[1]马占龙,滕皋军,麦筱莉,等.血管内皮祖细胞局部移植防治血管内皮损伤后再狭窄形成的实验研究[J].介入放射学杂志,2007,(02):95-98.
　MA Zhan-long,TENG Gao-jun,MAI Xiao-li,et al.Local transplantation of endothelial progenitor cells to reduce restenosis after angioplasty in rabbit model[J].journal interventional radiology,2007,(02):95-98.
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血管内皮祖细胞局部移植防治血管内皮损伤后再狭窄形成的实验研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2007年02期
页码:
95-98
栏目:
实验研究
出版日期:
2007-02-15

文章信息/Info

Title:
Local transplantation of endothelial progenitor cells to reduce restenosis after angioplasty in rabbit model
作者:
马占龙; 滕皋军; 麦筱莉; 等
210009  南京 东南大学附属中大医院放射科分子影像实验室
Author(s):
MA Zhan-long; TENG Gao-jun; MAI Xiao-li; JU Sheng-hong; SUN Jun-hui; CHEN Jun; ZHANG Hong-ying; SHI Hong-jian; YU Hui; LI Guo-zhao
Molecular Imaging Laboratory，Department of Radiology，Zhong-Da Hospital，Southeast University，Nanjing２１０００９，China
关键词:
血管内皮祖细胞; 再狭窄; 细胞移植; 兔
分类号:
R５４３.３
文献标志码:
A
摘要:
目的探讨血管内皮祖细胞（EPC）局部移植防治血管成形术后再狭窄形成的可行性。方法分离、鉴定并培养新西兰大白兔外周血（EPC），用２．５F球囊扩张并损伤兔右侧颈动脉血管内皮，对损伤血管进行局部EPC移植。共作细胞移植兔１３只，其中３只移植荧光标记EPC；对照组８只，局部灌注生理盐水。细胞移植后４d，对２只荧光标记细胞移植兔取移植细胞后受损伤血管行病理组织学检查，其余实验兔４周后对损伤血管行病理组织学检查。结果荧光标记细胞移植后４d，病理学检测显示损伤血管内皮有强荧光表达；４周后，细胞移植组血管壁轻度增厚，对照组血管壁增厚明显，血管腔明显狭窄。两组间血管壁厚度差异有统计学意义（P＜０．０１）。结论介入法局部移植同种异体血管内皮祖细胞可防治血管成形术后再狭窄的形成。

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期：２００６-１１-２９
基金项目：东南大学优秀博士学位论文基金（２００７２０）作者单位：２１０００９南京东南大学附属中大医院放射科分子影像实验室
更新日期/Last Update: 2007-02-15