[1]管清龙,任伟新,纪卫政.肝癌治疗后血清内血管内皮生长因子对预后影响的研究进展[J].介入放射学杂志,2013,(08):701-704.
 GUAN Qing? long,REN Wei? xin,JI Wei? zheng..The impact of serum vascular endothelial growth factor expression on the prognosis in patients with hepatocellular carcinoma after treatment: recent progress in clinical research[J].journal interventional radiology,2013,(08):701-704.
点击复制

肝癌治疗后血清内血管内皮生长因子对预后影响的研究进展 ()

PDF下载中关闭

分享到:

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2013年08期
页码:
701-704
栏目:
综述
出版日期:
2013-08-30

文章信息/Info

Title:
The impact of serum vascular endothelial growth factor expression on the prognosis in patients with hepatocellular carcinoma after treatment: recent progress in clinical research
作者:
 管清龙 任伟新 纪卫政
Author(s):
 GUAN Qing?蛳 long REN Wei?蛳 xin JI Wei?蛳 zheng.
Department of Interventional Radiology, the First Affiliated Hospital of Xinjiang Medical University, Wulumuqi 830054, China 
关键词:
【关键词】 肝癌 血管内皮生长因子 射频消融 肝动脉灌注化疗栓塞术 靶向治疗
文献标志码:
A
摘要:
 【摘要】 血管内皮生长因子诱导肿瘤血管形成,对肿瘤生长、侵袭和转移有重要作用。近年来,国内外学者研究认为肝癌治疗后血管内皮生长因子的表达与预后有重要关系。本文主要对肝癌行不同的治疗后血管内皮生长因子对预后的影响进行综述。

参考文献/References:

