[1]王丹,祖茂衡,魏宁,等.碘离子调控血管内皮细胞迁移机制研究[J].介入放射学杂志,2016,(06):524-528.
 WANG Dan,ZU Mao-heng,WEI Ning,et al.The role of iodine ions in regulating the migration of vascular endothelial cells [J].journal interventional radiology,2016,(06):524-528.
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碘离子调控血管内皮细胞迁移机制研究 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2016年06期
页码:
524-528
栏目:
实验研究
出版日期:
2016-06-25

文章信息/Info

Title:
The role of iodine ions in regulating the migration of vascular endothelial cells
作者:
王丹祖茂衡魏宁胡琳方林
Author(s):
WANG Dan ZU Mao-heng WEI Ning HU Lin FANG Lin
Department of Interventional Radiology, Affiliated Hospital of Xuzhou Medical College, Xuzhou, Jiangsu Province 221002, China
关键词:
【关键词】Budd-Chiari综合征 碘离子 血管内皮细胞 细胞迁移
文献标志码:
A
摘要:
【摘要】目的研究碘离子(I-)对血管内皮细胞(VEC)迁移及细胞分裂周期蛋白42(Cdc42)表达的影响,探讨细胞迁移与Budd-Chiari综合征隔膜形成机制。 方法将体外培养的VEC分为空白对照组和不同I-浓度实验组,用Transwell法检测各组细胞迁移数、I-与Cdc42抑制剂ML141作用后VEC迁移情况。采用Western blot技术检测不同I-浓度培养环境中Cdc42表达。 结果一定浓度的I-可以促进VEC迁移(P<0.05);ML141可抑制VEC迁移;100 μg/L I-组、300 μg/L I-组、500 μg/L I-组VEC Cdc42相对表达量高于其它各组(P<0.05)。 结论碘能促进VEC迁移,该效应可能与调整Cdc42表达有关。

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备注/Memo

备注/Memo:
(收稿日期:2015-08-12)


(本文编辑:边佶)
更新日期/Last Update: 2016-06-21