[1]黄职妹,宁额尔敦巴格,李 慧,等.CT引导下人工腹水结合三维可视化系统辅助射频消治疗难消融复发性肝癌 [J].介入放射学杂志,2022,31(04):387-393.
 HUANG Zhimei,NING Eerdunbage,LI Hui,et al.CT-guided artificial ascites combined with three-dimensional visualization system-assisted radiofrequency ablation for refractory recurrent hepatocellular carcinoma[J].journal interventional radiology,2022,31(04):387-393.
点击复制

CT引导下人工腹水结合三维可视化系统辅助射频消治疗难消融复发性肝癌
()

PDF下载中关闭

分享到:

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
31
期数:
2022年04
页码:
387-393
栏目:
临床研究
出版日期:
2022-06-15

文章信息/Info

Title:
CT-guided artificial ascites combined with three-dimensional visualization system-assisted radiofrequency ablation for refractory recurrent hepatocellular carcinoma
作者:
黄职妹 宁额尔敦巴格 李 慧 马 榕 林青雨 郑舒淇 黄金华
Author(s):
HUANG Zhimei NING Eerdunbage LI Hui MA Rong LIN Qingyu ZHENG Shuqi HUANG Jinhua.
Department of Minimally-Invasive Intervention, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong Province 510060, China
关键词:
【关键词】 肝癌 射频消融 困难部位 人工腹水 三维可视化系统 技术成功率
文献标志码:
A
摘要:
【摘要】 目的 评价CT引导下人工腹水结合三维可视化系统(3DVAPS)辅助射频消融治疗难消融的复发性肝癌的临床疗效和安全性。方法 回顾性分析中山大学肿瘤防治中心2015年3月至2020年12月177例复发性肝细胞癌患者的CT引导下射频消融的资料,其中257个病灶位于有挑战性的消融困难部位。肿瘤预后包括消融相关并发症、人工腹水技术成功率、完全消融技术成功率。 结果 177例患者的腹腔注入0.9%氯化钠溶液100~3 000 mL,平均853.71 mL,其中169例(95.48%)成功诱导人工腹水。术后复查腹部CT可见腹腔注水全部消失,其中仅有94例(53.11%)术中出现轻微并发症,均未出现严重并发症。术后162例患者消融边缘充分,增强扫描示消融区无强化。CT引导下人工腹水结合3DVAPS辅助射频消融手术的完全消融技术成功率为91.53%(162/177)。 结论 CT引导下人工腹水结合3DVAPS辅助射频消融治疗难消融复发性肝癌是一种安全、有效的治疗方法。

参考文献/References:

