[1]彭晶晶,谭 勇,谭 艳,等. 125I粒子植入治疗结肠直肠癌肝转移[J].介入放射学杂志,2012,(09):773-776.
 PENG Jing- jing,TAN Yong,TAN- Yan,et al. Interstitial implantation of 125I seeds for the treatment of colorectal liver metastases[J].journal interventional radiology,2012,(09):773-776.
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2012年09期
页码:
773-776
栏目:
临床研究
出版日期:
2012-09-30

文章信息/Info

Title:
 Interstitial implantation of 125I seeds for the treatment of colorectal liver metastases
作者:
 彭晶晶 谭 勇 谭 艳 魏 东 付增强 张 涛
Author(s):
 PENG Jing- jing TAN Yong TAN- Yan WEI Dong FU Zeng- qiang ZHANG Tao.
 Department of Oncology, General Hospital of Chengdu Military Region, Chengdu 610000, China
关键词:
 【关键词】 结直肠癌 肝转移 125I粒子 组织间内放疗
文献标志码:
A
摘要:
 【摘要】 目的 探讨放射性125I粒子植入治疗结肠直肠癌肝转移(CRLM)的疗效及安全性。方法 为24例化疗失败或不能耐受化疗的CRLM患者共计65个肝转病灶行CT引导下植入125I粒子,粒子的放射性活度介于0.5 ~ 0.7 mCi,每例患者接种的粒子数为18 ~ 109枚,最小边缘剂量为110 ~ 160 Gy。植入后进行质量验证。结果 在6个月的随访中,肿瘤的最长径基线和从术前(7.21 ± 3.28) cm降到术后3个月时的(4.47 ± 3.34)和6个月时的(3.94 ± 2.05) cm,差异有统计学意义(P < 0.05)。CEA由术前的(293 ± 89) ng/ml降至术后3、6个月的(198 ± 103)ng/ml、(155 ± 61) ng/ml,差异有统计学意义(P < 0.05)。未出现与治疗相关的死亡。1、2年生存率分别为87.5%和75.0%。结论 CT引导下125I粒子植入治疗CRLM微创、安全,近期疗效确切,远期疗效有待观察。

参考文献/References:

 [1] Chun YS, Laurent A, Maru D, et al. Management of chemotherapy?蛳 associated hepatotoxicity in colorectal liver meta?蛳stases[J]. Lancet Oncol, 2009, 10: 278 ?蛳 286.
[2] Chiappa A, Makuuchi M, Lygidakis NJ, et al. The management of colorectal liver metastases: Expanding the role of hepatic resection in the age of multimodal therapy[J]. Crit Rev Oncol Hematol, 2009, 72: 65 ?蛳 75.
[3] Hebbar M, Pruvot FR, Romano O, et al. Integration of neoadjuvant and adjuvant chemotherapy in patients with resectable liver metastases from colorectal Cancer[J]. Cancer Treat Rev, 2009, 35: 668 ?蛳 675.
[4] Smith MD, Mccall JL. Systematic review of tumour number and outcome after radical treatment of colorectal liver metastases[J]. Br J Surg, 2009, 96: 1101 ?蛳 1113.
[5] Wachsberger P, Burd R, Ryan A, et al. Combination of vandetanib radiotherapy,and irinotecan in the LoVo human colorectal cancer xenograft model[J]. Int J Radiat Oncol Biol Phys, 2009, 75: 854 ?蛳 861.
[6] Pwint TP, Midgley R, Kerr DJ. Regional hepatic chemotherapies in the treatment of colorectal Cancer metastases to the liver[J]. Semin Oncol, 2010, 37: 149 ?蛳 159.
[7] 林俊清, 杨维竹, 江 娜, 等. CT引导下 ~ (125)I放射性粒子植入治疗原发性肝细胞癌伴门静脉癌栓[J]. 中国介入影像与治疗学, 2011, 8: 299 ?蛳 302.
[8] Kono Y, Kubota K, Mitsumoto T, et al. Scintigraphic detection of 125I seeds after permanent brachytherapy for prostate Cancer[J]. J Nucl Med, 2008, 49: 541 ?蛳 545.
[9] Guo JH, Teng GJ, Zhu GY, et al. Self?蛳 expandable esophageal stent loaded with 125I seeds: initial experience in patients with advanced esophageal Cancer[J]. Radiology, 2008, 247: 574 ?蛳 581.
[10] Siebert FA, Kohr P, Kovács G. Comparison of CT?蛳 and radiograph?蛳 based post?蛳 implant dosimetry for transperineal 125I prostate brachytherapy using single seeds and a commercial treatment?蛳 planning software[J]. Strahlenther Onkol, 2006, 182: 96 ?蛳 101.

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备注/Memo

备注/Memo:
 (收稿日期:2012-02-05)
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