[1]翟義胲,林 雪,蒲圆金,等.基于机器学习的肝动脉化疗栓塞术后栓塞综合征预测模型构建和比较[J].介入放射学杂志,2023,32(09):886-890.
　ZHAI Yihai,LIN Xue,PU Yuanjin,et al.Construction of the model based on machine learning algorithm technique used for predicting post-embolization syndrome after hepatic artery chemoembolization[J].journal interventional radiology,2023,32(09):886-890.
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基于机器学习的肝动脉化疗栓塞术后栓塞综合征预测模型构建和比较()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
32
期数:
2023年09
页码:
886-890
栏目:
临床研究
出版日期:
2023-09-27

文章信息/Info

Title:
Construction of the model based on machine learning algorithm technique used for predicting post-embolization syndrome after hepatic artery chemoembolization
作者:
翟義胲;  林 雪;  蒲圆金;  韦巧玲;  庞永慧
Author(s):
ZHAI Yihai;  LIN Xue;  PU Yuanjin;  WEI Qiaoling;  PANG Yonghui.
Department of Interventional Treatment， Affiliated Tumor Hospital， Guangxi Medical University， Nanning， Guangxi Zhuang Autonomous Region 530021， China
关键词:
【关键词】 原发性肝癌;  肝动脉化疗栓塞术;  机器学习;  随机森林;  栓塞综合征
文献标志码:
A
摘要:
【摘要】 目的 探讨不同的机器学习技术在预测经肝动脉化疗栓塞术后发生栓塞综合征的效能。方法 收集2020年1月至2021年12月在广西医科大学附属肿瘤医院接受肝动脉化疗栓塞术的453例患者临床资料。分别采取逻辑回归、支持向量机、随机森林、梯度提升决策树、极端梯度森林和Lightgbm等6种机器学习技术，构建术后发生栓塞综合征的预测模型。采取五折交叉验证的方式计算不同机器学习算法的准确率、精确率、召回率、F1值和曲线下面积（AUC）。结果 经动脉化疗栓塞术后栓塞综合征的发生率为62.47%，基于随机森林算法的平均评估指标值为0.768，优于其他机器学习模型。结论 基于随机森林方法建立经动脉化疗栓塞术后栓塞综合征发生的预测模型效能最佳。

参考文献/References:

［1］ Xia C， Dong X， Li H， et al. Cancer statistics in China and United States， 2022： profiles，trends，and determinants［J］. Chin Med J（Engl）， 2022， 135： 584- 590.
［2］ 安天志，高 嵩，靳 勇，等． 中国肝细胞癌经动脉化疗栓塞治疗（TACE）临床实践指南［J］． 介入放射学杂志， 2018， 27：1117- 1126．
［3］ Blackburn H， West S. Management of postembolization syndrome following hepatic transarterial chemoembolization for primary or metastatic liver cancer［J］. Cancer Nurs， 2016， 39： E1- E18.
［4］ 尹西西，王 婷，陈敏英，等． 原发性肝癌经皮肝动脉化疗栓塞术后患者栓塞后综合征发生现状及影响因素研究［J］． 护士进修杂志， 2022， 37：749- 753．
［5］ He JJ，Yin XX，Wang T，et al. Factors influencing postembolization syndrome in patients with hepatocellular carcinoma undergoing first transcatheter arterial chemoembolization［J］. J Cancer Res Ther， 2021， 17： 777- 783.
［6］ Guo T， Fang Z， Yang G， et al. Machine learning models for predicting in- hospital mortality in acute aortic dissection patients［J］. Front Cardiovasc Med， 2021， 8：727773.
［7］ Smiti A.When machine learning meets medical world： current status and future challenges［J］. Computer Science Review， 2020， 37：100280.
［8］ Hung YW，Lee IC，Chi CT，et al. Redefining tumor burden in patients with intermediate- stage hepatocellular carcinoma： the seven- eleven criteria［J］. Liver Cancer， 2021， 10： 629- 640.
［9］ Lundberg SM， Lee SI. A unified approach to interpreting model predictions［C］. Advances in neural information processing systems， 2017：4765- 4774.
［10］ Mao B， Ma JD， Duan SB， et al. Correction to： preoperative classification of primary and metastatic liver cancer via machine learning- based ultrasound radiomics［J］. Eur Radiol， 2021， 31： 6407.
［11］ Wang Y，Ji C，Wang Y，et al. Predicting postoperative liver cancer death outcomes with machine learning［J］. Curr Med Res Opin，2021， 37：629- 634.
［12］ 中国医师协会中西医结合分会肿瘤专业委员会，河南省康复医学会消化康复分会，河南省中西医结合学会肝病分会. 原发性肝癌经肝动脉化疗栓塞术后中西医结合康复专家共识［J］．临床肝胆病杂志， 2021， 37：1545- 1549．
［13］ Mason MC，Massarweh NN，Salami A，et al. Post- embolization syndrome as an early predictor of overall survival after transarterial chemoembolization for hepatocellular carcinoma［J］. HPB（Oxford）， 2015， 17： 1137- 1144.
［14］ 罗 君，邵国良，郑家平，等． 原发性肝癌肝动脉化疗栓塞术后腹痛的发生规律及影响因素［J］． 介入放射学杂志， 2017， 26：613- 617．
［15］ Wei G，Yang J. Advances in the treatment of hepatocellular carcinoma using drug- eluting beads［J］. J Interv Med， 2020， 3： 122- 127.
［16］ Pachev A，Raynaud L，Paulatto L，et al. Correction to： predictive factors of severe abdominal pain during and after transarterial chemoembolization for hepatocellular carcinoma［J］. Eur Radiol， 2021， 31： 4405.