[1] Wang H, Lu Z, Zhao X. Tumorigenesis, diagnosis, and therapeutic potential of exosomes in liver cancer[J]. J Hematol Oncol, 2019, 12: 133.
[2] Eggert T, Greten TF. Current standard and future perspectives in non- surgical therapy for hepatocellular carcinoma[J]. Digestion, 2017, 96: 1- 4.
[3] 陈付文,郑春生,黄柿兵,等. 肝动脉化疗栓塞联合射频消融治疗大肝癌的临床观察[J]. 介入放射学杂志, 2015, 24:684- 687.
[4] Kim DW, Talati C, Kim R. Hepatocellular carcinoma(HCC): beyond sorafenib- chemotherapy[J]. J Gastrointest Oncol, 2017,8:256- 265.
[5] Tan W, Deng Q, Lin S, et al. Comparison of microwave ablation and radiofrequency ablation for hepatocellular carcinoma: a systematic review and meta- analysis[J]. Int J Hyperthermia, 2019, 36: 264- 272.
[6] 刘会永,万象新,符 孔,等. CT引导下经皮微波消融术与腹腔镜手术治疗原发性肝癌的疗效比较[J]. 介入放射学杂志, 2019, 28:991- 995.
[7] Minami Y, Nishida N, Kudo M. Therapeutic response assessment of RFA for HCC: contrast- enhanced US, CT and MRI[J]. World J Gastroenterol, 2014, 20: 4160- 4166.
[8] Takai Takamatsu R, Okano A, Yamakawa G et al. Impact of an ultrasound- guided radiofrequency ablation training program on the outcomes in patients with hepatocellular carcinoma[J]. Diagn Interv Imaging, 2019, 100: 771- 780.
[9] Maeda M, Saeki I, Sakaida I, et al. Complications after radio- frequency ablation for hepatocellular carcinoma: a multicenter study involving 9,411 Japanese patients[J]. Liver Cancer, 2020, 9: 50- 62.
[10] 任 炜,杨 薇. 射频消融治疗复发性肝癌疗效及预后因素分析[J]. 介入放射学杂志, 2015, 24:923- 927.
[11] Orcutt ST, Anaya DA. Liver resection and surgical strategies for management of primary liver cancer[J]. Cancer Control, 2018, 25: 1073274817744621.
[12] Lu DS, Raman SS, Limanond P, et al. Influence of larze peritumoral vessels on outcome of radiofrequency ablation of liver tumors[J]. J Vasc Interv Radiol, 2003, 14: 1267- 1274.
[13] Wang Y, Zhang L, Li Y, et al. Computed tomography- guided percutaneous microwave ablation with artificial ascites for problematic hepatocellular tumors[J]. Int J Hyperthermia, 2020, 37: 256- 262.
[14] Rajyaguru DJ, Borgert AJ, Smith AL, et al. Radiofrequency ablation versus stereotactic body radiotherapy for localized hepatocellular carcinoma in nonsurgically managed patients: analysis of the National Cancer Database[J]. J Clin Oncol, 2018, 36: 600- 608.
[15] Kang TW, Lim HK, Cha DI. Aggressive tumor recurrence after radiofrequency ablation for hepatocellular carcinoma[J]. Clin Mol Hepatol, 2017, 23: 95- 101.
[16] Wang CC, Kao JH. Artificial ascites is feasible and effective for difficult- to- ablate hepatocellular carcinoma[J]. Hepatol Int, 2015, 9: 514- 519.
[17] Hakime A, Tselikas L, Otmezguine Y, et al. Artificial ascites for pain relief during microwave ablation of subcapsular liver tumors[J]. Cardiovasc Intervent Radiol, 2015, 38: 1557- 1562.
[18] Nam SY, Rhim H, Kang TW, et al. Percutaneous radiofrequency ablation for hepatic tumors abutting the diaphragm: clinical assessment of the heat- sink effect of artificial ascites[J]. AJR Am J Roentgenol, 2010, 194: W227- W231.
[19] 王竞立,赵 辉. 消融术治疗高危部位肝癌相关技术研究进展[J]. 介入放射学杂志, 2020, 29:431- 434.
[20] 刘德林,黄 斌,孙希希,等. 人工腹水辅助超声引导下经皮微波消融治疗邻近横膈肝癌的应用价值[J]. 中华医学超声杂志(电子版), 2020, 17:776- 781.
