[1]梁刚柱,张福先,刘 勇. 辛伐他汀对兔股动脉球囊损伤后内膜增生和平滑肌细胞增殖的影响[J].介入放射学杂志,2014,(01):50-53.
　LIANG Gang? zhu,ZHANG Fu? xian,LIU Yong.. The effects of simvastatin on intimal hyperplasia and vascular smooth muscle cell proliferation of balloon?蛳 injured femoral artery in experimental rabbits[J].J Intervent Med,2014,(01):50-53.
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 辛伐他汀对兔股动脉球囊损伤后内膜增生和平滑肌细胞增殖的影响 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2014年01期
页码:
50-53
栏目:
实验研究
出版日期:
2014-01-20

文章信息/Info

Title:
 The effects of simvastatin on intimal hyperplasia and vascular smooth muscle cell proliferation of balloon?蛳 injured femoral artery in experimental rabbits
作者:
 梁刚柱;  张福先;  刘 勇
Author(s):
LIANG Gang?蛳 zhu;  ZHANG Fu?蛳 xian;  LIU Yong.
 Department of Vascular Surgery， Beijing Shijitan Hospital， Capital Medical University， Beijing 100038， China
关键词:
 ; 【关键词】 股动脉;  球囊损伤;  辛伐他汀;  动物实验
文献标志码:
A
摘要:
 【摘要】 目的 评价辛伐他汀对兔股动脉球囊损伤后血管狭窄和平滑肌细胞增殖的影响。方法 将24只雄性新西兰兔随机分为假手术组、动脉狭窄模型组和辛伐他汀组，每组8只。除假手术组外，其余两组行股动脉球囊损伤，辛伐他汀组给予辛伐他汀灌胃干预。术后第14天处死实验兔，取出血管标本，处理后行HE染色观察组织病理变化。计算机病理图像分析系统测量动脉管腔、内弹力层、外弹力层围绕面积，计算内膜、中膜面积和内膜/中膜面积比值，免疫组化法检测动脉壁增殖细胞核抗原（PCNA）表达，观察平滑肌细胞增殖情况。结果 与动脉狭窄模型组相比，辛伐他汀组血管管腔面积增加，但差异无统计学意义（P = 0.057），新生内膜面积显著减少（P = 0.006），内膜/中膜面积比值降低，但差异无统计学意义（P = 0.16），血管壁PCNA的阳性表达指数显著降低（P = 0.003）。结论 辛伐他汀可以显著抑制兔股动脉球囊损伤后内膜增生和平滑肌细胞增殖。

参考文献/References:

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 （收稿日期：２０１3-０7-０2）
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