[1]赵宛玉,杜敢琴,段佩养,等.颈动脉支架植入术对颈动脉狭窄患者认知功能影响的meta分析 [J].介入放射学杂志,2020,29(02):129-135.
　ZHAO Wanyu,Du Ganqin,DUAN Peiyang,et al.The effect of carotid artery stenting on the cognitive function of patients with carotid artery stenosis: a meta-analysis?[J].journal interventional radiology,2020,29(02):129-135.
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颈动脉支架植入术对颈动脉狭窄患者认知功能影响的meta分析
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
29
期数:
2020年02
页码:
129-135
栏目:
神经介入
出版日期:
2020-03-14

文章信息/Info

Title:
The effect of carotid artery stenting on the cognitive function of patients with carotid artery stenosis: a meta-analysis?
作者:
赵宛玉; 杜敢琴; 段佩养; 陈胜江
Author(s):
ZHAO Wanyu;  Du Ganqin;  DUAN Peiyang;  CHEN Shengjiang.
The Clinical Medical College of Henan University of Science and Technology, Department of Neurology, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan Province 471003, China
关键词:
【关键词】　颈动脉狭窄; 颈动脉支架植入术; 认知功能; meta分析
文献标志码:
A
摘要:
【摘要】　目的?评价颈动脉支架植入术（CAS）对颈动脉狭窄患者认知功能的干预作用。方法?计算机检索Medline、EMbase、Pubmed、CNKI、万方和维普等数据库，选取建库至2018年12月30日收录的CAS对颈动脉狭窄患者认知功能影响的随机对照试验（RCT）和队列研究文献，CAS组为试验组，药物治疗组为对照组。对比两组简易智能精神状态检查（MMSE）量表、蒙特利尔认知评估（MOCA）量表、数字广度（DS）测试和Barthel指数（BI）量表评分评估结果。2名研究员按照纳入和排除标准独立筛选文献、提取资料、评价文献质量后，采用RevMan 5.3软件作meta分析。结果?共纳入2篇RCT、16篇队列研究文献，1 756例患者。Meta分析结果显示，CAS组与药物治疗组相比，术后1个月MMSE量表评分差异无统计学意义（MD=1.01，95% CI=－0.24～2.27，P=0.11），MOCA量表评分显著升高（MD=1.88，95%CI=0.83～2.92，P=0.000 4）；术后3个月MMSE评分、MOCA评分均显著升高（MD=2.06，95%CI=0.62～3.50，P=0.005；MD=2.42，95%CI：0.9～3.95，P=0.002）；术后6个月MMSE评分、MOCA评分均显著升高（MD=2.79，95%CI=1.47～4.11，P＜0.000 1；MD=3.18，95%CI=1.73～4.63，P＜0.000 1），DS测试评分、BI量表评分差异均无统计学意义（MD=－1.37，95%CI=－0.1～2.83，P=0.07；MD=－2.53，95%CI=
－7.62～2.56，P=0.33）；术后1年，MOCA评分差异无统计学意义（MD=0.37，95%CI=－4.58～5.33，P=0.88）。结论?CAS可改善颈动脉狭窄患者术后3、6个月认知功能，对远期认知功能影响尚需大规模、多中心、高质量RCT研究进一步验证。

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备注/Memo

备注/Memo:
（收稿日期：2018-11-26）
（本文编辑：边?佶）
更新日期/Last Update: 2020-03-13