[1]付 元,纪建松,涂建飞,等.TACE联合RFA及索拉菲尼在肝癌外科术后复发治疗中的临床应用[J].介入放射学杂志,2015,(12):1067-1071.
 FU Yuan,JI Jian- song,TU Jian- fei,et al.The clinical application of TACE combined with RFA and sorafenib in treating recurrent hepatocellular carcinoma after surgery[J].journal interventional radiology,2015,(12):1067-1071.
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TACE联合RFA及索拉菲尼在肝癌外科术后复发治疗中的临床应用 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2015年12期
页码:
1067-1071
栏目:
肿瘤介入
出版日期:
2015-12-25

文章信息/Info

Title:
The clinical application of TACE combined with RFA and sorafenib in treating recurrent hepatocellular carcinoma after surgery
作者:
付 元 纪建松 涂建飞 宋晶晶
Author(s):
FU Yuan JI Jian- song TU Jian- fei SONG Jing- jing. Department of Interventional Radiology Lishui
Hospital of Zhejiang University, Lishui Municipal Central Hospital, Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang Province 323000, China
关键词:
 【关键词】 化疗栓塞术 射频消融 索拉菲尼 肝细胞肝癌 外科切除
文献标志码:
A
摘要:
【摘要】 目的 观察经导管肝动脉化疗栓塞术(TACE)联合射频消融(RFA)及索拉菲尼对肝癌切除术后复发患者治疗的临床价值。方法 收集40例2009年12月至2014 年5月肝细胞肝癌术后复发患者,其中20例采用TACE联合RFA和口服索拉菲尼(治疗组);20例行TACE联合RFA(对照组)。TACE联合RFA即TACE术后7 d~10 d天行RFA治疗,以下简称TACE联合RFA术。索拉菲尼于TACE术后4 d开始口服。400 mg 2次/d,若出现耐药则停药,每位患者行TACE联合RFA术不少于2次。结果 治疗组中位生存时间为 31.0个月,对照组中位生存时间为24.8个月,组间比较差异有统计学意义(P<0.05)。治疗组1、2、3年生存率分别为85%、70%、50%,对照组分别为80%、55%、30%。1、2、3年生存率组间比较差异均无统计学意义(P>0.05)。治疗组无进展生存期为6.8个月;对照组无进展生存期为5.7个月,差异有统计学意义(P<0.05)。结论 TACE联合RFA和口服索拉菲尼能延长肝癌切除术后复发患者的总生存期及无进展生存期。

参考文献/References:

