[1]池嘉昌,沈加林,许建荣,等.全肝CT灌注成像在原发性肝癌TACE术后局部病灶活性评估中的临床应用[J].介入放射学杂志,2010,(07):540.
 CHI Jiachang,SHEN Jialin,XU Jianrong,et al.Clinical application of whole-liver perfusion-enhanced CT imaging in evaluating the activity of residual hepatocellular carcinoma after TACE[J].journal interventional radiology,2010,(07):540.
点击复制

全肝CT灌注成像在原发性肝癌TACE术后局部病灶活性评估中的临床应用()

PDF下载中关闭

分享到:

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2010年07期
页码:
540
栏目:
肿瘤介入
出版日期:
2010-07-15

文章信息/Info

Title:
Clinical application of whole-liver perfusion-enhanced CT imaging in evaluating the activity of residual hepatocellular carcinoma after TACE
作者:
池嘉昌沈加林许建荣
200127上海交通大学医学院附属仁济医院放射科
Author(s):
CHI Jia-changSHEN Jia-linXU Jian-rongTANG Rui CHENG Jie-jun.
Renji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai200127,China
关键词:
肝细胞癌CT灌注成像技术栓塞
分类号:
R
文献标志码:
A
摘要:
目的探讨全肝灌注CT增强扫描检查在肝癌TACE术后局部病灶活性评估中的作用。方法38例行TACE治疗的肝癌患者,术后6周在Siemens128排CT上行全肝灌注CT增强扫描和DSA造影。根据全肝灌注扫描图像获得肝脏灌注参数,与DSA造影结果进行对比,以DSA造影作为标准,分别分析CT灌注对TACE术后局部肿瘤活性的显示情况。结果全肝CT灌注共检出病灶42处(100%),诊断正确率88.09%,灵敏度94.11%,特异度62.50%,阳性预测值=91.42%;阴性预测值=71.42%;一致性检验Kappa值0.8613。TACE术后局部肿瘤生长区的相关灌注参数与非瘤区肝组织的灌注参数,两者的血流量(BF)、血容量(BV)、肝动脉指数(HAI )和肝门脉灌注(PVP)差异均有统计学意义(P<0.01)。结论全肝灌注CT增强扫描能很好的显示肝癌TACE术后局部病灶的活性,在肝癌TACE术后评估中具有较高的应用价值。

参考文献/References:

[1]Zhang JS.TACE combined with other treatment for primary hepatic carcinoma :current status and the role of interventional radiologist[J].China J Interv Imaging Ther,2008,5:83-852.
[2]贾雨辰,程红岩,陈栋,等.原发性肝癌的介入治疗[J].肝胆外科杂志,1998,6:316-318.
[3]Zhou ZF,Huang HL,Xu B,et al.Clinic application with MSCT perfusion in liver tumor[J].Linchuang Fangshexue Zazhi ,2006,25:233-237.
[4]黄光明,祖茂衡.CT灌注成像在肝癌TACE术后评估中的应用[J].中国介入影像与治疗学,2009,6:63-66.
[5]Tsushima Y,Unno Y,Koizumi J,et al.Hepatic perfusion changes after transcatheter arterial embolization(TAE)of hepatocellular carcinoma :measurement by dynamic computed tomography(CT)[J].Dig Dis Sci,1998,43:317-322.
[6]梁文,唐海亮,全显跃,等.64层螺旋CT全肝灌注模式成像在肝细胞癌中的初步应用[J].Chin J Med Imaging Technol,2007,23:707-709.
[7]郑加贺,郭启勇,卢再呜,等.CT灌注成像评价肝细胞癌TACE前后血供的初步经脸[J].中国医学影像学杂志,2007,15:5-8.
[8]赵立峰,徐克,苏洪英,等.CT灌注诊断原发性肝癌TACE术后局部肿瘤生长的研究[J].现代肿瘤医学,2009,17:79-82.
[9]裴小青,李安华,韩峰,等.超声造影成像对TACE综合治疗肝癌疗效的评判价值与螺旋CT对比分析[J].中国超声医学杂志,2005,21:764-766.
[10]商健彪,李彦豪,刘方颖,等.18F2FDG PET、碘油沉积形式及血清AFP在肝细胞癌介入治疗后疗效评价中的关系[J].介入放射学杂志,2004,13:421-424.
[11]尚全良,肖恩华,贺忠,等.肝癌经导管动脉灌注化疗栓塞术疗效的MR扩散加权成像动态研究[J].中华放射学杂志,2006,140:235-240.
[12]Liang Zhong,Wen-Jing Wang,Jian-Rong Xu.Clinical appli-cation of hepatic CT perfusion[J].World J Gastroenterol,2009,28;15:907-911.
[13]陈昆涛,何健垣,郭瑞珍,等.肝癌化疗栓塞前后CT灌注特征与肿瘤血管生成相关性的实验研究[J].Chin Clin Med Imaging,2007,18:591-593.
[14]史芳,李凌.VEGF在肝癌TACE联合抗血管治疗及预后中的作用[J].江西医学院学报,2009,49:133-138.
[15]肖亦明,杨建勇,江利,等.肝动脉栓塞术后肝脏血流动力学改变的CT灌注成像[J].广东医药,2006,27:798-799.
[16]Kan Z,Kobayashi S,Phongkitkarun S,et al.Functional CT quantification of tumor perfusion after transhepatic arterial embolization in a rat model[J].Radiology,2005,237:144-150.

