 5: 649 ?蛳 655.
[11] Kim YJ, Lee HG, Park JM, et al. Polyvinyl alcohol embolization adjuvant to oily chemoembolization in advanced hepatocellular carcinoma with arterioportal shunts[J]. Korean J Radiol, 2007, 8: 311 ?蛳 319.
[12] Lencioni R, Llovet JM. Modified RECIST (mRECIST) assessment for hepatocellular carcinoma[J]. Semin Liver Dis, 2010, 30: 52 ?蛳 60.
[13] Shyr YM, Su CH, Chiang JH, et al. Angiographic arterio?蛳 venous shunt and venous thrombosis in the prognosis of hepatoma[J]. Zhonghua Yi Xue Za Zhi (Taipei), 1990, 45: 246 ?蛳 252.
[14] Huang MS, Lin Q, Jiang ZB, et al. Comparison of long?蛳 term effects between intra?蛳 arterially delivered ethanol and Gelfoam for the treatment of severe arterioportal shunt in patients with hepatocellular carcinoma[J]. World J Gastroenterol, 2004, 10: 825 ?蛳 829.
[15] 孙 磊, 施海彬, 刘 圣, 等. 肝细胞癌肝动脉门静脉分流形成的相关因素分析[J]. 介入放射学杂志, 2012, 21: 206 ?蛳 210.
[16] Murata S, Tajima H, Nakazawa K, et al. Initial experience of transcatheter arterial chemoembolization during portal vein occlusion for unresectable hepatocellular carcinoma with marked arterioportal shunts[J]. Eur Radiol, 2009, 19: 2016 ?蛳 2023.
[17] Izaki K, Sugimoto K, Sugimura K, et al. Transcatheter arterial embolization for advanced tumor thrombus with marked arterioportal or arteriovenous shunt complicating hepatocellular carcinoma[J]. Radiat Med, 2004, 22: 155 ?蛳 162.
[18] 诸葛宇征, 张建武, 陈 洪, 等. 原发性肝细胞癌合并肝动脉-门静脉瘘介入封堵治疗研究的临床疗效[J]. 中华肝脏病杂志, 2007, 15: 273 ?蛳 275.
[19] 罗鹏飞, 陈晓明, 张良明, 等. 肝癌合并动静脉瘘的处理方法探讨[J]. 中华放射学杂志, 2002, 36: 114 ?蛳 117.

相似文献/References:

[1]张 琳,黄学全,王健,等.自主研发电化学治疗同轴电极与传统针式电极电解效应的对比研究[J].介入放射学杂志,2012,(02):148.
 ZHANG Lin,HUANG Xue-quan,WANG Jian,et al.The electrolytic effect in electrochemotherapy: a comparative study between self-prepared coaxial electrode and conventional needle electrode[J].journal interventional radiology,2012,(08):148.
[2]赵 玮,王伟中,陈莹,等.耳部动静脉畸形供血动脉的血管造影研究[J].介入放射学杂志,2012,(02):103.
 ZHAO Wei,WANG Wei-zhong,CHEN Ying,et al.Angiographic findings of the feeding arteries of auricular arteriovenous malformations[J].journal interventional radiology,2012,(08):103.
[3]邹俊民,龙世娟,张振明. 改良髂内动脉化疗联合放疗治疗Ⅲ~Ⅳa期 子宫颈癌32例[J].介入放射学杂志,2012,(02):123.
 ZOU Jun-min,LONG Shi-Juan,ZHANG Zheng-ming..Improved internal iliac artery chemotherapy combined with radiotherapy for the treatment of stage Ⅲ-Ⅳa cervical cancers[J].journal interventional radiology,2012,(08):123.
[4]王昌明,李 选,宋世兵,等.肝门部胆道引流管折叠技术在肝移植后胆道非吻合口狭窄治疗中的应用[J].介入放射学杂志,2012,(02):136.
 WANG Chang-ming,LI Xuan,SONG Shi-bing,et al.The application of biliary catheter folding technique in the treatment of hilar nonanastomotic biliary strictures after orthotopic liver transplantation[J].journal interventional radiology,2012,(08):136.
[5]赵玉峰,孙玉琴,韩晓静,等. 输卵管介入再通术后受孕时机的研究[J].介入放射学杂志,2012,(02):158.
 ZHAO Yu-feng,SUN Yu-qin,HAN Xiao-jing,et al.The optimal time for conception after fallopian tube recanalization therapy[J].journal interventional radiology,2012,(08):158.
[6]含 笑,曹建民,史东宏,等.吉西他滨、顺铂动静脉联合化疗治疗晚期非小细胞肺癌的近期疗效分析[J].介入放射学杂志,2012,(02):119.
 HAN Xiao,CAO Jian-min,SHI Dong-hong,et al.Bronchial artery infusion of Gemcitabine and Cisplatin combined with systemic chemotherapy for advanced non-small cell lung cancer: its short-term efficacy[J].journal interventional radiology,2012,(08):119.
[7]姚雪松,李 槐.不可手术切除的肝细胞癌的疗效评价标准——改良RECIST标准更可靠[J].介入放射学杂志,2012,(03):177.
 . Therapeutic evaluation criterion of inoperable hepatocellular carcinomas: modified RECIST as a more reliable standard[J].journal interventional radiology,2012,(08):177.
[8]齐 立,李慎茂,俸军林,等. 动脉溶栓与机械碎栓联合动脉溶栓的对比分析[J].介入放射学杂志,2012,(03):180.
 ,,et al. Comparison of the therapeutic efficacy between simple arterial thrombolysis and mechanical thrombectomy combined with arterial thrombolysis for acute cerebral infarction at its ultraearly stage[J].journal interventional radiology,2012,(08):180.
[9]石 潆,赵 卫,沈 进,等.脑动静脉畸形栓塞治疗术并发颅内出血的原因及处理[J].介入放射学杂志,2012,(03):185.
 ,,et al.Intracranial hemorrhage due to embolization therapy for cerebral arteriovenous malformation: its causes and management [J].journal interventional radiology,2012,(08):185.
[10]周 慷,李晓光,金征宇,等.清宫术前子宫动脉化疗栓塞术治疗瘢痕妊娠的疗效分析[J].介入放射学杂志,2012,(03):190.
 ,,et al.Therapeutic analysis of bilateral uterine artery chemoembolization performed before uterine dilation and curettage for cesarean scar pregnancy [J].journal interventional radiology,2012,(08):190.
[11]万豪光,许 伟,徐 浩,等. 经导管化疗栓塞联合经皮微波消融治疗中晚期肝癌64例的预后分析[J].介入放射学杂志,2014,(06):477.
 WAN Hao- guang,XU Wei,XU Hao,et al. Transcatheter arterial chemoembolization combined with percutaneous microwave ablation for the treatment of intermediate- advanced hepatocellular carcinoma: analysis of prognostic factors in 64 cases[J].journal interventional radiology,2014,(08):477.

备注/Memo

备注/Memo:
 (收稿日期:2012-11-08)
更新日期/Last Update: