[1]陈付文,郑春生,黄柿兵,等.肝动脉化疗栓塞联合射频消融治疗大肝癌的临床观察[J].介入放射学杂志,2015,(08):684-687.
 CHEN Fu- wen,ZHENG Chun- sheng,HUANG Shi- bing,et al.TACE combined with RFA for the treatment of massive primary hepatocellular carcinomas: observation of clinical efficacy and safety[J].journal interventional radiology,2015,(08):684-687.
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肝动脉化疗栓塞联合射频消融治疗大肝癌的临床观察 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年08期
页码:
684-687
栏目:
肿瘤介入
出版日期:
2015-08-25

文章信息/Info

Title:
TACE combined with RFA for the treatment of massive primary hepatocellular carcinomas: observation of clinical efficacy and safety
作者:
陈付文 郑春生 黄柿兵 杨龙林 刘建平 施长生
Author(s):
CHEN Fu- wen ZHENG Chun- sheng HUANG Shi- bing YANG Long- lin LIU Jian- ping SHI Chang- sheng
Interventional Ward, Department of Medical Imaging, Anqing Municipal Petrochemical Hospital, Anqing, Anhui province 246000, China
关键词:
【关键词】 肝癌 肝动脉化疗栓塞 射频消融 介入
文献标志码:
A
摘要:
【摘要】 目的 探讨肝动脉化疗栓塞(TACE)联合射频消融(RFA)治疗大肝癌的疗效及安全性。方法 分析2011年3月—2014年6月23例大肝癌患者先行TACE治疗1~2次,再序贯RFA治疗,并随访其术后临床症状、甲胎蛋白(AFP)、肝功能及影像学改变情况等。结果 23例患者治疗后临床症状均有缓解,一般状况改善;所有患者AFP均明显下降,差异有统计学意义(t=2.48,P=0.002);影像检查见病灶体积有所缩小,病灶内有不同程度的碘油沉积,并可见片状坏死区,增强后无明显强化;显效、有效、无效率分别为43.5%、52.2%、4.3%。随访4~22个月,中位生存时间为9.6个月,半年和1年的生存率分别为86.9%和43.4%。结论 TACE联合RFA治疗大肝癌疗效确切,值得临床推广应用。

参考文献/References:

[参 考 文 献]

[1] 常中飞, 王茂强, 刘凤永, 等. 综合治疗巨大肝癌的临床疗效及预后因素分析[J]. 中华肿瘤杂志, 2014, 36: 59- 62.
[2] 代向党, 王 赢, 程 喆, 等. 肝动脉化疗栓塞联合射频消融治疗中晚期肝癌的临床疗效分析[J]. 放射学实践, 2010, 25: 799- 802.
[3] Miyayama S, Matsui O, Taki K, et al. Extrahepatic blood supply to hepatocellular carcinoma: angiographic demonstration and transcatheter arterial chemoembolization[J]. Cardiovasc Intervent Radiol, 2006, 29: 39- 48.
[4] 李金鹏, 陈 华, 石丛丛, 等. TACE联合射频消融与单独射频消融治疗结节型肝癌临床对比分析[J]. 临床放射学杂志,2013, 32: 1159- 1163.
[5] Kelogrigoris M, Laspas F, Kyrkou K, et al. Percutaneous radiofrequency ablation for malignant liver tumours in challenging locations[J]. J Med Imaging Radiat Oncol, 2012, 56: 48- 54.
[6] 陈长广, 倪才方, 陈 珑. 肝动脉栓塞联合射频消融对兔肝癌模型细胞凋亡的影响[J]. 实用放射学杂志, 2014, 30: 156- 159.
[7] Garmi L, Georgiades C. Combination percutaneous and intra-arterial therapy for the treatment of hepatocellular carcinoma: a review[J]. Semin Intervent Radiol, 2010, 27: 296- 301.
[8] 吴宇旋, 窦永充, 张彦舫, 等. 经皮射频消融治疗巨大肝癌[J]. 介入放射学杂志, 2007, 16: 755- 758.
[9] 帕哈尔丁?白克热, 杨树法, 黄伍奎, 等. 肝动脉化疗栓塞联合射频消融术治疗30例原发性大肝癌的疗效评价[J]. 介入放射学杂志, 2012, 21: 322- 326.
[10] 彭国文, 李晓群. 射频消融及组合方案治疗特殊/高危部位肝癌的中远期疗效[J]. 介入放射学杂志, 2013, 22: 525- 528.

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备注/Memo

备注/Memo:
(收稿日期:2014-11-27)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2015-08-23