[1]史　浩,卢维龙,石朝海,等.导管搅拌碎栓联合局部高压溶栓治疗急性肺栓塞效果[J].介入放射学杂志,2023,32(01):22-25.
　SHI Hao,LU Weilong,SHI Chaohai,et al.Catheter-stirring thrombectomy combined with local high-pressure thrombolytic therapy for acute pulmonary embolism[J].journal interventional radiology,2023,32(01):22-25.
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导管搅拌碎栓联合局部高压溶栓治疗急性肺栓塞效果()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
32
期数:
2023年01
页码:
22-25
栏目:
血管介入
出版日期:
2023-02-13

文章信息/Info

Title:
Catheter-stirring thrombectomy combined with local high-pressure thrombolytic therapy for acute pulmonary embolism
作者:
史　浩; 　卢维龙; 　石朝海; 　温世奇; 　牛启兵; 　孙万里; 　王力田; 　 朱占弟; 　陈　泉
Author(s):
SHI Hao; LU Weilong; SHI Chaohai; WEN Shiqi; NIU Qibing; SUN Wanli; WANG Litian; ZHU Zhandi; CHEN Quan.
Department of Vascular Surgery, Gansu Provincial People’s Hospital, Lanzhou, Gansu Province 730000, China
关键词:
【关键词】 急性肺栓塞; 溶栓术; 重组人尿激酶原; 介入治疗
文献标志码:
A
摘要:
【摘要】　目的　探讨导管搅拌碎栓联合局部高压溶栓治疗急性肺栓塞（APE）的安全性和有效性。 方法　回顾性分析2019年1月至2020年12月在甘肃省人民医院接受导管搅拌碎栓联合局部高压注射重组人尿激酶原（rhPro-UK）溶栓治疗的23例APE患者临床资料。观察术前和术后48 h患者临床指标变化、并发症发生情况。随访6个月，观察术后1、3、6个月肺动脉压（PAP）变化。结果　23例患者治疗均获临床成功。术前和术后48 h临床指标比较，差异有统计学意义（P＜0.01）；无死亡、胸腔积血、心包积液、颅内出血等主要不良事件发生。术后1、3、6个月PAP变化比较，差异无统计学意义（均P＞0.05）。结论　导管搅拌碎栓联合局部高压溶栓治疗APE安全有效，近期效果满意。

参考文献/References:

