[1]陈红宇,李琦,陈庆华,等.丹参酮ⅡA-聚乳酸/羟基乙酸微球对兔肝动脉栓塞作用的研究[J].介入放射学杂志,2010,(12):977-981.
 CHEN Hong-yu,LI Qi,CHEN Qing-hua,et al.The embolization effect of tanshinoneⅡA-polylactic acid/glycolic acid microspheres on the hepatic artery in experimental rabbits[J].journal interventional radiology,2010,(12):977-981.
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丹参酮ⅡA-聚乳酸/羟基乙酸微球对兔肝动脉栓塞作用的研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2010年12期
页码:
977-981
栏目:
实验研究
出版日期:
2010-12-25

文章信息/Info

Title:
The embolization effect of tanshinoneⅡA-polylactic acid/glycolic acid microspheres on the hepatic artery in experimental rabbits
作者:
陈红宇李琦陈庆华赵泽华韩蕾王之徐嵩森王炎
200062  上海中医药大学附属普陀医院;上海中医药大学中西医结合肿瘤介入研究所;上海医药工业研究院
Author(s):
CHEN Hong-yu LI Qi CHEN Qing-hua ZHAO Ze-hua HAN Lei WANG Zhi XU Song-sen WANG Yan.
Laboratorial Center, Putuo Hospital to Affiliated, Shanghai University of Traditional Chinese Medicine; Institute of Interventional Oncology, Shanghai 200062, China
关键词:
丹参酮ⅡA 微球 聚乳酸/羟基乙酸 栓塞 介入
分类号:
R73-3
文献标志码:
摘要:
目的观察经肝动脉注入丹参酮ⅡA聚乳酸/羟基乙酸微球对兔肝动脉的栓塞作用。方法新西兰兔24只在DSA监视下经肝动脉注入丹参酮ⅡA微球,注入后10min,1、3、7、14、21、30、42d各取3只再次造影,观察肝动脉栓塞情况,并处死取肝、心、脾、肺、肾和胃组织,观察病理变化,同时作血常规和肝、肾功能检查。结果栓塞后10min造影显示,肝动脉末梢血管消失。栓塞后第1、3、7、14、21、30d造影,肝动脉末梢血管均未显影。栓塞后第42d造影显示肝动脉末梢血管已显影。病理切片显示栓塞部位出现炎性及坏死。常规和生化结果:介入栓塞后白细胞出现一过性升高,第7d恢复正常水平(P>0.05);AST、ALT均在栓塞后第3d达到最高值,第7d恢复正常水平(P>0.05)。结论丹参酮ⅡA微球具有良好的肝动脉末梢栓塞效果,栓塞时间在30~42d,是一种理想的肿瘤介入栓塞剂。

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备注/Memo

备注/Memo:
收稿日期:20100705
上海市重点学科资助项目(NO.S30302);上海市卫生局青年基金资助项目(NO.2009Y91)
更新日期/Last Update: 2010-12-25