[1]李 征,米登海,杨克虎,等.经动脉化疗栓塞联合微波消融治疗肝癌有效性和安全性的系统评价[J].介入放射学杂志,2015,(11):957-963.
 LI Zheng,MI Deng- hai,YANG Ke- hu,et al.Effectiveness and safety of TACE combined with MWA for primary hepatic cancer: a systematic review[J].journal interventional radiology,2015,(11):957-963.
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经动脉化疗栓塞联合微波消融治疗肝癌有效性和安全性的系统评价 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年11期
页码:
957-963
栏目:
肿瘤介入
出版日期:
2015-11-25

文章信息/Info

Title:
Effectiveness and safety of TACE combined with MWA for primary hepatic cancer: a systematic review
作者:
李 征 米登海 杨克虎 曹 农 田金徽 马 彬 拜争刚
Author(s):
LI Zheng MI Deng- hai YANG Ke- hu CAO Nong TIAN Jin- hui MA Bin BAI Zheng- gang
First Clinical Medical College of Lanzhou University, Lanzhou, Gansu Province 730000, China
关键词:
【关键词】 肝癌 微波消融 经导管动脉化疗栓塞术 系统评价 Meta分析 随机对照试验
文献标志码:
A
摘要:
【摘要】 目的 评价经导管动脉化疗栓塞术(TACE)联合微波消融(MWA)治疗原发性肝癌的有效性及安全性,为临床实践与研究提供参考。方法 计算机检索Cochrane Library、PubMed、EMbase、Web of Science、CBM、CNKI、WanFang及VIP 8个数据库,同时辅以其他检索,收集所有TACE联合MWA治疗原发性肝癌的随机对照试验(RCT)。评价员按照研究计划书进行文献筛选和资料提取,并对纳入文献进行质量评价后,使用RevMan 5.3软件进行Meta分析。结果 共纳入19篇RCT(1 356例患者)。Meta分析结果显示:①联合组0.5年、1年、1.5年、2年和3年的总生存率均明显好于TACE组,且其差异均有统计学意义(P<0.05);合并结果分别为0.5年[RR=1.24,95%CI=(1.12,1.37)],1年[RR=1.50,95%CI=(1.38,1.62)],1.5年[RR=2.05,95%CI=(1.38,3.06)],2年[RR=1.97,95%CI=(1.65,2.36)],3年[RR=3.39, 95%CI=(2.32,4.96)]。②联合组的完全缓解率、总有效率、完全坏死率和甲胎蛋白(AFP)的转阴率均高于单独TACE组,联合组的复发率低于单独TACE组,且其差异均有统计学意义(P<0.05);合并结果分别为完全缓解率[RR=2.53,95%CI=(1.45,4.41)],总有效率[RR=1.69, 95%CI=(1.43,1.99)],完全坏死率[RR=2.51,95%CI=(1.87,3.36)],AFP转阴率[RR=1.49, 95%CI=(1.28,1.73)],复发率[RR=0.28, 95%CI=(0.15,0.52)]。结论 相比较单用TACE治疗,TACE联合MWA治疗原发性肝癌能提高患者近期疗效和远期生存率,降低复发率,且安全性仍较好。

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备注/Memo

备注/Memo:
(收稿日期:2015-03-03)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2015-11-24