[1]陆一峰,王 祁,何忠明.构建基于控制营养状况评分的列线图预测肝细胞癌TACE治疗患者预后[J].介入放射学杂志,2023,32(12):1190-1196.
　LU Yifeng,WANG Qi,HE Zhongming..Construction of a nomogram based on controlling nutritional status score for predicting the prognosis of hepatocellular carcinoma patients after receiving TACE[J].journal interventional radiology,2023,32(12):1190-1196.
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构建基于控制营养状况评分的列线图预测肝细胞癌TACE治疗患者预后()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
32
期数:
2023年12
页码:
1190-1196
栏目:
肿瘤介入
出版日期:
2024-01-02

文章信息/Info

Title:
Construction of a nomogram based on controlling nutritional status score for predicting the prognosis of hepatocellular carcinoma patients after receiving TACE
作者:
陆一峰;  王 祁;  何忠明
Author(s):
LU Yifeng;  WANG Qi;  HE Zhongming.
Department of Interventional Radiology， Third Affiliated Hospital of Soochow University （Changzhou Municipal First People’s Hospital）， Changzhou， Jiangsu Province 213000， China
关键词:
【关键词】 肝细胞癌;  经导管动脉化疗栓塞术;  控制营养状况评分;  列线图;  预后预测
文献标志码:
A
摘要:
【摘要】 目的 探讨控制营养状况（CONUT）评分对经导管动脉化疗栓塞术（TACE）治疗肝细胞癌（HCC）患者的预后意义，并构建整合多种预后因素的列线图模型，以帮助临床医师准确预测个体预后。方法 回顾性分析2017年1月至2020年6月于苏州大学附属第三医院接受TACE治疗的155例原发性HCC患者临床资料。通过受试者工作特征曲线（ROC）分析CONUT评分最佳截断值，Kaplan-Meier曲线分析其预后意义。采用单变量、多变量Cox生存分析确定接受TACE治疗HCC患者独立预后因素。以多变量分析的显著变量构建列线图模型，使用一致性指数（C-index）评价其预测TACE治疗HCC患者总生存期（OS）能力。绘制校准曲线评价预测概率与实际OS结局间的一致性。结果 CONUT评分预测OS最佳截断值为4，AUC值为0.766（95%CI=0.691～0.841）。高CONUT评分（≥4）组患者肿瘤直径更大（P=0.014），血清AFP水平更高（P=0.002），肝储备功能（P＜0.01）和TACE治疗反应（P＜0.01）更差，中位OS更短（P＜0.01）。Child-Pugh分级、肿瘤最大直径、血清AFP水平、BCLC分期、TACE治疗反应及CONUT评分（均P＜0.05）是TACE治疗后HCC患者OS的独立预测因素。基于以上变量构建列线图模型，其C-index为0.785（95%CI=0.691～0.879）。校准曲线显示模型预测概率与实际概率间具有高度一致性。结论 CONUT评分是评价接受TACE治疗HCC患者预后的简单可行工具。基于肿瘤生物学特征、TACE治疗反应及CONUT评分的列线图模型对HCC患者具有可靠的预后预测能力，值得进一步推广验证。

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备注/Memo

备注/Memo:
（收稿日期：2023- 04- 14）
（本文编辑：谷 珂）
更新日期/Last Update: 2024-01-02