[21] Li X, An C, Liu FY, et al. The value of 3D visualization operative planning system in ultrasound- guided percutaneous microwave ablation for large hepatic hemangiomas: a clinical comparative study[J]. BMC Cancer, 2019, 19: 550.
[22] Huang ZM, Zuo MX, Gu YK, et al. Computed tomography- guided radiofrequency ablation combined with transarterial embolization assisted by a three- dimensional visualization ablation planning system for hepatocellular carcinoma in challenging locations: a preliminary study[J]. Abdom Radiol(NY), 2020, 45: 1181- 1192.
[23] Ikemoto T, Shimada M, Yamada S. Pathophysiology of recurrent hepatocellular carcinoma after radiofrequency ablation[J]. Hepatol Res, 2017, 47: 23- 30.
[24] Chinnaratha MA, Sathananthan D, Pateria P, et al. High local recurrence of early- stage hepatocellular carcinoma after percutaneous thermal ablation in routine clinical practice[J]. Eur J Gastroenterol Hepatol, 2015, 27: 349- 354.
[25] Komorizono Y, Oketani M, Sako K, et al. Risk factors for local recurrence of small hepatocellular carcinoma tumors after a single session, single application of percutaneous radiofrequency ablation[J]. Cancer, 2003, 97: 1253- 1262.
[26] Zhao Z, Wu J, Liu X, et al. Insufficient radiofrequency ablation promotes proliferation of residual hepatocellular carcinoma via autophagy[J]. Cancer Lett, 2018, 421: 73- 81.
[27] Chen J, Peng K, Hu D, et al. Tumor location influences oncologic outcomes of hepatocellular carcinoma patients undergoing radiofrequency ablation[J]. Cancers(Basel), 2018, 10: 378.
[28] Kang TW, Lim HK, Lee MW, et al. Perivascular versus nonperi- vascular small HCC treated with percutaneous RF ablation: retrospective comparison of long- term therapeutic outcomes[J]. Radiology, 2014, 270: 888- 899.
[29] Rhim H, Lim HK, Kim YS, et al. Percutaneous radiofrequency ablation with artificial ascites for hepatocellular carcinoma in the hepatic dome: initial experience[J]. AJR Am J Roentgenol, 2008, 190:91- 98.
[30] Hsieh YC, Limquiaco JL, Lin CC, et al. Radiofrequency ablation following artificial ascites and pleural effusion creation may improve outcomes for hepatocellular carcinoma in high- risk locations[J]. Abdom Radiol(NY), 2019, 44: 1141- 1151.
[31] Uehara T, Hirooka M, Ishida K, et al. Percutaneous ultrasound- guided radiofrequency ablation of hepatocellular carcinoma with artificially induced pleural effusion and ascites[J]. J Gastroenterol, 2007, 42: 306- 311.
[32] Adan ML, Olveira MA, Perez RJP, et al. Percutaneous radiofre- quency ablation with artificial ascites for hepatocellular carcinoma adjacent to the diaphragm[J]. Gastroenterol Hepatol, 2010, 33: 709- 715.
[33] Lee EJ, Rhim H, Lim HK, et al. Effect of artificial ascites on thermal injury to the diaphragm and stomach in radiofrequency ablation of the liver: experimental study with a porcine model[J]. AJR Am J Roentgenol, 2008, 190: 1659- 1664.
[34] Song I, Rhim H, Lim HK, et al. Percutaneous radiofrequency ablation of hepatocellular carcinoma abutting the diaphragm and gastrointestinal tracts with the use of artificial ascites: safety and technical efficacy in 143 patients[J]. Eur Radiol, 2009, 19: 2630- 2640.
[35] Kondo Y, Yoshida H, Shiina S, et al. Artificial ascites technique for percutaneous radiofrequency ablation of liver cancer adjacent to the gastrointestinal tract[J]. Br J Surg, 2006, 93: 1277- 1282.