[1] Venook AP, Papandreou C, Furuse J, et al. The incidence and epidemiology of hepatocellular carcinoma: a global and regional perspective[J]. Oncologist, 2010, 15: 5- 13.
[2] Tu J, Ji J, Wu F, et al. Effectiveness of combined 131I- chTNT and radiofrequency ablation therapy in treating advanced hepatocellular carcinoma[J]. Cell Biochem Biophys, 2015, 71: 777- 784.
[3] 杨甲梅. 重视复发性原发性肝癌的外科治疗[J]. 临床外科杂志, 2005, 13: 129- 130.
[4] 孙 燕, 赵 平. 临床肿瘤学进展[M]. 北京: 中国协和医科大学出版社, 2005: 656- 668.
[5] 葛乃建, 杨业发, 申淑群, 等. 经皮穿刺射频消融治疗门静脉癌栓15例[J]. 介入放射学杂志, 2014, 23: 883- 886.
[6] Kobayshi M, Ikeda K, Kawamura Y, et al. Randomized controlled trial for the efficacy of hepatic arterial occlusion during radiofrequency ablation for small hepatocellular carcinoma—direct ablative effects and a long- term outcome[J]. Liver Int,2007, 27: 353- 359.
[7] Tu JF, Xu HH, Ying XH, et al. Comparative study of several microinvasive treatments for large hepatocellular carcinoma[J]. Eur Rev Med Pharmacol Sci, 2015, 19: 45- 53.
[8] Peng ZW, Zhang YJ, Chen MS, et al. Risk factors of survival after percutaneous radiofrequency ablation of hepatocellular carcinoma[J]. Surg Oncol, 2008, 17: 23- 31.
[9] 杜锡林, 王义清, 马庆久, 等. 肝动脉栓塞对射频治疗肝癌的影响[J]. 介入放射学杂志, 2004, 13: 50- 52.
[10] Suzuki H, Mori M, Kawaguchi C, et al. Serum vascular endothelial growth factor in the course of transcatheter arterial embolization of hepatocellular carcinoma[J]. Int J Oncol, 1999, 14: 1087- 1090.
[11] Ranieri G, Gadaleta- Caldarola G, Goffredo V, et al. Sorafenib (BAY 43-9006) in hepatocellular carcinoma patients: from discovery to clinical development[J]. Curr Med Chem, 2012, 19: 938- 944.
[12] Wiedmann MW, Mossner J. Molecular targeted therapy of hepatocellular carcinoma- results of the first ciinical studies[J]. Curr Cancer Drug Targets, 2011, 11: 714- 733.
[13] Lacouture ME, Wu S, Robert C, et al. Evolving strategies for the management of hand- foot skin reaction associated with the multitar- geted kinase inhibitors sorafenib and sunitinib[J]. Oncologist, 2008, 13: 1001- 1011.
[14] 张惠洁, 郭卫东. 索拉菲尼在肿瘤治疗中的研究进展[J]. 中华临床医师杂志: 电子版, 2013, 7: 137- 139.
[15] Sasaki A, Iwashita Y, Shibata K, et al. Preoperative transcatheter arterial chemoembolization reduces long- term survival rate after hepatic resection for resectable hepatocellular carcinoma[J]. Eur J Surg Oncol, 2006, 32: 773- 779.
[16] Jenab- Wolcott J, Giantonio BJ. Bevacizumab: current indications and future development for management of solid tumors[J]. Expert Opin Biol Ther, 2009, 9: 507- 517.
[17] Dal Lago L, D’hondt V, Awada A. Selected combination therapy with sorafenib: A review of clinical data and perspectives in advanced solid tumors[J]. Oncologist, 2008, 13: 845- 858.
[18] Kelley RK, Venook AP. Sorafenib in hepatocellular carcinoma: separating the hype from the hope[J]. J Clin Oncol, 2008, 26:5845- 5848.
[19] 刘 冲. 索拉菲尼对肝癌HepG2细胞的抑制作用及其对CDK5表达水平的影响[D]. 太原: 山西医科大学, 2013.
[20] Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis[J]. Cancer Res, 2004, 64: 7099- 7109.
[21] Chang YS, Adnane J, Trail PA, et al. Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models[J]. Cancer Chemother Pharmacol, 2007, 59: 561- 574.
[22] Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma[J]. N Engl J Med, 2008, 359: 2498- 2499.
[23] Cheng AL, Kang YK, Chen Z, et al. Efficacy and safety of sorafenib in patients in the Asia- Pacific region with advanced hepatocellular carcinoma: a phase Ⅲ randomised, double- blind, placebo- controlled trial[J]. Lancet Oncol, 2009, 10: 25- 34.
[24] Goldberg SN, Hahn PF, Tanabe KK, et al. Percutaneous radiofre quency tissue ablation: does perfusion mediated tissue cooling limitcoagulation necrosis?[J]. J Vasc Interv Radiol, 1998, 9: 01- 111.
[25] Ikeda K, Seki T, Umehara H, et al. Clinicopathologic study of small hepatocellular carcinoma with microscopic satellite nodules to determine the extent of tumor ablation by local therapy[J]. Int J Oncol, 2007, 31: 485- 491.

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备注/Memo

备注/Memo:
(收稿日期:2015-06-21)
(本文编辑:俞瑞纲)
更新日期/Last Update: 2015-12-24