 [1] Zhu AX, Duda DG, Sahani DV, et al. HCC and angiogenesis: possible targets and future directions[J]. Nat Rev Clin Oncol, 2011, 8: 292 ?蛳 301.
[2] Shibuya M. Structure and function of VEGF/VEGF?蛳 receptor system involved in angiogenesis[J]. Cell Struct Funct, 2001, 26: 25 ?蛳 35.
[3] Kopfstein L, Veikkola T, Djonov VG, et al. Distinct roles of vascular endothelial growth factor?蛳 D in lymphangiogenesis and metastasis[J]. Am J Pathol, 2007, 170: 1348 ?蛳 1361.
[4] Poon RT, Lau CP, Cheung ST, et al. Quantitative correlation of serum levels and tumor expression of vascular endothelial growth factor in patients with hepatocellular carcinoma[J]. Cancer Res, 2003, 63: 3121 ?蛳 3126.
[5] Xiang ZL, Zeng ZC, Fan J, et al. Gene expression profiling of fixed tissues identified hypoxia?蛳 inducible factor?蛳 1α, VEGF, and matrix metalloproteinase?蛳 2 as biomarkers of lymph node metastasis in hepatocellular carcinoma[J]. Clin Cancer Res, 2011, 17: 5463 ?蛳 5472.
[6] Yu JX, Huang XF, Lv WM, et al. Combination of stromal?蛳 derived factor?蛳 1alpha and vascular endothelial growth factor gene?蛳 modified endothelial progenitor cells is more effective for ischemic neovascularization[J]. Vasc Surg, 2009, 50: 608 ?蛳 616.
[7] Li B, Sharpe EE, Maupin AB, et al. VEGF and PlGF promote adult vasculogenesis by enhancing EPC recruitment and vessel formation at the site of tumor neovascularization[J]. FASEB J, 2006, 20: 1495 ?蛳 1497.
[8] 钱中清, 曾耀英, 王 通, 等. VEGF诱导血管内皮细胞产生H2O2及其促增殖作用[J]. 中国病理生理杂志, 2007, 23: 533 ?蛳 535.
[9] Liu Z, Yan L, Xiang T, et al. Expression of vascular endothelial growth factor and matrix metalloproteinase?蛳 2 correlates with the invasion and metastasis of hepatocellular carcinoma[J]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2003, 20: 249 ?蛳 250.
[10] 夏红天, 郭广宏, 黄晓强, 等. HCC患者手术前后血管内皮细胞相关细胞因子的变化[J]. 中国肝胆外科杂志, 2011, 7: 554 ?蛳 557.
[11] Sun HC, Tang ZY. Angiogenesis in hepatocellular carcinoma: the retrospectives and perspectives[J]. J Cancer Res Clin Oncol, 2004, 130: 307 ?蛳 319.
[12] 罗祥基, 陈 汉, 吴孟超, 等. 原发性HCC术后肝内复发与肝外转移再手术切除疗效分[J]. 中国肿瘤学杂志, 2005, 14: 158 ?蛳 160.
[13] 龚时文, 区庆嘉. 裸鼠肝部分切除术后HCC血管内皮生长因子及微血管密度变化的研究[J]. 岭南现代临床外科, 2003, 3: 53 ?蛳 54.
[14] Mathonnet M, Descottes B, Valleix D, et al. Quantitative analysis using ELISA of vascular endothelial growth factor and basic fibroblast growth factor in human colorectal Cancer, liver metastasis of colorectal Cancer and hepatocellular carcinoma[J]. World J Gastroenterol, 2006, 12: 3782 ?蛳 3783.
[15]狄纪君, 郭卫东, 张惠洁, 等. TACE联合热疗治疗原发性HCC的临床观察[J]. 临床肿瘤学杂志, 2012, 17: 42 ?蛳 46.
[16] 任正刚, 林芷英, 叶胜龙, 等. 肝脏残留癌的动脉化疗栓塞及预后因素分析[J]. 中华肿瘤杂志, 2001, 23: 72 ?蛳 74.
[17] 徐 辉, 王 滨, 高志芹, 等. 肝动脉灌注化疗栓塞术后残癌组织血管内皮生长因子表达的研究[J]. 临床放射学杂志, 2004, 35: 1092 ?蛳 1095.
[18] Khan MR, Poon RK, Ng KK, et al. Comparison of percuta?蛳 neousand surgical approaches for radiofrequency ablation of small and medium[J]. Arch Surg, 2007, 142: 1136 ?蛳 1143.
[19] Benetti A, Berenzi A, Gambarotti M, et al. Transforming growth factor?蛳 beta1 and CD105 promote the migration of hepatocellular carcinoma?蛳 derived endothelium[J]. Cancer Res, 2008, 68: 8626 ?蛳 8634.
[20] Nijkamp MW, van der Bilt JD, de Bruijn MT, et al. Accelerated perinecrotic outgrowth of colorectal liver metastases following radiofrequency ablation is a hypoxia?蛳 driven phenomenon[J]. Ann Surg, 2009, 249: 814 ?蛳 823.
[21] Nijkamp MW, Hoogwater FJ, Steller EJ, et al. CD95 is a key mediator of invasion and accelerated outgrowth of mouse colorectal liver metastases following radiofrequency ablation[J]. J Hepatol, 2010, 53: 1069 ?蛳 1077.
[22]成建萍, 倪雪君, 周国雄, 等. 超声引导下射频消融治疗肝癌后VEGF和AFP的变化[J]. 交通医学, 2010, 24: 86 ?蛳 88.
[23] Hendriksen EM, Span PN, Schuuring J, et al. Angiogenesis, hypoxia and VEGF expression during tumour growth in a human xenograft tumour model[J]. Microvasc Res, 2009, 77: 96 ?蛳 103.
[24]丁雪梅, 柯 山, 高 君, 等. HCC射频消融术后残留癌的肿瘤血管生成作用[J]. 中国普通外科杂志, 2011, 26: 456 ?蛳 459.
[25]孙文兵, 柯 山. HCC射频消融术后残留癌细胞过快增长[J]. 中华肝胆外科杂志, 2009, 15: 311 ?蛳 313.
[26] Chan SL, Mo FK, Wong CS, et al. A study of circulating interleukin 10 in prognostication of unresectable hepatocellular carcinoma[J]. Cancer, 2012, 118: 3984 ?蛳 3992.
[27] Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma[J]. N Engl J Med, 2008, 359: 378 ?蛳 390.
[28] Tai WT, Cheng AL, Shiau CW, et al. Signal transducer and activator of transcription 3 is a major kinase?蛳 independent target of sorafenib in hepatocellular carcinoma[J]. J Hepatol, 2011, 55: 1041 ?蛳 1048.
[29] Cheng AL, Kang YK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia?蛳 Pacific region with advanced hepatocellular carcinoma: a phase Ⅲ randomised, double?蛳 blind, placebo?蛳 controlled trial[J]. Lancet Oncol, 2009, 10: 25 ?蛳 34.
[30] 董家鸿, 吕文平. 肝细胞癌治疗的理念与技术进展[J/CD]. 中华临床医师杂志: 电子版, 2008: 123 ?蛳 126.
[31]易述红, 陈规划, 陆敏强, 等. VEGF rnRNA在预测HCC肝移植术后肿瘤复发和转移中的应用价值[J]. 中国普外基础与临床杂志, 2006, 13: 560 ?蛳 563.
[32]蹇兆成, 孙业全, 王 滨, 等. 内皮抑素在兔VX2肝移植瘤介入治疗中的应用价值[J]. 介入放射学杂志, 2009, 18: 285 ?蛳 289.
[33] Shimizu H, Mitsuhashi N, Ohtsuka M, et al. Vascular endothelial growth factor and angiopoietins regulate sinusoidal regeneration and remodeling after partial hepatectomy in rats[J]. World J Gastroenterol, 2005, 11: 7254 ?蛳 7260.
[34] Guo JH, Zhu X, Li XT, et al. Impact of serum vascular endothelial growth factor on prognosis in patients with unresectable hepatocellular carcinoma after transarterial chemoembolization[J]. Chin J Cancer Res, 2012, 24: 36 ?蛳 43. 

