[1]徐红豆,周卫忠,刘圣,等.经皮胆道支架联合125I粒子条腔内植入治疗恶性梗阻性黄疸的疗效分析[J].介入放射学杂志,2020,29(01):83-88.
　XU Hongdou,ZHOU Weizhong,LIU Sheng,et al.Percutaneous biliary stenting combined with intraluminal implantation of 125I seed strand for malignant obstructive jaundice: analysis of curative effect[J].journal interventional radiology,2020,29(01):83-88.
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经皮胆道支架联合125I粒子条腔内植入治疗恶性梗阻性黄疸的疗效分析()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
29
期数:
2020年01
页码:
83-88
栏目:
临床研究
出版日期:
2020-02-10

文章信息/Info

Title:
Percutaneous biliary stenting combined with intraluminal implantation of 125I seed strand for malignant obstructive jaundice: analysis of curative effect
作者:
徐红豆;  周卫忠 ; 刘圣; 周春高; 夏金国; 张卫; 施海彬
Author(s):
XU Hongdou;  ZHOU Weizhong;  LIU Sheng;  ZHOU Chungao;  XIA Jinguo;  ZHANG Wei;  SHI Haibin.
Department of Interventional Radiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jangsu Province 210029, China
关键词:
【关键词】　恶性梗阻性黄疸; 碘-125粒子;  裸支架;  支架通畅时间; 生存期
文献标志码:
A
摘要:
【摘要】　目的?评估经皮胆道植入支架联合125I粒子条在治疗恶性梗阻性黄疸中的安全性、有效性及临床应用价值。方法?回顾性分析2015年11月至2018年2月在收治的142例恶性梗阻性黄疸患者，其中50例患者（实验组）接受裸支架联合125I粒子条植入，92例患者（对照组）仅进行了裸支架的植入。观察两组患者支架通畅率、生存期及术后并发症。结果?实验组支架通畅期中位数为226 d，生存期中位数为194 d，对照组支架通畅期中位数为86 d，生存期中位数为117 d，实验组优于对照组（P＜0.05）。在实验组中，平均15颗125I粒子（8～22）作为粒子条联合裸支架同时植入胆管内。与手术前的实验室指标相比，两组术后1周肝功能包括总胆红素，直接胆红素，丙氨酸转氨酶显著降低，且两组间术后1周肝功能变化无统计学差异（P＞0.05），严重并发症仅发生在对照组的1例患者。结论?金属支架联合125I粒子条植入对恶性梗阻性黄疸的治疗有效、安全，可以提高支架通畅时间和患者生存期，值得进一步临床研究。

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备注/Memo

备注/Memo:
（收稿日期：2019-01-23）
（本文编辑：俞瑞纲）
更新日期/Last Update: 2020-02-08