[1]刘长富,郭 志,邢文阁,等.栓塞联合冷冻消融对比索拉菲尼治疗Ⅲ期肾癌疗效评价[J].介入放射学杂志,2015,(11):964-968.
 LIU Chang-fu,GUO Zhi,XING Wen-ge,et al.Efficacy comparison for the treatment of stage Ⅲ renal cell carcinoma: transcatheter renal arterial embolization combined with cryoablation vs. sorafenib[J].journal interventional radiology,2015,(11):964-968.
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栓塞联合冷冻消融对比索拉菲尼治疗Ⅲ期肾癌疗效评价 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年11期
页码:
964-968
栏目:
肿瘤介入
出版日期:
2015-11-25

文章信息/Info

Title:
Efficacy comparison for the treatment of stage Ⅲ renal cell carcinoma: transcatheter renal arterial embolization combined with cryoablation vs. sorafenib
作者:
 刘长富 郭 志 邢文阁 刘 方 司同国 杨雪玲
Author(s):
LIU Chang-fu GUO Zhi XING Wen-ge LIU Fang SI Tong-guo YANG Xue-ling
Department of Interventional Tumor Treatment, Cancer Hospital of Tianjin Medical University, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin City, Tianjin 300060, China
关键词:
【关键词】 肾癌 冷冻消融 栓塞 介入 索拉菲尼
文献标志码:
A
摘要:
【摘要】 目的 对比选择性肾动脉栓塞(TRAE)联合冷冻消融与索拉菲尼治疗Ⅲ期肾癌的临床疗效。方法 回顾性分析2008年1月至2012年1月61例不适合或拒绝外科手术的Ⅲ期肾癌患者临床资料,依据接受治疗情况分为两组:(1)TRAE联合冷冻消融治疗组33例,在TRAE治疗后2~3周,接受冷冻消融治疗。(2)单纯口服索拉菲尼组28例。肿瘤最大径(3.8~11.2) cm,平均(5.3±2.2) cm,总计68个瘤灶。患者术后随访行影像学(CT或MRI或B超)检查,观察治疗前后患者ECOG评分、肿瘤变化、转移淋巴结变化和生存预后。结果 随访时间(8~38)个月,平均19.3个月。治疗前两组患者的性别、年龄、病灶大小、ECOG评分差异无统计学意义。联合治疗组客观有效率(PR、CR)66.7%,疾病控制率(PR、CR、SD)93.9%,索拉菲尼组分别为21.4%、85.7%,两组比较,差异有统计学意义(P<0.05)。联合治疗组中位无进展生存期(mPFS)23个月、中位总生存期(mOS)35个月;索拉菲尼组分别为mPFS 19个月、mOS 34个月,联合治疗组mPFS较索拉菲尼组明显延长,差异有统计学意义(P<0.05),mOS联合组较索拉菲尼组略有延长但差异无统计学意义(P>0.05)。治疗后两组转移淋巴结变化差异不具有统计学意义(P>0.05)。联合治疗组和索拉菲尼组临床症状缓解率分别为92.9%(13/14)、80.0%(8/10)差异有统计学意义(P<0.05)。两组患者治疗前后肾功能变化及ECOG评分未见明显改变,差异无统计学意义(P>0.05)。结论 TRAE联合冷冻消融治疗Ⅲ期肾癌可以有效改善临床症状,提高肿瘤客观有效率和疾病控制率,延长mPFS及mOS,是不能手术Ⅲ期肾癌切实有效的方法之一。

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备注/Memo

备注/Memo:
(收稿日期:2015-05-26)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2015-11-24