[1]陈肖肖,马 赫,祖茂衡,等.细胞间黏附分子-3多态性和血浆浓度与国人布-加综合征关系研究[J].介入放射学杂志,2019,28(04):319-323.
 CHEN Xiaoxiao,MA He,ZU Maoheng,et al.Study on the relationship of intercellular adhesion molecule- 3 polymorphism and its plasma concentration with the occurrence of Budd- Chiari syndrome in Chinese[J].journal interventional radiology,2019,28(04):319-323.
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细胞间黏附分子-3多态性和血浆浓度与国人布-加综合征关系研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
28
期数:
2019年04期
页码:
319-323
栏目:
血管介入
出版日期:
2019-04-25

文章信息/Info

Title:
Study on the relationship of intercellular adhesion molecule- 3 polymorphism and its plasma concentration with the occurrence of Budd- Chiari syndrome in Chinese
作者:
陈肖肖 马 赫 祖茂衡 陆召军
Author(s):
CHEN Xiaoxiao MA He ZU Maoheng LU Zhaojun.
Department of Epidemiology and Health Statistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu Province 221004, China
关键词:
【关键词】 布-加综合征 病例对照研究 细胞间黏附分子- 3
文献标志码:
A
摘要:
【摘要】 目的 探讨国人布-加综合征(BCS)发病机制与细胞间黏附分子(ICAM)- 3基因单核苷酸多态性(SNP)位点rs117942573基因型分布和ICAM- 3血浆浓度的关系。方法 收集纳入2011年1月至2015年1月徐州医科大学附属医院确诊为原发性BCS患者300例(BCS组),同期纳入体检中心体检的健康人300例(对照组)。采用自制问卷对纳入对象进行面对面流行病学调查,收集BCS患者病案信息。采用试剂盒提取全血基因组DNA,竞争性等位基因特异性聚合酶链反应(KASP)检测rs117942573基因型。采用酶联免疫吸附试验(ELISA)检测血浆中ICAM- 3。结果 BCS组、对照组基因型分布差异有统计学意义(χ2=4.754,P=0.029)。BCS组血浆ICAM- 3浓度中位值为875.99 pg/mL(P25=648.87 pg/mL,P75=1 435.22 pg/mL),高于对照组(中位数为601.81 pg/mL,P25=502.89 pg/mL,P75=888.90 pg/mL),差异有显著统计学意义(Z=-7.342,P<0.001)。结论 BCS组与对照组ICAM- 3基因型分布及血浆浓度存在显著性差异,提示rs117942573可增加BCS风险,ICAM- 3表达增加可能与BCS肝脏损害有关。

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备注/Memo

备注/Memo:
(收稿日期:2018-06-21)
(本文编辑:边 佶)
更新日期/Last Update: 2019-04-09