相似文献/References:

[1]杨永波,程红岩.肝动脉化疗栓塞治疗中碘油用量的现状与研究进展[J].介入放射学杂志,2012,(04):348.
 .The volume of Lipiodol used in TACE: its current situation and research progress [J].journal interventional radiology,2012,(08):348.
[2]李彩霞,冯 艳,谷 涛,等.p53介入治疗对VX2兔肝癌侵袭转移特性的影响[J].介入放射学杂志,2010,(10):800.
 LI Cai-xia,FENG Yan,GU Tao,et al.Effect of interventional treatment with p53 on the invasion and metastasis of VX2 liver tumor in experimental rabbits[J].journal interventional radiology,2010,(08):800.
[3]张培蕾,鲁海涛,朱悦奇,等.丁苯酞对大鼠局灶性脑缺血再灌注损伤的保护作用[J].介入放射学杂志,2012,(03):239.
 ,,et al.The protective effect of dl3nbutylphthalide on local cerebral ischemiareperfusion injury in experimental rats [J].journal interventional radiology,2012,(08):239.
[4]帕哈尔丁·白克热,杨树法,黄伍奎,等.肝动脉化疗栓塞联合射频消融术治疗30例原发性大肝癌的疗效评价[J].介入放射学杂志,2012,(04):322.
 ,,et al.TACE combined with radiofrequency ablation for massive primary hepatocellular carcinomas: a clinical therapeutic evaluation [J].journal interventional radiology,2012,(08):322.
[5]沈海洋,刘瑞宝,刘 岩,等. 肝右叶前、后段原发性肝癌TACE后VEGF及CD34的表达水平 ;[J].介入放射学杂志,2012,(06):469.
 SHEN Hai- yang,LIU Rui- bao,LIU Yan,et al. The expression levels of vascular endothelial growth factor and CD34 in residual cancerous tissues of primary hepatocellular carcinoma located at anterior and posterior segments of right lobe liver after TACE[J].journal interventional radiology,2012,(08):469.
[6]张   磊,陆骊工,李   勇,等.门静脉支架联合肝动脉化疗栓塞治疗肝癌伴门静脉癌栓的临床研究[J].介入放射学杂志,2011,(12):968.
 ZHANG Lei,LU Li-gong,LI Yong,et al.Portal vein stent placement combined with TACE for the treatment of hepatocellular carcinoma associated with tumor thrombus in portal vein[J].journal interventional radiology,2011,(08):968.
[7]敖 劲,张跃伟,徐 克. 明胶海绵微粒经动脉栓塞治疗原发性肝癌的研究现状[J].介入放射学杂志,2011,(12):1010.
 AO Jin,ZHANG Yue-wei,XU Ke..Gelatin sponge particle used as an embolic agent in transcatheter arterial chemoembolization treatment for primary hepatocellular carcinoma: its current situation in research[J].journal interventional radiology,2011,(08):1010.
[8]杜丹丹,吕维富. 肝癌射频消融后的影像学评价[J].介入放射学杂志,2012,(01):75.
 DU Dan dan,Lv Wei fu..Imaging evaluation of liver cancer after radiofrequency ablation therapy[J].journal interventional radiology,2012,(08):75.
[9]赵 艳,韩国宏,白 苇,等. 药物缓释微球肝动脉化疗栓塞治疗肝癌研究进展[J].介入放射学杂志,2012,(01):78.
 ZHAO Yan,HAN Guo-hong,BAI Wei,et al.Transarterial chemoembolization with drug-eluting beads for hepatocellular carcinoma: its research progress[J].journal interventional radiology,2012,(08):78.
[10]何海涛,刘 圣,刘建秦,等. 肝癌TACE术并发脑碘油栓塞二例并文献复习[J].介入放射学杂志,2012,(08):682.
 HE Hai- tao,LIU sheng,LIU Jian- qing,et al. Cerebral Lipiodol embolism occurred after transcatheter arterial chemoembolization for hepatocellular carcinoma: report of two cases with literature review[J].journal interventional radiology,2012,(08):682.
[11]管清龙,纪卫政,任伟新,等.肝癌介入治疗后血清缺氧诱导因子和血管内皮生长因子含量变化对预后的影响[J].介入放射学杂志,2014,(02):142.
 GUAN Qing? long,JI Wei? zheng,REN Wei? xin,et al.The influence of serum HIF?蛳 1a and VEGF content on the prognosis in patients with hepatocellular carcinoma after TACE[J].journal interventional radiology,2014,(08):142.

备注/Memo

备注/Memo:
 (收稿日期:2013-03-23)
更新日期/Last Update: