[1]梁茂全,苏洪英. 肝癌化疗栓塞前后甲胎蛋白变化模式的临床意义[J].介入放射学杂志,2012,(04):333-338.
 .The transformation pattern of serum аfetoprotein after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma: its clinical significance [J].journal interventional radiology,2012,(04):333-338.
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 肝癌化疗栓塞前后甲胎蛋白变化模式的临床意义 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2012年04期
页码:
333-338
栏目:
临床研究
出版日期:
2012-04-28

文章信息/Info

Title:
The transformation pattern of serum аfetoprotein after transcatheter arterial chemoembolization in patients with hepatocellular carcinoma: its clinical significance  
作者:
 梁茂全 苏洪英
Author(s):
 LIANG Maoquan SU Hongying     
 Department of Radiology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China
关键词:
 【关键词】 肝细胞癌 甲胎蛋白 化疗栓塞 疗效
文献标志码:
A
摘要:
 【摘要】 目的 评价经导管动脉化疗栓塞前后血清甲胎蛋白(AFP)变化模式对原发性肝细胞癌(PHC)疗效的价值。 方法 回顾性分析2007年1月至2009年12月间符合纳入标准的127例PHC患者,所有病例均接受规律的经导管动脉化疗栓塞(TACE)治疗,然后将治疗前后血清AFP值的变化情况划分成转阴、下降、不变及上升等4种变化模式,并把纳入病例分成相应的A、B、C和D 4组,最后对各组进行疗效和生存等统计学分析。 结果 全部病例总缓解率19.7%;无进展率为71.7%;中位生存时间为18个月,3、6个月,1、2、和3年生存率分别为92.9%、84.3%、63.0%、22.8%和7.1%;A与B组, A与 C组,A与 D组,B与C组,B与 D组的组间比较差异具有统计学意义(P < 0.05)。一般体力状态和门静脉癌栓为影响PHC患者生存期的独立危险因素。 结论 血清AFP变化模式对PHC TACE后的疗效具有临床指导作用,转阴或下降模式的生存期与不变或上升模式相比,明显延长。

参考文献/References:

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(收稿日期:20111015)
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