相似文献/References:

[1]蒲红.上海市第二届射频消融疑难病例研讨会纪要[J].介入放射学杂志,1997,(01):63.
[2]蒲红,尹炯,王咏梅,等.显性间隔房室旁路的射频消融[J].介入放射学杂志,1997,(02):104.
[3]杨永波,程红岩.肝动脉化疗栓塞治疗中碘油用量的现状与研究进展[J].介入放射学杂志,2012,(04):348.
 .The volume of Lipiodol used in TACE: its current situation and research progress [J].journal interventional radiology,2012,(04):348.
[4]罗荣光,黄金华.肿瘤射频消融:电极的类型和消融灶的特点[J].介入放射学杂志,2011,(02):159.
 LUO Rong-guang,HUANG Jin-hua..Radiofrequency ablation of tumors: the relationship between the electrode type and the feature of ablated zone[J].journal interventional radiology,2011,(04):159.
[5]程洪涛,郭晨阳,黎海亮,等.TACE联合射频消融治疗原发性肝癌疗效的影响因素分析[J].介入放射学杂志,2012,(03):216.
 ,,et al.TACE combined with CTguided percutaneous radiofrequency ablation for the treatment of primary hepatocellular carcinomas: an analysis of factors affecting the therapeutic result [J].journal interventional radiology,2012,(04):216.
[6]姚红响,陈根生,诸葛英,等.肝动脉化疗栓塞联合CT引导射频消融序贯治疗中小肝癌的临床应用[J].介入放射学杂志,2012,(04):301.
 ,,et al.Sequential treatment with TACE and CTguided RFA for small and moderate sized HCC [J].journal interventional radiology,2012,(04):301.
[7]朱先海,吕维富,鲁 东,等.超选择性肾动脉栓塞术联合射频消融治疗肾癌的临床应用[J].介入放射学杂志,2011,(07):541.
 ZHU Xian-hai,LV Wei-fu,LU Dong,et al.Superselective renal artery embolization combined with radiofrequency ablation for the treatment of renal carcinomas: evaluation of clinical results[J].journal interventional radiology,2011,(04):541.
[8]谢小西,吕银祥,章宏欣,等. 肝动脉化疗栓塞、射频消融联合125Ⅰ粒子植入 治疗原发性肝癌的临床应用[J].介入放射学杂志,2011,(11):863.
 XIE Xiao-xi,LV Yin-xiang,ZHANG Hong-xin,et al.The clinical application of TACE together with RFA and 125Ⅰ seed implantation in treating hepatocellular carcinoma[J].journal interventional radiology,2011,(04):863.
[9]张   磊,陆骊工,李   勇,等.门静脉支架联合肝动脉化疗栓塞治疗肝癌伴门静脉癌栓的临床研究[J].介入放射学杂志,2011,(12):968.
 ZHANG Lei,LU Li-gong,LI Yong,et al.Portal vein stent placement combined with TACE for the treatment of hepatocellular carcinoma associated with tumor thrombus in portal vein[J].journal interventional radiology,2011,(04):968.
[10]李建军,郑加生,崔雄伟,等. 肝肿瘤CT引导经皮射频消融术后胆道并发症防治[J].介入放射学杂志,2011,(12):984.
 LI Jian-jun,ZHENG Jia-sheng,CUI Xiong-wei,et al.The prevention and treatment of biliary complications occurred after CT-guided percutaneous radiofrequency ablation for hepatic neoplasms[J].journal interventional radiology,2011,(04):984.
[11]帕哈尔丁·白克热,杨树法,黄伍奎,等.肝动脉化疗栓塞联合射频消融术治疗30例原发性大肝癌的疗效评价[J].介入放射学杂志,2012,(04):322.
 ,,et al.TACE combined with radiofrequency ablation for massive primary hepatocellular carcinomas: a clinical therapeutic evaluation [J].journal interventional radiology,2012,(04):322.
[12]彭国文,李晓群. 射频消融及组合方案治疗特殊/高危部位肝癌的中远期疗效[J].介入放射学杂志,2013,(06):525.
 PENG Guo? wen,LI Xiao? qun.. The mid?蛳 to?蛳 long term efficacy of radiofrequency ablation together with combination regimen for the treatment of hepatic carcinomas located at special or high?蛳 risk regions[J].journal interventional radiology,2013,(04):525.
[13]管清龙,任伟新,纪卫政.肝癌治疗后血清内血管内皮生长因子对预后影响的研究进展[J].介入放射学杂志,2013,(08):701.
 GUAN Qing? long,REN Wei? xin,JI Wei? zheng..The impact of serum vascular endothelial growth factor expression on the prognosis in patients with hepatocellular carcinoma after treatment: recent progress in clinical research[J].journal interventional radiology,2013,(04):701.
[14]陈付文,郑春生,黄柿兵,等.肝动脉化疗栓塞联合射频消融治疗大肝癌的临床观察[J].介入放射学杂志,2015,(08):684.
 CHEN Fu- wen,ZHENG Chun- sheng,HUANG Shi- bing,et al.TACE combined with RFA for the treatment of massive primary hepatocellular carcinomas: observation of clinical efficacy and safety[J].journal interventional radiology,2015,(04):684.
[15]付静静,王 凇,杨 薇.射频消融联合肝动脉化疗栓塞治疗肝癌的应用[J].介入放射学杂志,2016,(03):268.
 FU Jing- jing,WANG Song,YANG Wei.Clinical application of radiofrequency ablation combined with transcatheter arterial chemoembolization for the treatment of liver cancer [J].journal interventional radiology,2016,(04):268.
[16]任衍乔,郑传胜.肝癌射频消融术后各种影像学评价应用与进展 [J].介入放射学杂志,2018,27(10):993.
 REN Yanqiao,ZHENG Chuansheng..Different imaging assessments for hepatocellular carcinoma after radiofrequency ablation: clinical application and recent progress[J].journal interventional radiology,2018,27(04):993.

备注/Memo

备注/Memo:
(收稿日期:2021- 04- 05)
(本文编辑:李 欣)
更新日期/Last Update: 2022-05-11