[1]周承凯,梁惠民,李欣,等.实验兔VX2肝肿瘤模型制作及动脉插管技术探讨[J].介入放射学杂志,2006,(02):101-104.
　ZHOU Cheng-kai,LIANG Hui-ming,LI Xin,et al.Establishment of rabbit model bearing VX2 liver tumor experimentation and discussion of the selective hepatic arterial catheterization.[J].journal interventional radiology,2006,(02):101-104.
点击复制

实验兔VX2肝肿瘤模型制作及动脉插管技术探讨()

PDF下载中关闭

分享到：

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2006年02期
页码:
101-104
栏目:
实验研究
出版日期:
2006-02-01

文章信息/Info

Title:
Establishment of rabbit model bearing VX2 liver tumor experimentation and discussion of the selective hepatic arterial catheterization.
作者:
周承凯;  梁惠民;  李欣;  柳曦
430022,武汉,华中科技大学同济医学院附属协和医院放射科
Author(s):
ZHOU Cheng-kai; LIANG Hui-ming; LI Xin; et al
关键词:
肝癌;  动物模型;  介入治疗
分类号:
R73.36
摘要:
目的介绍应用VX2细胞株制作兔移植性肝癌模型,并探讨插管技术的应用.方法实验对象为新西兰大白兔(n=80),VX2瘤块组织接种于肝脏,接种后2～3周实验组(n=51)行剖腹直视下肝动脉直接楔入插管,并作DSA造影.对照组1和2(各10只)分别采取经股动脉-肝动脉插管和开腹经胃十二指肠动脉逆行插管方法对比研究.结果实验组插管成功率为98%(50/51),其中88%(45/51)完成超选择栓塞;对照组1和2的插管成功率分别为30%和40%,只有0/10和4/10完成超选择栓塞.结论移植性兔VX2肝癌是介入治疗实验研究较为理想的动物模型，综合影像评价有利于实验动物的筛选。采用肝动脉细针直接穿刺楔入法插管成功率高，可完成超选择栓塞，是值得推广的实验方法。

参考文献/References:

[1] Burgener H Peripheral hepatic artery embolization in rabbits with VX2 carcinoma of the liver[J] Cancer ，1980,46:56
[2] Miao Y.Ni Y.Bosmans H Radiofrequency ablation for eradication of renal tumor in a rabbit model by using a cooled-tip electrode technique[J] .Ann Surg Oncol，2001,8:651-657

相似文献/References:

[1]曹海利,孟巍,白彬.肝癌基因治疗研究新进展[J].介入放射学杂志,2008,(05):375.
　CAO Haili,MENG Wei,BAI Bin.New progress in research of gene therapy for hepatocellular carcinoma[J].journal interventional radiology,2008,(02):375.
[2]陆骊工,胡宝山,李勇,等.中晚期原发性肝癌合并症的介入治疗研究[J].介入放射学杂志,2008,(07):514.
　LU Ligong,HU Baoshan,LI Yong,et al.Study of interventional therapy for complications in advanced primary hepatocellular carcinoma[J].journal interventional radiology,2008,(02):514.
[3]杨伟洪,刘鹏程,梁珊瑚,等.多层螺旋CT血管造影在判断肝癌寄生供血中的价值[J].介入放射学杂志,2008,(09):654.
　YANG Weihong,LIU Pengchen g,LIANG Shanhu,et al.Evaluation of MSCTA for parasitic blood supply in hepatic carcinoma[J].journal interventional radiology,2008,(02):654.
[4]张茵,周兵,许秀芳,等.肝动脉化疗栓塞治疗原发性肝癌存活２０年一例[J].介入放射学杂志,2008,(09):684.
　ZHANG Yin,ZHOU Bing,XU Xiufang,et al.Survival more than２０years after transarterial chemical embolization for hepatocellular carcinoma：A case report[J].journal interventional radiology,2008,(02):684.
[5]官泳松,贺庆.肝癌介入治疗中应用p５３的几个要点[J].介入放射学杂志,2008,(11):761.
　GUAN Yongsong,HE Qing.Essentials in clinical application of p５３for tumors intervention－example of liver cancer[J].journal interventional radiology,2008,(02):761.
[6]肖运平,肖恩华.介入治疗在防治肝癌术后复发中的作用及进展[J].介入放射学杂志,2008,(11):831.
　XIAO Yunping,XIAO Enhua.The role and progress of interventional therapy in the prevention and treatment of postoperative hepatocellular carcinoma recurrence[J].journal interventional radiology,2008,(02):831.
[7]史震山,陈自谦,杨熙章,等.原发性大肝癌患者TACE后S－腺苷蛋氨酸的护肝作用[J].介入放射学杂志,2008,(11):790.
　SHI Zhenshan,CHEN Ziqian,YANG Xizhang,et al.The clinical study on the liver－protection of S－adenosy－methionine in large hepatocellular carcinoma patients after TACE[J].journal interventional radiology,2008,(02):790.
[8]王耀普,杨康健,赵思源,等.兔肝癌模型的改良接种及其DSA影像分析[J].介入放射学杂志,2010,(03):214.
　WANG Yaopu,YANG Kangjian,ZHAO Siyuan,et al.The modified inoculation method for the preparation of rabbit VX２hepatic carcinoma model and DSA imagining observation[J].journal interventional radiology,2010,(02):214.
[9]贺洪德,贺晶,罗中华,等.肝动脉化疗栓塞联合门静脉栓塞治疗中晚期肝癌的疗效评价[J].介入放射学杂志,2010,(03):191.
　HE Hongde,HE Jing,LUO Zhonghua,et al.Evaluation of the therapeutic effect of hepatic arterial chemoembolization combined with portal chemoembolization for advanced hepatic carcinomas[J].journal interventional radiology,2010,(02):191.
[10]李广琪,曹玮,李超,等.肝动脉热灌注对兔肝VX２肿瘤及正常肝组织血管渗透性功能的作用[J].介入放射学杂志,2010,(03):217.
　LI Guangqi,CAO Wei,LI Chao,et al.Influence of hepatic artery thermotherapy on the vascular permeability of hepatic tumor tissue and normal liver tissue in VX２tumor－bearing rabbits[J].journal interventional radiology,2010,(02):217.

备注/Memo

备注/Memo:
（收稿日期：2004-11-09）
更新日期/Last Update: 2010-11-19