[1]潘晓虎,朱发勇,邱　凯,等.血浆D-二聚体水平对急性缺血性脑卒中颅内动脉粥样硬化性大血管闭塞的预测价值[J].介入放射学杂志,2023,32(01):9-13.
　PAN Xiaohu,ZHU Fayong,QIU Kai,et al.The predictive value of plasma D-dimer level for acute intracranial atherosclerotic large vessel occlusion in acute ischemic stroke[J].journal interventional radiology,2023,32(01):9-13.
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血浆D-二聚体水平对急性缺血性脑卒中颅内动脉粥样硬化性大血管闭塞的预测价值()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
32
期数:
2023年01
页码:
9-13
栏目:
神经介入
出版日期:
2023-02-13

文章信息/Info

Title:
The predictive value of plasma D-dimer level for acute intracranial atherosclerotic large vessel occlusion in acute ischemic stroke
作者:
潘晓虎; 　朱发勇; 　邱　凯; 　施海彬; 　刘　圣
Author(s):
PAN Xiaohu;  ZHU Fayong;  QIU Kai;  SHI Haibin;  LIU Sheng.
Department of Neurology, Xuyi County People’s Hospital, Huai’an, Jiangsu Province 211700, China
关键词:
【关键词】 D-二聚体; 急性缺血性脑卒中; 大血管闭塞; 动脉粥样硬化; 脑卒中分型; 机械取栓
文献标志码:
A
摘要:
【摘要】　目的　评价血浆D-二聚体水平对接受脑动脉再通治疗的急性缺血性脑卒中（AIS）患者血管闭塞类型的预测价值。方法　回顾性分析2019年1月至2020年8月于南京医科大学第一附属医院接受脑动脉再通治疗的AIS患者临床资料。根据术中血管造影结果，将患者分为急性颅内动脉粥样硬化性狭窄（ICAS）所致大血管闭塞（LVO）（ICAS-LVO组）和非ICAS所致LVO（非ICAS-LVO组）。所有患者均在到达急诊时接受血样采集, 检测D-二聚体（D-D）水平。采用单因素和多因素logistic回归分析确定ICAS-LVO相关预测因子，与D-D相关性；受试者工作特征曲线（ROC）评价D-D水平预测ICAS-LVO的价值。结果　共纳入273例患者。其中79例（28.9%）患者诊断为ICAS-LVO。与非ICAS-LVO组患者相比，ICAS-LVO组患者更年轻，男性比例更高，有吸烟史者更多，伴心房颤动更少，美国国立卫生研究院卒中量表（NIHSS）评分基线值更低（均P＜0.05）。ICAS-LVO组患者血浆D-D水平显著低于非ICAS-LVO组患者（0.39 mg/L比1.20 mg/L，P＜0.01）。多因素logistic回归分析显示，较低D-D与ICAS-LVO呈显著正相关（OR=0.30，95%CI=0.18～0.47，P＜0.01）。基于ROC，血浆D-D预测ICAS-LVO的最佳临界值为0.84 mg/L，灵敏度为84.8%，特异度为67.5%，阴性预测值为91.6%，曲线下面积（AUC）为0.830。结论　基线低D-D水平是ICAS-LVO的独立预测因子，有助于神经介入医师预先制定血管再通治疗策略。

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备注/Memo

备注/Memo:
（收稿日期：2022-05-28）
（本文编辑：边　佶）
更新日期/Last Update: 2023-02-13