[1]钟继明,黄学成,张景昌,等.冠状动脉雷帕霉素涂层支架植入术后支架内再狭窄临床预测因素探讨 [J].介入放射学杂志,2017,(10):874-877.
 ZHONG Jiming,HUANG Xuecheng,ZHANG Jingchang,et al.Investigation of the clinical predictors of in- stent restenosis after rapamycin- eluting coronary stent implantation[J].journal interventional radiology,2017,(10):874-877.
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2017年10期
页码:
874-877
栏目:
心脏介入
出版日期:
2017-10-25

文章信息/Info

Title:
Investigation of the clinical predictors of in- stent restenosis after rapamycin- eluting coronary stent implantation
作者:
钟继明 黄学成 张景昌 曾煜周
Author(s):
ZHONG Jiming HUANG Xuecheng ZHANG Jingchang ZENG Yuzhou
Department of Cardiology, Third Affiliated Hospital of Guangxi Medical University, Nanning, the Guangxi Zhuang Autonomous Region 530031, China
关键词:
【关键词】 氧化型低密度脂蛋白 同型半胱氨酸 冠状动脉性心脏病 药物洗脱支架 支架内再狭窄
文献标志码:
A
摘要:
【摘要】 目的 分析氧化型低密度脂蛋白(ox- LDL)、同型半胱氨酸(Hcy)与冠状动脉支架内再狭窄(ISR)的关系,探讨雷帕霉素涂层支架植入后ISR临床预测因素。方法 入选400例冠状动脉雷帕霉素涂层支架植入患者,根据冠状动脉复查造影结果分为ISR组和无ISR组。术前及复查造影时检测血浆ox- LDL、Hcy水平。采用多元Logistic回归分析评价ISR相关临床参数、血管造影特征及手术相关因素。结果 ISR组48例,无ISR组352例,临床ISR发生率为13.6%。与无ISR组比较,ISR组患者支架植入术前、冠状动脉复查造影时血浆ox- LDL、Hcy水平明显升高,差异均有统计学意义(P<0.05)。多元Logistic回归分析结果显示,伴高血压病、伴糖尿病、Hcy、ox- LDL、服用他汀类药物、吸烟、冠状动脉开口病变、冠状动脉分叉病变、慢性完全闭塞病变、参考血管直径、术前血管狭窄程度、植入支架直径、植入支架长度为ISR独立相关因素。结论 冠状动脉雷帕霉素涂层支架植入后ISR并不少见。伴高血压、伴糖尿病、Hcy、ox- LDL、吸烟、冠状动脉开口病变、冠状动脉分叉病变、慢性完全闭塞病变、术前血管狭窄程度、参考血管直径、植入支架直径、植入支架长度为ISR独立相关因素。长期规律服用他汀类药物可降低ISR风险。

参考文献/References:

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备注/Memo

备注/Memo:
(收稿日期:2017-04-12)
(本文编辑:边 佶)
更新日期/Last Update: 2017-10-15