[1]占美晓,李 勇,胡宝山,等.甲胎蛋白阴性肝癌射频消融治疗前血清中转移相关miRNA的临床价值[J].介入放射学杂志,2014,(07):601-605.
 ZHAN Mei- xiao,LI Yong,HU Bao- shan,et al.The clinical significance of the expression level of metastasis- related microRNA in the serum in AFP- negative hepatocellular carcinoma patients before radiofrequency ablation[J].journal interventional radiology,2014,(07):601-605.
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甲胎蛋白阴性肝癌射频消融治疗前血清中转移相关miRNA的临床价值()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2014年07期
页码:
601-605
栏目:
非血管介入
出版日期:
2014-07-25

文章信息/Info

Title:
The clinical significance of the expression level of metastasis- related microRNA in the serum in AFP- negative hepatocellular carcinoma patients before radiofrequency ablation
作者:
占美晓 李 勇 胡宝山 何 旭 黄建文 陆骊工
Author(s):
ZHAN Mei- xiao LI Yong HU Bao- shan HE Xu HUANG Jian- wen LU Li- gong.
Department of Interventional Radiology, Cancer Center, Guangdong Provincial Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province 510080, China
关键词:
肝肿瘤 微小RNA 血清 预后
文献标志码:
A
摘要:
【摘要】 目的 血清miRNA可作为肿瘤诊断、疗效及预后判断的潜在标记物。本研究旨在探索转移相关miRNA(miR- 18b)在经射频消融术(RFA)治疗的AFP阴性(≤ 20 ng/ml)肝癌患者血清中的表达及其临床意义。方法 自2007年1月—2011年1月,接受RFA治疗的AFP阴性肝癌患者131例纳入本研究,收集RFA术前血清标本并选择43例正常人血清作对照组。采用实时定量PCR方法检测血清中miR- 18b的表达水平,并分析其表达水平高低与临床病理、术后复发、总生存率及无复发生存率之间的关系。结果 在肝癌患者血清中miR- 18b表达水平显著高于正常人(2.93 ± 1.33 对1.08 ± 0.45,P < 0.01),且高表达的miR- 18b与肝硬化(P = 0.035)、肿瘤直径(P < 0.01)及肿瘤分化程度(P = 0.020)密切相关。随访期间,79例(60.3%)患者出现复发,复发患者血清中miR- 18b水平较无复发患者显著升高(3.26 ± 1.28对 2.42 ± 0.86,P < 0.01)。与miR- 18b低表达的患者相比,高表达患者RFA术后复发的发生率显著较高(72.3%对48.5%,P = 0.005),尤其是肝内远处转移率。Kaplan- Meier生存分析显示血清miR- 18b高表达的患者总生存率及无复发生存率均显著短于低表达者。结论 血清miR- 18b在AFP阴性肝癌患者血清中显著升高,或可作为监测RFA术后复发及预后的理想标记物。

参考文献/References:

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备注/Memo

备注/Memo:
(收稿日期:2013-11-06)
更新日期/Last Update: