[1]尚鸣异,张岩,高晓龙,等.多烯紫杉醇对人胆管癌细胞和胰腺癌细胞增殖和凋亡的影响[J].介入放射学杂志,2010,(01):46.
　SHANG Mingyi,ZHANG Yan,GAO Xiaolong,et al.The effect of docetaxel on the proliferation and apoptosis of human cholangiocarcinoma cell line and pancreatic cancer cell line[J].journal interventional radiology,2010,(01):46.
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多烯紫杉醇对人胆管癌细胞和胰腺癌细胞增殖和凋亡的影响()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2010年01期
页码:
46
栏目:
实验研究
出版日期:
2010-01-15

文章信息/Info

Title:
The effect of docetaxel on the proliferation and apoptosis of human cholangiocarcinoma cell line and pancreatic cancer cell line
作者:
尚鸣异; 张岩; 高晓龙; 唐俊军; 席芊; 黄宗良; 胡美玉; 王培军
２０００６５上海同济大学附属同济医院放射科（尚鸣异、张岩、高晓龙、唐俊军、席芊、黄宗良）；复旦大学附属中山医院中心实验室（胡美玉）
Author(s):
SHANG Ming－yi; ZHANG Yan; GAO Xiao－long; TANG Jun－jun; XI Qian; HUANG Zong－liang; HU Mei－yu; WANG Pei－jun．
Tongji Hospital，Tongji University，Shanghai２０００６５，China
关键词:
胰腺癌; 胆管细胞癌; 多烯紫杉醇; 增殖; 凋亡
分类号:
R７３５.８；R７３５.９
文献标志码:
B
摘要:
目的评价多烯紫杉醇对人胆管癌细胞HCCC－９８１０和胰腺癌细胞BXPC－３的增殖和凋亡影响，为药物涂层支架治疗恶性梗阻性黄疸的应用提供实验基础。方法应用四硝基偶氮唑蓝法测定紫杉醇对人胆管癌细胞HCCC－９８１０和胰腺癌细胞BXPC－３增殖的抑制作用，Hoechst染色法检测诱导细胞凋亡。结果多烯紫杉醇可明显抑制２种肿瘤细胞株的增殖，且该抑制效应随药物剂量的增加和作用时间的延长而增强（HCCC：χ ２ ＝２４．４２，P＜０．０１；BXPC－３：χ ２ ＝２４．６８，P＜０．０１），根据增殖曲线和统计学分析，选取０．４mg ／L为多烯紫杉醇最适实验浓度。凋亡分析实验显示多烯紫杉醇可诱导２种肿瘤细胞株的凋亡（HCCC：χ ２ ＝３０．０５，P＜０．０１；BXPC－３：χ ２ ＝２５．２２，P＜０．０１）。结论多烯紫杉醇有抑制BXPC－３和HCCC－９８１０的增殖并诱导肿瘤细胞凋亡的作用。

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期：２００９－０９－２５
更新日期/Last Update: 2010-01-15