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[2]高 嵩,朱旭,杨仁杰,等. ＴＡＣＥ联合奥沙利铂、氟尿嘧啶、亚叶酸钙肝动脉化疗治疗中晚期原发性肝癌[J].介入放射学杂志,2012,(05):377.
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　SHI Chang-gao,LV Wei-fu,LU Dong,et al.The treatment of liver abscess occurred after transcatheter arterial chemoembolization report of five cases[J].journal interventional radiology,2011,(09):273.
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[5]张晓前,郭 鹏,党之俊,等.金龙胶囊联合介入疗法治疗原发性肝癌临床观察[J].介入放射学杂志,2012,(03):249.
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[8]刘 昕,吕维富,鲁 东,等. 动脉介入栓塞治疗肝癌破裂出血[J].介入放射学杂志,2012,(07):586.
　LIU Xin,LV Wei- fu,LU Dong,et al. Interventional treatment of hepatic bleeding due to spontaneous rupture of hepatocellular carcinoma[J].journal interventional radiology,2012,(09):586.
[9]张志良,杨学东,温阿明,等. 经动脉化疗栓塞联合伽玛刀治疗原发性肝癌的疗效评价[J].介入放射学杂志,2012,(07):596.
　ZHANG Zhi- liang,YANG Xue- dong,WEN A-ming,et al. Evaluation of TACE combined with gamma?蛳 knife radiotherapy for primary hepatocellular carcinoma[J].journal interventional radiology,2012,(09):596.
[10]赵许亚,周 石.TACE联合经皮瘤内注射碘油吡柔比星乳剂治疗中晚期肝癌疗效分析[J].介入放射学杂志,2012,(08):675.
　ZHAO Xu- ya,ZHOU Shi.. Transcatheter artery chemoembolization combined with percutaneous intratumoral injection of Lipiodol emulsion of pirarubicin for advanced hepatocellular carcinomas： an analysis of clinical efficacy[J].journal interventional radiology,2012,(09):675.
[11]冯 超,赵剑波,陈 勇,等.原发性肝癌切除术后预防性经肝动脉介入治疗：肝动脉化疗栓塞术和化疗灌注术比较[J].介入放射学杂志,2014,(08):679.
　FENG Chao,ZHAO Jian bo,CHEN Yong,et al.The preventive transhepatic interventional therapy for primary liver cancer after surgical resection： comparison study between TACE and TAI[J].journal interventional radiology,2014,(09):679.
[12]吴正阳,朱 明,周朋利,等.肝癌TACE术后破裂并发肝脓肿及肺动脉碘化油栓塞1例[J].介入放射学杂志,2016,(11):988.
　WU Zheng- yang,ZHU Ming,ZHOU Peng- li,et al.Rupture of hepatic tumor complicated by liver abscess and pulmonary lipiodol embolism after TACE： report of one case[J].journal interventional radiology,2016,(09):988.
[13]宿敬存,赵 卫,胡继红,等.TACE联合RFA及自体细胞因子诱导的杀伤细胞肝动脉灌注治疗原发性肝癌的临床研究[J].介入放射学杂志,2017,(01):24.
　SU Jing- cun,ZHAO Wei,HU Ji- hong,et al.TACE combined with RFA and hepatic artery infusion of autologous cytokine- induced killer cells for the treatment of hepatocellular carcinoma： a clinical study [J].journal interventional radiology,2017,(09):24.
[14]许 飞,李忱瑞,孙 伟,等.原发性肝癌TACE术中雷替曲塞的临床应用 [J].介入放射学杂志,2017,(05):418.
　XU Fei,LI Chenrui,SUN Wei,et al.The clinical application of raltitrexed in TACE for primary hepatocellular carcinoma[J].journal interventional radiology,2017,(09):418.
[15]刘 金,曹 刚,张根山,等.国产CalliSpheres载药微球治疗原发性肝癌12例 [J].介入放射学杂志,2017,(11):993.
　LIU Jin,CAO Gang,ZHANG Genshan,et al.Interventional chemoembolization with drug- eluting microspheres of domestic CalliSpheres for the treatment of primary hepatocellular carcinomas： preliminary results in 12 patients[J].journal interventional radiology,2017,(09):993.
[16]陈旭姣,丁长伟,畅智慧,等.原发性肝癌患者肝动脉化疗栓塞术治疗前、后血浆D- 二聚体变化的临床意义 [J].介入放射学杂志,2017,(12):1128.
　CHEN Xujiao,DING Changwei,CHANG Zhihui,et al.Clinical significance of the changes in plasma D- dimer levels in HCC patients after receiving TACE[J].journal interventional radiology,2017,(09):1128.
[17]王亚玲,王玉芹,张小曼,等.穴位按摩联合音乐疗法对肝癌介入术后患者疼痛的影响[J].介入放射学杂志,2018,27(12):1202.
　WANG Yaling,WANG Yuqin,ZHANG Xiaoman,et al.The effect of acupressure massage combined with music therapy on pain degree in patients with liver cancer after receiving interventional treatment[J].journal interventional radiology,2018,27(09):1202.
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　YANG Liang,GU Yuming,LU Jiao,et al.Contrast- enhanced ultrasonography versus contrast- enhanced MRI in the evaluation of therapeutic effect of TACE for HCC： comparison of application value[J].journal interventional radiology,2019,28(09):682.
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　CHEN Li,YU Risheng,LAI Linqiang,et al.The clinical value of myeloid- derived suppressor cell monitoring in predicting the prognosis of advanced hepatocellular carcinoma after TACE [J].journal interventional radiology,2019,28(09):742.
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　ZHU Mengchao,ZHANG Qingqiao,XU Hao,et al.Liver abscess formation caused by CalliSpheres beads treatment for primary liver cancer： analysis of 4 patients[J].journal interventional radiology,2020,29(09):939.

备注/Memo

备注/Memo:
（收稿日期：2022- 07- 06）
（本文编辑：新 宇）
更新日期/Last Update: 2023-09-26