［1］　Schulman S, Ageno W, Konstantinides S. Venous thromboembolism: past, present and future［J］. Thromb Haemost, 2017, 117: 1219-1229.
［2］　Morrone D, Morrone V. Acute pulmonary embolism: focus on the clinical picture［J］. Korean Circ J, 2018, 48: 365-381.
［3］　中华医学会心血管病学分会肺血管病学组.急性肺栓塞诊断与治疗中国专家共识（2015） ［J］. 中华心血管病杂志, 2016, 44: 197-211.
［4］　Wendelboe AM, Raskob GE. Global burden of thrombosis: epidemiologic aspects［J］. Circ Res, 2016, 118: 1340-1347.
［5］　Keller K, Hobohm L, Ebner M, et al. Trends in thrombolytic treatment and outcomes of acute pulmonary embolism in Germany［J］. Eur Heart J, 2020, 41: 522-529.
［6］　Fang MC, Fan D, Sung SH, et al. Treatment and outcomes of acute pulmonary embolism and deep venous thrombosis: the CVRN VTE study［J］. Am J Med, 2019, 132: 1450-1457.
［7］　Dumantepe M, Uyar I, Teymen B, et al. Improvements in pulmonary artery pressure and right ventricular function after ultrasound-accelerated catheter-directed thrombolysis for the treatment of pulmonary embolism［J］. J Card Surg, 2014, 29: 455-463.
［8］ Ceresetto JM. Venous thromboembolism in Latin America: a review and guide to diagnosis and treatment for primary care［J］. Clinics （Sao Paulo）, 2016, 71: 36-46.
［9］　陈丹丹，吴玥婷，陈保林，等. 急性肺栓塞误诊为急性冠状动脉综合征51例分析［J］.介入放射学杂志，2019，28：1029-1031.
［10］Villalba L, Nguyen T, Feitosa RL Jr, et al. Single-session catheter-directed lysis using adjunctive power-pulse spray with angiojet for the treatment of acute massive and submassive pulmonary embolism［J］. J Vasc Surg, 2019, 70: 1920-1926.
［11］ Tebbe U, Graf A, Kamke W, et al. Hemodynamic effects of double bolus reteplase versus alteplase infusion in massive pulmonary embolism［J］. Am Heart J, 1999, 138: 39-44.
［12］ Konstantinides S, Tiede N, Geibel A, et al. Comparison of alteplase versus heparin for resolution of major pulmonary embolism［J］. Am J Cardiol, 1998, 82: 966-970.
［13］ Becattini C, Agnelli G, Salvi A, et al. Bolus tenecteplase for right ventricle dysfunction in hemodynamically stable patients with pulmonary embolism［J］. Thromb Res, 2010, 125: e82-e86.
［14］ Putnam A, Carey K, Marginean A, et al. Safety and efficacy of catheter-directed therapy versus anticoagulation alone in a higher-risk acute pulmonary embolism population［J］. J Thromb Thrombolysis, 2021, 52: 1151-1159.
［15］ Park B, Messina L, Dargon P, et al. Recent trends in clinical outcomes and resource utilization for pulmonary embolism in the United States: findings from the nationwide inpatient sample［J］. Chest, 2009, 136: 983-990.
［16］ Carvalho EM, Macedo FI, Panos AL, et al. Pulmonary embolectomy: recommendation for early surgical intervention［J］. J Card Surg, 2010, 25: 261-266.
［17］ 王庆庆，施海彬，周卫忠，等. 单纯经皮机械祛栓治疗急性大面积肺栓塞的临床应用［J］.介入放射学杂志，2010，19：291-295．
［18］ Jacobs B, Henke PK. Evidence-based therapies for pharmacologic prevention and treatment of acute deep vein thrombosis and pulmonary embolism［J］. Surg Clin North Am, 2018, 98: 239-253.
［19］ 魏立春，侯培勇. 中、高危急性肺动脉栓塞的腔内治疗进展［J］.血管与腔内血管外科杂志，2019，5：169-173．
［20］ Piran S, Schulman S. Management of venous thromboembolism: an update［J］. Thromb J, 2016, 14 （Suppl 1）: 23.
［21］ Leacche M, Unic D, Goldhaber SZ, et al. Modern surgical treatment of massive pulmonary embolism: results in 47 consecutive patients after rapid diagnosis and aggressive surgical approach［J］. J Thorac Cardiovasc Surg, 2005, 129: 1018-1023.
［22］ Arzamendi D, Bilodeau L, Ibrahim R, et al. Role of rheolytic thrombectomy in massive pulmonary embolism with contraindication to systemic thrombolytic therapy［J］. EuroIntervention, 2010, 5: 716-721.
［23］ 宋锦文，王志宏，王新林，等. 导管碎栓联合局部灌注瑞替普酶溶栓治疗高危肺动脉栓塞［J］.介入放射学杂志，2014，23：870-873．

相似文献/References:

[1]陈丹丹,吴玥婷,陈保林,等.急性肺栓塞误诊为急性冠状动脉综合征51例分析 [J].介入放射学杂志,2019,28(11):1029.
　CHEN Dandan,WU Yueting,CHEN Baolin,et al.Acute pulmonary embolism misdiagnosed as acute coronary syndrome: analysis of 51 cases[J].journal interventional radiology,2019,28(01):1029.

备注/Memo

备注/Memo:
（收稿日期：2021-12-17）
（本文编辑：边　佶）　　
更新日期/Last Update: 2023-02-13