相似文献/References:

[1]张绪敬,程佩芳,董光,等.原发性肝癌经导管化疗、栓塞前后血中凝血酶原变化的研究[J].介入放射学杂志,1992,(01):33.
[2]欧阳墉,马和平,张学军,等.肝细胞癌的鉴别诊断——附10例分析[J].介入放射学杂志,1996,(01):40.
[3]王悍 王精兵 张贵祥 王麟川.肝细胞癌动脉化疗栓塞术后并发脑梗死一例[J].介入放射学杂志,2005,(04):442.
 WANG Han WANG Jing-bing ZHANG Gui-xiang WANG Lin-chuan.Cerebral infarction aften transaterial shemoembolization for hepatocellular carcinoma a cage report[J].journal interventional radiology,2005,(07):442.
[4]周斌,李征然,钱结胜,等.原发性肝癌肝移植后肿瘤复发的化疗栓塞治疗[J].介入放射学杂志,2009,(03):185.
 ZHOU Bin,LI Zhengran,QIAN Jiesheng,et al.Chemoembolization for recurrent hepatocellular carcinoma after liver transplantation[J].journal interventional radiology,2009,(07):185.
[5]黄渊全,贾中芝,冯耀良,等.CT灌注成像在肝癌TACE术后疗效评价中的应用价值[J].介入放射学杂志,2009,(06):437.
 HUANG Yuan-quan,JIA Zhong-zhi,FENG Yao-liang,et al.Clinical application of CT perfusion imaging in estimating the efficacy of transcatheter arterial chemoembolization for the treatment of hepatocellular carcinoma[J].journal interventional radiology,2009,(07):437.
[6]郭丽萍,张晓玲,王莉娜.经导管肝动脉化疗栓塞联合高强度聚焦超声治疗原发性肝癌的护理[J].介入放射学杂志,2010,(04):328.
 GUO Liping,ZHANG Xiaoling,WANG Lina.The nursing care for patients of hepatocellular carcinoma treated with transcatheter hepatic arterial chemoembolization and high intensive focus ultrasound[J].journal interventional radiology,2010,(07):328.
[7]沈海洋,杨光,刘瑞宝,等.肝右叶前、后段原发性肝癌动脉化疗栓塞术后近期疗效比较[J].介入放射学杂志,2010,(05):382.
 SHEN Haiyang,YANG Guang,LIU Ruibao,et al.Short-term effects of TACE for primary hepatocellular carcinoma of the right hepatic lobe:a comparison between the lesions in anterior segments and the lesions in posterior segments[J].journal interventional radiology,2010,(07):382.
[8]翁志成,杨维竹,江娜,等.CT引导下125I放射性粒子植入治疗肝癌门静脉癌栓的疗效评价[J].介入放射学杂志,2010,(07):535.
 WENG Zhicheng,YANG Weizhu,JIANG Na,et al.Evaluation of CT-guided125I seed implantation combined with transcatheter arterial chemoem-bolization in treating portal vein tumor thrombus associated with hepatocellular carcinoma[J].journal interventional radiology,2010,(07):535.
[9]王惠文,刘瑞宝,刘   岩,等.原发性肝癌TACE后FAK、NFκBp65表达及意义[J].介入放射学杂志,2011,(08):621.
 WANG Hui-wen,LIU Rui-bao,LIU Yan,et al.The expression and significance of FAK and NF-κBp65 in hepatocellular carcinoma after transcatheter arterial chemoembolization[J].journal interventional radiology,2011,(07):621.
[10]姚雪松,闫 东,曾辉英,等.经动脉化疗栓塞治疗肝细胞癌疗效评估中C臂CT技术应用[J].介入放射学杂志,2014,(07):588.
 YAO Xue- song,YAN Dong,ZENG Hui- ying,et al.The application of C- arm CT imaging technique in evaluating the efficacy of TACE for hepatocellular carcinoma[J].journal interventional radiology,2014,(07):588.

备注/Memo

备注/Memo:
收稿日期:2009-11-24
基金项目:上海市重点学科建设项目资助(编号:S30203)及上海交通大学医学院重点学科
更新日期/Last Update: 2010-07-15