[1]王耀普,杨康健,赵思源,等.兔肝癌模型的改良接种及其DSA影像分析[J].介入放射学杂志,2010,(03):214.
　WANG Yaopu,YANG Kangjian,ZHAO Siyuan,et al.The modified inoculation method for the preparation of rabbit VX２hepatic carcinoma model and DSA imagining observation[J].journal interventional radiology,2010,(03):214.
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兔肝癌模型的改良接种及其DSA影像分析()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2010年03期
页码:
214
栏目:
实验研究
出版日期:
2010-03-15

文章信息/Info

Title:
The modified inoculation method for the preparation of rabbit VX２hepatic carcinoma model and DSA imagining observation
作者:
王耀普; 杨康健; 赵思源; 等
０４４０００山西省运城市中心医院导管室（王耀普）；第四军医大学唐都医院介入放射科（杨康健、赵思源、赵斌羽、曹玮、李超、杨清峰、王执民、张洪新）
Author(s):
WANG Yao－pu; YANG Kang－jian; ZHAO Si－yuan; ZHAO Bin－yu; CAO Wei; LI Chao; YANG Qing－feng; WANG Zhi－min; ZHANG Hong－xin．
Tangdu Hospital，Fourth Military Medical University of Chinese PLA，Xi ’an，Shaanxi Province７１００３８，China
关键词:
肝癌; 兔Vx２细胞株; 数字减影成像
分类号:
R７３５.７
文献标志码:
B
摘要:
目的建立可供实验研究稳定的兔Vx２移植性肝癌模型，探讨不同植瘤方式的成功率，并分析该肿瘤的DSA影像特征。方法６０只新西兰白兔随机分３组，每组２０只。将Vx２瘤细胞（５×１０ ７ 个）经肝动脉或经肝包膜分别接种于２组兔的肝左叶，建立对照肝癌模型。第３组经肝包膜植入瘤组织块（约含１０ ６ ～１０ ８ 个瘤细胞）建立改良肝癌模型。观察：①不同组植瘤的成活率。②改良Vx２移植性肝癌的DSA影像特征。结果３组植瘤成活率分别为７／２０、１０／２０、１９／２０，改良组植瘤成活率最高，差异有统计学意义（P＜０．０５）。DSA影像示该移植性肝癌具有丰富的血供。结论成功建立了兔Vx２移植性肝癌改良模型，瘤组织块种植方式成功率明显高于动脉途径和细胞液注射方式，为肝癌介入治疗的基础及临床研究提供了成熟的大型实验动物模型。

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备注/Memo

备注/Memo:
收稿日期：２０１０－０２－２５
更新日期/Last Update: 2010-03-15