[1]曹玮,吴发伟,刘毅勇,等.高强度聚焦超声对中晚期肝癌患者机体免疫细胞及其活性的影响[J].介入放射学杂志,2009,(04):308.
　CAO Wei,WU Fawei,LIU Yiyong,et al.The effect of high intensity focused ultrasound on the immunocyte and its activity in patients with advanced hepatic carcinoma[J].journal interventional radiology,2009,(04):308.
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高强度聚焦超声对中晚期肝癌患者机体免疫细胞及其活性的影响()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2009年04期
页码:
308
栏目:
临床研究
出版日期:
2009-04-15

文章信息/Info

Title:
The effect of high intensity focused ultrasound on the immunocyte and its activity in patients with advanced hepatic carcinoma
作者:
曹玮; 吴发伟; 刘毅勇; 等
７１００３８西安第四军医大学唐都医院介入科（曹玮、刘毅勇、齐连君、张洪新）；解放军第３２３医院肿瘤科（吴发伟）；第四军医大学卫生统计学教研室（万毅）
Author(s):
CAO Wei; WU Fa－wei; LIU Yi－yong; WAN Yi ; QI Lian－jun; ZHANG Hong－xin．
Department of Interventional Radiology，Tangdu Hospital，No．４Military Medical University，Xi ’an７１００３８，China
关键词:
肝癌; 高强度聚焦超声; T细胞亚群; NK细胞; NK细胞杀伤活性; 可溶性白细胞介素－２受体
分类号:
R３７５.７
文献标志码:
B
摘要:
目的观察高强度聚焦超声（HIFU）对中晚期肝癌患者的机体免疫细胞及其活性的影响。方法HCC患者３０例，经全身麻醉、超声肿瘤定位进行HIFU治疗，采用流式细胞仪及双抗体夹心法检测治疗前、后外周血T细胞亚群（CD３ ＋ 、CD４ ＋ 、CD８ ＋ ）、NK细胞的百分率及sIL－２R的变化。采用LDH释放法检测NK细胞的杀伤活性。结果HIFU治疗后CD３ ＋ 、NK细胞的百分率明显升高（P＜０．０５），NK细胞杀伤活性也升高（P＜０．０５），而CD８ ＋ 细胞的百分率及sIL－２R的水平明显降低（P＜０．０５）。结论HIFU具有激活机体免疫细胞活性作用，可使机体的免疫功能得到一定程度的改善。

参考文献/References:

［１］伍烽，陈文直，白晋，等．高强度聚焦超声治疗原发性肝癌的初步临床研究［J］．中华超声影像学杂志，１９９９，８：２１３－２１６．
［２］汪东文，马庆久，杜锡林，等．集束电极射频治疗肝癌患者后红细胞免疫功能和血清IL－２含量的变化［J］．中国现代医学杂志，２００４，l４：６７－６９．
［３］苏永杰，董家鸿，李海林，等．TissueLink与钳夹法在肝癌切除术中的应用比较［J］．中国现代普通外科进展，２００８，１１：７－９．
［４］Luo W，Zhou X，Zhang J，et al

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备注/Memo

备注/Memo:
收稿日期：２００８－１１－１７
更新日期/Last Update: 2009-04-15